GlaxoSmithKline
Director, Translational Lead Respiratory
GlaxoSmithKline, Waltham, Massachusetts, United States, 02254
Business Introduction
At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting‑edge technology to transform people’s lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients’ needs and have the highest probability of success. We’re uniting science, technology, and talent to get ahead of disease together.
Position Summary The Respiratory, Immunology and Inflammation Translational Unit (RIITU), within RIIRU therapy area is accountable for end‑to‑end disease area translational science to inform therapy area and program level biomarker strategies (from preclinical to launch) to increase the probability of success from preclinical to clinical transitions and enable earlier and higher confidence asset related decisions. This includes generation of foundational data as well as disease biomarker development and validation that allow timely deployment of tools/biomarkers to support Proof of Mechanism (PoM), signs of clinical efficacy, Proof of Concept (PoC), and pairing Mechanisms of Action (MoAs) with patient subtypes to predict responder populations. We are looking for a dynamic individual to excel in the following responsibilities.
Key Responsibilities
Partner with Clinical, Research Technologies and Development teams with focus on Respiratory portfolio to identify, establish biomarkers for decision making throughout clinical development phases and aligned with overall R&D goals. This includes identification, prioritization and validation of disease relevant biomarkers, mechanistic/surrogate biomarkers, patient stratification, and differentiated response prediction, their deployment into clinical studies and interpretation of data/results.
Provide strategic leadership contributing to deep understanding of disease areas enabling the development and execution of translational research disease strategies to support the discovery and development of novel differentiated therapeutics including evaluation and diligence of business development opportunities.
Evaluate novel techniques and technologies (i.e. spatial transcriptomics) to inform translational initiatives, biomarker development and validation working in collaboration with platform teams and within a multi‑functional matrix environment.
Identify and guide validation of human assays (cells, tissues and organs) to enhance human translation and predictive value through the application of resources such as the Human Cell Atlas, disease tissue multi‑omics data and genetic resources.
Collaborate closely with cross‑functional teams including Translational, Disease Teams, Human Genetics & Genomics, biology groups, biomarker platforms, Medicine Development Teams, HBSM, data‑sciences, regulatory affairs, business development and commercial to ensure seamless integration of translational research and biomarker strategies across the drug development lifecycle.
Establish and maintain strategic collaborations with academic institutions, CROs and other external partners to access cutting‑edge technologies, tools, reagents, biosamples, biomarker expertise, and research capabilities.
Contribute to evaluation and diligence of business development opportunities.
Provide mentorship, guidance, and professional development opportunities to ensure a high‑performing and motivated team.
Manage disease and project level resources, budgets, and timelines to ensure the successful execution of projects and achievement of milestones and RITU objectives.
Represent RITU at portfolio governance reviews providing critical input to pipeline and investment decision making.
Why You? Basic Qualification
Ph.D. in a relevant scientific discipline (e.g., Cell/Molecular Biology, Genetics, Pharmacology, Physical Chemistry or related field)
Extensive experience in translational science and biomarker development ideally within the pharmaceutical or biotechnology industry.
Recognised translational/biomarker expert in scientific community through publications and contributions to the field.
Experience of translation and biomarkers implementation in Respiratory indications
Experience of working in a clinical trial setting, working as part of a clinical study and experience of authoring and oversight of clinical and regulatory documents
Preferred Qualification
Knowledge of regulatory requirements, industry standards, best practices and compliance considerations in Translational Research and biomarker development and validation.
Broad knowledge in technologies and methods used in translational research.
Proven track record of program decision making through implementing biomarker strategies and delivering translational science insights in support of drug progression through clinical transition milestones.
Experience leading/managing external collaborations and evaluation of business development opportunities.
Strong management skills, with the ability to prioritize and manage multiple objectives to meet timelines while maintaining attention to detail and high‑performance standards.
Excellent inclusive matrix leadership skills, with the ability to create psychological safety, inspire and motivate a team towards achieving common goals.
Working Model This role is based in the United Kingdom or the United States and follows a hybrid working model. You will be expected to work on site regularly to collaborate with your team and partners.
How to apply If this role inspires you, please apply with your CV and a short cover note describing a recent translational achievement. Tell us what you did, why it mattered, and the impact it had. We welcome people from all backgrounds and value inclusion in how we hire and lead. We look forward to hearing from you.
Salary Annual base salary ranges for new hires in this position vary by location and level, with additional bonus and shared‑long‑term incentive program eligibility.
Why GSK? Uniting science, technology and talent to get ahead of disease together.
GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.
People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.
GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.
We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.
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Position Summary The Respiratory, Immunology and Inflammation Translational Unit (RIITU), within RIIRU therapy area is accountable for end‑to‑end disease area translational science to inform therapy area and program level biomarker strategies (from preclinical to launch) to increase the probability of success from preclinical to clinical transitions and enable earlier and higher confidence asset related decisions. This includes generation of foundational data as well as disease biomarker development and validation that allow timely deployment of tools/biomarkers to support Proof of Mechanism (PoM), signs of clinical efficacy, Proof of Concept (PoC), and pairing Mechanisms of Action (MoAs) with patient subtypes to predict responder populations. We are looking for a dynamic individual to excel in the following responsibilities.
Key Responsibilities
Partner with Clinical, Research Technologies and Development teams with focus on Respiratory portfolio to identify, establish biomarkers for decision making throughout clinical development phases and aligned with overall R&D goals. This includes identification, prioritization and validation of disease relevant biomarkers, mechanistic/surrogate biomarkers, patient stratification, and differentiated response prediction, their deployment into clinical studies and interpretation of data/results.
Provide strategic leadership contributing to deep understanding of disease areas enabling the development and execution of translational research disease strategies to support the discovery and development of novel differentiated therapeutics including evaluation and diligence of business development opportunities.
Evaluate novel techniques and technologies (i.e. spatial transcriptomics) to inform translational initiatives, biomarker development and validation working in collaboration with platform teams and within a multi‑functional matrix environment.
Identify and guide validation of human assays (cells, tissues and organs) to enhance human translation and predictive value through the application of resources such as the Human Cell Atlas, disease tissue multi‑omics data and genetic resources.
Collaborate closely with cross‑functional teams including Translational, Disease Teams, Human Genetics & Genomics, biology groups, biomarker platforms, Medicine Development Teams, HBSM, data‑sciences, regulatory affairs, business development and commercial to ensure seamless integration of translational research and biomarker strategies across the drug development lifecycle.
Establish and maintain strategic collaborations with academic institutions, CROs and other external partners to access cutting‑edge technologies, tools, reagents, biosamples, biomarker expertise, and research capabilities.
Contribute to evaluation and diligence of business development opportunities.
Provide mentorship, guidance, and professional development opportunities to ensure a high‑performing and motivated team.
Manage disease and project level resources, budgets, and timelines to ensure the successful execution of projects and achievement of milestones and RITU objectives.
Represent RITU at portfolio governance reviews providing critical input to pipeline and investment decision making.
Why You? Basic Qualification
Ph.D. in a relevant scientific discipline (e.g., Cell/Molecular Biology, Genetics, Pharmacology, Physical Chemistry or related field)
Extensive experience in translational science and biomarker development ideally within the pharmaceutical or biotechnology industry.
Recognised translational/biomarker expert in scientific community through publications and contributions to the field.
Experience of translation and biomarkers implementation in Respiratory indications
Experience of working in a clinical trial setting, working as part of a clinical study and experience of authoring and oversight of clinical and regulatory documents
Preferred Qualification
Knowledge of regulatory requirements, industry standards, best practices and compliance considerations in Translational Research and biomarker development and validation.
Broad knowledge in technologies and methods used in translational research.
Proven track record of program decision making through implementing biomarker strategies and delivering translational science insights in support of drug progression through clinical transition milestones.
Experience leading/managing external collaborations and evaluation of business development opportunities.
Strong management skills, with the ability to prioritize and manage multiple objectives to meet timelines while maintaining attention to detail and high‑performance standards.
Excellent inclusive matrix leadership skills, with the ability to create psychological safety, inspire and motivate a team towards achieving common goals.
Working Model This role is based in the United Kingdom or the United States and follows a hybrid working model. You will be expected to work on site regularly to collaborate with your team and partners.
How to apply If this role inspires you, please apply with your CV and a short cover note describing a recent translational achievement. Tell us what you did, why it mattered, and the impact it had. We welcome people from all backgrounds and value inclusion in how we hire and lead. We look forward to hearing from you.
Salary Annual base salary ranges for new hires in this position vary by location and level, with additional bonus and shared‑long‑term incentive program eligibility.
Why GSK? Uniting science, technology and talent to get ahead of disease together.
GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.
People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.
GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.
We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.
#J-18808-Ljbffr