From Lit Agent X: "Humorous novels with male protagonists are harder sells than humorous novels with female protagonists." Also, "I know it's not fun to believe, but if you meet an editor at a conference, and they express interest in your work and invite you to submit it via an agent, this doesn't mean they loved it and can't wait to read it. It means they're saying don't send this to me unless you have an agent who has prescreened this to make sure it's not terrible."

From Le Snark: "POD is not Vanity is not Self Publish", and also, "I think it's imperative for a writer to have a web site. You don't need to keep a blog, but you MUST have a site. These days not having a site is like not having a phone."

From PubRants: "If you sell the e-rights to your project it can preclude a later print rights sale since most publishers often want to buy the print and electronic rights at the same time and if the electronic rights are tied up."

And finally, this isn't really advice but it's possible you could learn something from Evil Editor's forthcoming book.