TVNewser has learned that for the first time since leaving Nightline, Ted Koppel will host a regularly-scheduled series. This Wednesday, he’ll guest host NPR’s daily news talk show, “Talk of the Nation.”

The two-hour, two-topic show will include a discussion on living with cancer with guests Elizabeth Edwards and longtime Nightline producer Leroy Sievers. Koppel will also discuss the China/US relationship, in particular the potential collision over dwindling energy supplies. Koppel’s 4-part series “The People’s Republic of Capitalism” premieres Wednesday night on Discovery.

The show is broadcast on 280 stations as well as Sirius satellite radio. Koppel, who’ll host the show live from the Newseum, is sitting in for the regular host, Neal Conan, who is on vacation.