Corvus Pharmaceuticals, Inc.
Sr. Manager/Associate Director, Process Chemistry
Corvus Pharmaceuticals, Inc., San Francisco, California, United States, 94199
Department/Group: Chemistry
Location: South San Francisco, CA
Position Type: Full time
Role and Responsibilities
Independently design synthetic strategies and use those strategies to synthesize and characterize precursor compounds, starting materials, intermediates, reference compounds, and new chemical entities
Scale up and process development of small molecules across early through late-stage phases
Design and conduct control strategies for drug substance manufacturing including impurity identification and synthesis, and fate and purge experiments
Purify and characterize molecules with standard analytical techniques (e.g. HPLC, LCMS, NMR)
Collaborate with cross functional teams of product development, QA, analytical and formulations.
Work with contract organizations and support technology transfer
Perform research and/or development in collaboration with others in chemistry and biology; make detailed observations and analyze data.
Prepare batch records, technical reports, summaries, protocols and quantitative analyses
Write and review manuscripts for publication
Provide support in corporate research and development of patent applications
Develop strategies to ensure effective achievement of scientific objectives
Uses skills to contribute to development of company objectives and principles and to achieve goals in creative and effective ways
Exercises independent judgment in selecting methods, techniques and evaluation criteria for obtaining results
Qualifications and Education Requirements
PhD in Chemistry plus 5+ years of related experience in pharmaceutical or biotechnology industry or equivalent.
Demonstrated expertise and hands‑on experience in synthetic organic chemistry process development and manufacturing.
Knowledge of regulatory (ICH, USP etc.) standards.
Experience working with CRO/CDMO partners for drug substance manufacturing.
Must possess expert knowledge of scientific principles and concepts.
A solid understanding of modern analytical techniques (NMR, HPLC, MS)
Excellent verbal and written communication skills and the ability to collaborate effectively within a multidisciplinary team
Preferred Skills
Able to manage outside vendor collaborations
Flexibility and willingness to solve problems that fall outside of immediate area of expertise
Work independently in an interdisciplinary, fast‑paced, often changing environment.
Committed to the values of integrity, accountability, transparency, and drive.
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Role and Responsibilities
Independently design synthetic strategies and use those strategies to synthesize and characterize precursor compounds, starting materials, intermediates, reference compounds, and new chemical entities
Scale up and process development of small molecules across early through late-stage phases
Design and conduct control strategies for drug substance manufacturing including impurity identification and synthesis, and fate and purge experiments
Purify and characterize molecules with standard analytical techniques (e.g. HPLC, LCMS, NMR)
Collaborate with cross functional teams of product development, QA, analytical and formulations.
Work with contract organizations and support technology transfer
Perform research and/or development in collaboration with others in chemistry and biology; make detailed observations and analyze data.
Prepare batch records, technical reports, summaries, protocols and quantitative analyses
Write and review manuscripts for publication
Provide support in corporate research and development of patent applications
Develop strategies to ensure effective achievement of scientific objectives
Uses skills to contribute to development of company objectives and principles and to achieve goals in creative and effective ways
Exercises independent judgment in selecting methods, techniques and evaluation criteria for obtaining results
Qualifications and Education Requirements
PhD in Chemistry plus 5+ years of related experience in pharmaceutical or biotechnology industry or equivalent.
Demonstrated expertise and hands‑on experience in synthetic organic chemistry process development and manufacturing.
Knowledge of regulatory (ICH, USP etc.) standards.
Experience working with CRO/CDMO partners for drug substance manufacturing.
Must possess expert knowledge of scientific principles and concepts.
A solid understanding of modern analytical techniques (NMR, HPLC, MS)
Excellent verbal and written communication skills and the ability to collaborate effectively within a multidisciplinary team
Preferred Skills
Able to manage outside vendor collaborations
Flexibility and willingness to solve problems that fall outside of immediate area of expertise
Work independently in an interdisciplinary, fast‑paced, often changing environment.
Committed to the values of integrity, accountability, transparency, and drive.
#J-18808-Ljbffr