Salubris Biotherapeutics Inc
Senior Director/Vice President, Preclinical Pharmacology & Toxicology
Salubris Biotherapeutics Inc, Gaithersburg, Maryland, us, 20883
Benefits
401(k) matching
Competitive salary
Dental insurance
Free food & snacks
Health insurance
Paid time off
Position Overview Salubris Biotherapeutics is seeking a visionary and experienced leader to join our team as
Senior Director
or
Vice President, Preclinical Pharmacology & Toxicology . This foundational leadership role offers the opportunity to further establish and lead the Preclinical Pharmacology, Pharmacometrics, and Toxicology function, driving research programs from lead optimization through IND submission.
The SD/VP will be responsible for integrating nonclinical pharmacology, toxicology, and pharmacokinetics into the company's R&D strategy, ensuring alignment with regulatory and scientific standards. This strategic leadership role guides non-clinical assessments from late research development through IND/CTA submissions and will have a significant and lasting impact on the company's scientific direction and future success.
Key Responsibilities
Strategic Program Leadership:
Serve as a key strategic leader, partnering with the CSO to shape preclinical development strategy across the portfolio. Drive the strategic vision for advancing programs from late-stage discovery through IND/CTA submission, ensuring alignment with corporate objectives and competitive positioning. Anticipate regulatory and scientific challenges, and proactively develop risk mitigation strategies to accelerate program timelines.
Preclinical Study Oversight:
Design, manage, and interpret pharmacology, PK/PD, and toxicology studies (GLP/non-GLP) to support program advancement. Oversee CRO partnerships, protocol development, study monitoring, and regulatory documentation to deliver high-quality nonclinical data packages.
Cross-Functional Integration:
Lead cross-functional collaboration with Bioanalytical, CMC, and Clinical teams to develop integrated nonclinical safety, translational science and CMC development strategies. Ensure seamless translation of preclinical findings into clinical development plans.
Scientific Excellence & Team Development:
Mentor and develop internal team members, building organizational capabilities in disease- and target-relevant efficacy studies, PK/PD/biomarker strategies, and translational approaches across cardiovascular/metabolic and oncology therapeutic areas.
Required Qualifications
PhD in Biology, Biochemistry, Biomedical Sciences, Pharmacology, Toxicology, Pharmaceutical Sciences, or related scientific discipline
10+ years of relevant pharmaceutical/biotechnology industry experience, including 5+ years in a leadership capacity within preclinical pharmacology, toxicology, and/or DMPK
Demonstrated ability as program lead to advance programs from lead optimization to IND with complex biologics, such as antibodies, and/or antibody conjugates (ADCs, AOCs)
Deep understanding of in vivo pharmacology and toxicology.
Solid working knowledge in bioanalysis, PK/PD, and DMPK. Relevant experience with both biologics and small molecules is a strong plus.
Experience delivering high-quality preclinical/nonclinical data packages for drug candidate selection and IND-enabling studies.
Experience with cardiovascular/metabolic therapeutic area or oncology preferred.
Skills & Competencies
Strong strategic thinking and scientific judgment with excellent problem-solving capabilities
Excellent communication skills with the ability to distill complex scientific analyses into clear, actionable recommendations for diverse audiences
Strong interpersonal skills with the ability to motivate, influence, and lead cross-functional teams in a matrixed environment
Demonstrated ability to work collaboratively and influence at all levels of the organization
Independent, self-motivated leader with the ability to work in a fast-paced, team-based drug discovery and development environment
About Salubris Biotherapeutics Salubris Biotherapeutics, Inc. (or SalubrisBio) is a clinical-stage biotechnology company dedicated to the discovery and global development of novel biologic therapeutics for the treatment of cancer, cardiovascular, and metabolic diseases. We are advancing a robust complex biologics pipeline including antibody-drug-conjugate and antibody-fusion programs, with a commitment to transforming patient outcomes through scientific excellence and innovation. We offer a competitive compensation package including base salary, performance bonus, equity participation, and comprehensive benefits. SalubrisBio is an equal opportunity employer committed to diversity and inclusion in the workplace.
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401(k) matching
Competitive salary
Dental insurance
Free food & snacks
Health insurance
Paid time off
Position Overview Salubris Biotherapeutics is seeking a visionary and experienced leader to join our team as
Senior Director
or
Vice President, Preclinical Pharmacology & Toxicology . This foundational leadership role offers the opportunity to further establish and lead the Preclinical Pharmacology, Pharmacometrics, and Toxicology function, driving research programs from lead optimization through IND submission.
The SD/VP will be responsible for integrating nonclinical pharmacology, toxicology, and pharmacokinetics into the company's R&D strategy, ensuring alignment with regulatory and scientific standards. This strategic leadership role guides non-clinical assessments from late research development through IND/CTA submissions and will have a significant and lasting impact on the company's scientific direction and future success.
Key Responsibilities
Strategic Program Leadership:
Serve as a key strategic leader, partnering with the CSO to shape preclinical development strategy across the portfolio. Drive the strategic vision for advancing programs from late-stage discovery through IND/CTA submission, ensuring alignment with corporate objectives and competitive positioning. Anticipate regulatory and scientific challenges, and proactively develop risk mitigation strategies to accelerate program timelines.
Preclinical Study Oversight:
Design, manage, and interpret pharmacology, PK/PD, and toxicology studies (GLP/non-GLP) to support program advancement. Oversee CRO partnerships, protocol development, study monitoring, and regulatory documentation to deliver high-quality nonclinical data packages.
Cross-Functional Integration:
Lead cross-functional collaboration with Bioanalytical, CMC, and Clinical teams to develop integrated nonclinical safety, translational science and CMC development strategies. Ensure seamless translation of preclinical findings into clinical development plans.
Scientific Excellence & Team Development:
Mentor and develop internal team members, building organizational capabilities in disease- and target-relevant efficacy studies, PK/PD/biomarker strategies, and translational approaches across cardiovascular/metabolic and oncology therapeutic areas.
Required Qualifications
PhD in Biology, Biochemistry, Biomedical Sciences, Pharmacology, Toxicology, Pharmaceutical Sciences, or related scientific discipline
10+ years of relevant pharmaceutical/biotechnology industry experience, including 5+ years in a leadership capacity within preclinical pharmacology, toxicology, and/or DMPK
Demonstrated ability as program lead to advance programs from lead optimization to IND with complex biologics, such as antibodies, and/or antibody conjugates (ADCs, AOCs)
Deep understanding of in vivo pharmacology and toxicology.
Solid working knowledge in bioanalysis, PK/PD, and DMPK. Relevant experience with both biologics and small molecules is a strong plus.
Experience delivering high-quality preclinical/nonclinical data packages for drug candidate selection and IND-enabling studies.
Experience with cardiovascular/metabolic therapeutic area or oncology preferred.
Skills & Competencies
Strong strategic thinking and scientific judgment with excellent problem-solving capabilities
Excellent communication skills with the ability to distill complex scientific analyses into clear, actionable recommendations for diverse audiences
Strong interpersonal skills with the ability to motivate, influence, and lead cross-functional teams in a matrixed environment
Demonstrated ability to work collaboratively and influence at all levels of the organization
Independent, self-motivated leader with the ability to work in a fast-paced, team-based drug discovery and development environment
About Salubris Biotherapeutics Salubris Biotherapeutics, Inc. (or SalubrisBio) is a clinical-stage biotechnology company dedicated to the discovery and global development of novel biologic therapeutics for the treatment of cancer, cardiovascular, and metabolic diseases. We are advancing a robust complex biologics pipeline including antibody-drug-conjugate and antibody-fusion programs, with a commitment to transforming patient outcomes through scientific excellence and innovation. We offer a competitive compensation package including base salary, performance bonus, equity participation, and comprehensive benefits. SalubrisBio is an equal opportunity employer committed to diversity and inclusion in the workplace.
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