Johnson & Johnson Innovative Medicine
Senior Principal Scientist, Protein Design - In Silico Protein and Antibody Desi
Johnson & Johnson Innovative Medicine, Spring House, Pennsylvania, United States, 19477
Senior Principal Scientist, Protein Design (In Silico Protein and Antibody Design)
At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.
Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.
Johnson & Johnson Innovative Medicine is currently seeking a Senior Principal Scientist, Protein Design, to join our In Silico Proteins team within the Therapeutics Discovery organization, with a preference for this individual to be located at one of our sites in Spring House, PA, or Cambridge, MA. Remote work options may be considered on a case‑by‑case basis.
Key Responsibilities
Work directly with wet‑lab scientists and therapeutic areas to design and optimize protein molecules for specific functions and properties, with a focus on antibody therapeutics.
Collaborate with team members across Therapeutics Discovery on the planning, prioritization, and timely delivery of designs to support multiple concurrent programs.
Serve as an In Silico Discovery Lead on diverse project teams.
Work with ML colleagues to develop and benchmark pioneering generative and discriminative models.
Model sophisticated biological systems using a variety of methods and tools to advise design methodology.
Participate in internal and external presentations, peer‑reviewed manuscripts and conference proceedings.
Qualifications Education
PhD in Biomedical Engineering, Biochemistry, Computational Biology, Computer Science, Structural Biology, Biophysics, Material Science, or other related quantitative field with at least 5 years of experience.
Experience and Skills
Advanced experience in computational protein modeling, design, structural biology, and biophysics.
Ability to lead projects in cross‑functional teams to completion in a collaborative manner.
Experience in de novo protein design and sophisticated protein design techniques, such as large‑scale backbone editing – for example, fusion design, loop design (inpainting), deletions, and extensions.
Experience with antibody and/or nanobody modeling and design.
Experience with high performance computing (on‑prem or cloud).
Knowledge of critical wet‑lab techniques used in protein engineering such as yeast display, SPR, ITC, CD spectroscopy.
Solid understanding of current machine learning architectures.
Advanced proficiency in Python and related data‑science packages such as Pandas and Numpy.
Excellent communication, reporting and team interaction skills, self‑motivated, proactive, and independent.
Experience with powerful ML packages for protein modeling and design such as AlphaFold, RosettaFold, ESMFold, ProteinMPNN, RFDiffusion, Chroma, IgFold, DeepAb, Parapred, etc.
Experience with retraining, fine‑tuning, and building ML models such as LLMs to support advanced protein design and protein property prediction tools.
Experience mentoring and leading junior scientists.
Desire for continuous learning and the ability to identify, evaluate and deploy emerging algorithms, models, and protein design workflows.
Other The preference is for this individual to be located at one of our sites in either Spring House, PA, or Cambridge, MA. Remote work options within the US may be considered on a case‑by‑case basis and if approved by the company. Travel up to 10% may be required.
Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.
Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via https://www.jnj.com/contact-us/careers, internal employees contact AskGS to be directed to your accommodation resource.
Compensation The anticipated base pay range for this position is $137,000 to $235,750. The Company maintains highly competitive, performance‑based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporation’s performance over a calendar/performance year. Bonuses are awarded at the Company’s discretion on an individual basis. Employees and/or eligible dependents may be eligible to participate in the following Company‑sponsored employee benefit programs: medical, dental, vision, life insurance, short‑ and long‑term disability, business accident insurance, and group legal insurance. Employees may be eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)).
Time Off Benefits
Vacation – up to 120 hours per calendar year.
Sick time – up to 40 hours per calendar year.
Holiday pay, including Floating Holidays – up to 13 days per calendar year of Work, Personal and Family Time – up to 40 hours per calendar year.
Required Skills None specified.
Preferred Skills
Advanced Analytics
Consulting
Critical Thinking
Data Analysis
Data Privacy Standards
Data Quality
Data Reporting
Data Savvy
Data Science
Data Visualization
Digital Fluency
Econometric Models
Mentorship
Strategic Thinking
Tactical Planning
Technical Credibility
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Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.
Johnson & Johnson Innovative Medicine is currently seeking a Senior Principal Scientist, Protein Design, to join our In Silico Proteins team within the Therapeutics Discovery organization, with a preference for this individual to be located at one of our sites in Spring House, PA, or Cambridge, MA. Remote work options may be considered on a case‑by‑case basis.
Key Responsibilities
Work directly with wet‑lab scientists and therapeutic areas to design and optimize protein molecules for specific functions and properties, with a focus on antibody therapeutics.
Collaborate with team members across Therapeutics Discovery on the planning, prioritization, and timely delivery of designs to support multiple concurrent programs.
Serve as an In Silico Discovery Lead on diverse project teams.
Work with ML colleagues to develop and benchmark pioneering generative and discriminative models.
Model sophisticated biological systems using a variety of methods and tools to advise design methodology.
Participate in internal and external presentations, peer‑reviewed manuscripts and conference proceedings.
Qualifications Education
PhD in Biomedical Engineering, Biochemistry, Computational Biology, Computer Science, Structural Biology, Biophysics, Material Science, or other related quantitative field with at least 5 years of experience.
Experience and Skills
Advanced experience in computational protein modeling, design, structural biology, and biophysics.
Ability to lead projects in cross‑functional teams to completion in a collaborative manner.
Experience in de novo protein design and sophisticated protein design techniques, such as large‑scale backbone editing – for example, fusion design, loop design (inpainting), deletions, and extensions.
Experience with antibody and/or nanobody modeling and design.
Experience with high performance computing (on‑prem or cloud).
Knowledge of critical wet‑lab techniques used in protein engineering such as yeast display, SPR, ITC, CD spectroscopy.
Solid understanding of current machine learning architectures.
Advanced proficiency in Python and related data‑science packages such as Pandas and Numpy.
Excellent communication, reporting and team interaction skills, self‑motivated, proactive, and independent.
Experience with powerful ML packages for protein modeling and design such as AlphaFold, RosettaFold, ESMFold, ProteinMPNN, RFDiffusion, Chroma, IgFold, DeepAb, Parapred, etc.
Experience with retraining, fine‑tuning, and building ML models such as LLMs to support advanced protein design and protein property prediction tools.
Experience mentoring and leading junior scientists.
Desire for continuous learning and the ability to identify, evaluate and deploy emerging algorithms, models, and protein design workflows.
Other The preference is for this individual to be located at one of our sites in either Spring House, PA, or Cambridge, MA. Remote work options within the US may be considered on a case‑by‑case basis and if approved by the company. Travel up to 10% may be required.
Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.
Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via https://www.jnj.com/contact-us/careers, internal employees contact AskGS to be directed to your accommodation resource.
Compensation The anticipated base pay range for this position is $137,000 to $235,750. The Company maintains highly competitive, performance‑based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporation’s performance over a calendar/performance year. Bonuses are awarded at the Company’s discretion on an individual basis. Employees and/or eligible dependents may be eligible to participate in the following Company‑sponsored employee benefit programs: medical, dental, vision, life insurance, short‑ and long‑term disability, business accident insurance, and group legal insurance. Employees may be eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)).
Time Off Benefits
Vacation – up to 120 hours per calendar year.
Sick time – up to 40 hours per calendar year.
Holiday pay, including Floating Holidays – up to 13 days per calendar year of Work, Personal and Family Time – up to 40 hours per calendar year.
Required Skills None specified.
Preferred Skills
Advanced Analytics
Consulting
Critical Thinking
Data Analysis
Data Privacy Standards
Data Quality
Data Reporting
Data Savvy
Data Science
Data Visualization
Digital Fluency
Econometric Models
Mentorship
Strategic Thinking
Tactical Planning
Technical Credibility
#J-18808-Ljbffr