Berger was the mastermind behind Chelsea Lately, Keeping Up With the Kardashians and The Girls Next Door.
Prior to her arrival at E!, Berger was an executive vice president at Fox TV Studios and helped developed Road Rules at MTV.
“After nine wonderful years at E!, I have made the difficult decision to leave my post as President, Entertainment Programming,” Berger said in a statement. “My time at E! has been an amazing experience both professionally and personally, and it is hard to sum up nearly a decade of show launches, milestone moments and incredible friendships.”
No announcement has been made about Berger’s replacement.