SystImmune
Scientist/Senior Scientist, Protein Design
SystImmune, Redmond, Washington, United States, 98052
SystImmune is a leading and well‑funded clinical‑stage biopharmaceutical company located in Redmond, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug‑development platforms, focusing on bi‑specific, multi‑specific antibodies and antibody‑drug conjugates (ADCs). SystImmune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials, SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discovery and IND‑enabling stages, representing cutting‑edge biologics development. We offer an opportunity for you to learn and grow while making significant contributions to the company’s success.
SystImmune Inc. is looking for a creative and motivated
Protein Design Scientist
or
Senior Scientist
to work in our
Computational Protein Design
group. As part of the early scientific team, this individual will be involved in executing and improving the Computational Protein Design pipeline, using data‑driven approaches to augment SystImmune Inc.’s first‑in‑class multi‑specific biological programs.
The ideal candidate will have industry experience applying computational methods to design novel peptides and proteins, such as structural modeling and prediction, structure library generation, molecular docking, and multiparameter molecular property optimization. A successful candidate will be an excellent collaborator working closely with our Antibody Discovery, Protein Engineering, and Immuno‑oncology teams.
Responsibilities
Execute and improve a computational design pipeline for predicting the properties of peptides, natural ligands, de novo proteins, and antibody‑based elements via a data‑driven approach.
Drive assay validation, tech transfer, and development initiatives to maintain industry standards; contribute within the computational protein design group to operate yeast display‑based protein discovery platforms.
Design new macromolecular therapeutics using structural and sequence analysis, and employ these in silico predictions to iteratively guide the lead development process.
Analyze, interpret, document and present data to the scientific and leadership team.
Work within a collaborative, interdisciplinary team to actively contribute to executing the vision of the company.
Qualifications
PhD (or equivalent) in bioengineering, biophysics, biochemistry, molecular biology, cell biology, or a related field.
8+ years of experience using yeast libraries to generate protein binding or therapeutic antibodies.
Experience solving problems related to peptide and protein design, modeling, and sequence/structure‑function prediction, with expertise in macromolecular modeling software such as AlphaFold, RoseTTAFold, RFdiffusion, ProteinMPNN, Gromacs, MOE, Schrödinger.
Expertise in screening and ranking antibodies (ELISA, multi‑parametric flow cytometry, BLI/OCTET).
Proven contribution to therapeutic antibody development and selection is desirable; design and validate novel biologically relevant antibodies is highly desirable.
Compensation and Benefits The expected base salary range for this position is $150,000 – $250,000 annually. Actual compensation will be based on a variety of factors, including but not limited to a candidate’s qualifications, experience, and skills.
SystImmune offers a comprehensive benefits package including:
100% paid employee premiums for medical, dental, and vision
Short‑term and long‑term disability insurance
401(k) plan with a 50% company match up to 3% and a 5‑year vesting schedule
15 PTO days per year, sick leave, and 11 paid holidays
Additional benefits and perks
Equal Opportunity SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.
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SystImmune Inc. is looking for a creative and motivated
Protein Design Scientist
or
Senior Scientist
to work in our
Computational Protein Design
group. As part of the early scientific team, this individual will be involved in executing and improving the Computational Protein Design pipeline, using data‑driven approaches to augment SystImmune Inc.’s first‑in‑class multi‑specific biological programs.
The ideal candidate will have industry experience applying computational methods to design novel peptides and proteins, such as structural modeling and prediction, structure library generation, molecular docking, and multiparameter molecular property optimization. A successful candidate will be an excellent collaborator working closely with our Antibody Discovery, Protein Engineering, and Immuno‑oncology teams.
Responsibilities
Execute and improve a computational design pipeline for predicting the properties of peptides, natural ligands, de novo proteins, and antibody‑based elements via a data‑driven approach.
Drive assay validation, tech transfer, and development initiatives to maintain industry standards; contribute within the computational protein design group to operate yeast display‑based protein discovery platforms.
Design new macromolecular therapeutics using structural and sequence analysis, and employ these in silico predictions to iteratively guide the lead development process.
Analyze, interpret, document and present data to the scientific and leadership team.
Work within a collaborative, interdisciplinary team to actively contribute to executing the vision of the company.
Qualifications
PhD (or equivalent) in bioengineering, biophysics, biochemistry, molecular biology, cell biology, or a related field.
8+ years of experience using yeast libraries to generate protein binding or therapeutic antibodies.
Experience solving problems related to peptide and protein design, modeling, and sequence/structure‑function prediction, with expertise in macromolecular modeling software such as AlphaFold, RoseTTAFold, RFdiffusion, ProteinMPNN, Gromacs, MOE, Schrödinger.
Expertise in screening and ranking antibodies (ELISA, multi‑parametric flow cytometry, BLI/OCTET).
Proven contribution to therapeutic antibody development and selection is desirable; design and validate novel biologically relevant antibodies is highly desirable.
Compensation and Benefits The expected base salary range for this position is $150,000 – $250,000 annually. Actual compensation will be based on a variety of factors, including but not limited to a candidate’s qualifications, experience, and skills.
SystImmune offers a comprehensive benefits package including:
100% paid employee premiums for medical, dental, and vision
Short‑term and long‑term disability insurance
401(k) plan with a 50% company match up to 3% and a 5‑year vesting schedule
15 PTO days per year, sick leave, and 11 paid holidays
Additional benefits and perks
Equal Opportunity SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.
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