Flagship Pioneering
FL111 | Cambridge, MA Associate Director, In Vivo Pharmacology & Translational S
Flagship Pioneering, Cambridge, Massachusetts, us, 02140
Location
Cambridge, MA USA
Company Summary Flagship Labs 111 Inc. (FL111) is a privately held, early‑stage biotechnology company pioneering a novel platform harnessing innovations in chemistry and machine learning to address challenging biology. FL111 is backed by Flagship Pioneering, bringing the courage, vision, and resources to guide FL111 from platform validation to patient impact. We are seeking collaborative, creative and relentless problem solvers that share our passion for impact.
Position Summary Associate Director, In Vivo Pharmacology & Translational Science. Lead all in vivo activities from early discovery throughclinical development. Own the design, execution, and interpretation of in vivo PK, PD, and efficacy studies, focusing on oncology and small‑molecule modalities. Build and scale in vivo capabilities, establish best practices, and serve as the in vivo leader at FL111.
Key Responsibilities
Project leadership: serve as the in vivo lead on project teams, accountable for end‑to‑end planning, execution, and delivery of all in vivo PK, PD, and efficacy studies.
Study design and execution: develop and execute in vivo studies to evaluate compound exposure, target engagement, biomarkers, and anti‑tumor activity across oncology models and small molecule modalities; hands‑on execution.
CRO management and operations: lead day‑to‑day management of external in vivo work at CROs, including protocol review, study monitoring, data quality oversight, and vendor qualification/onboarding.
Collaborate closely with Chemistry, DMPK, and Biology teams to refine compound design and formulation based on integrated PK/PD/efficacy data.
Documentation & communication: establish fit‑for‑purpose in vivo workflows and SOPs, document experiments and results, and communicate scientific results effectively through clear presentations.
Qualifications & Skills
Ph.D./M.D. with 5‑10+ years of industry experience in preclinical development of small molecule modalities.
Deep expertise in oncology and cancer biology, specifically in designing and executing studies using diverse in vivo oncology models (e.g., CDX, PDX, humanized, syngeneic).
Expertise in preclinical characterization of heterobifunctional small molecules (e.g., PROTACs).
Proven ability to lead projects, integrating PK, PD, and efficacy data to drive compound optimization and Go/No Go decisions.
Extensive experience managing external in vivo work at CROs, including experimental design, study monitoring, and data quality oversight.
EEO Statement Flagship Pioneering is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
Additional Information Salary range: $157,000 – $198,000. Compensation based on qualifications, skills, competencies, and experience. Benefits include healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits.
Additional Notes At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way.
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Company Summary Flagship Labs 111 Inc. (FL111) is a privately held, early‑stage biotechnology company pioneering a novel platform harnessing innovations in chemistry and machine learning to address challenging biology. FL111 is backed by Flagship Pioneering, bringing the courage, vision, and resources to guide FL111 from platform validation to patient impact. We are seeking collaborative, creative and relentless problem solvers that share our passion for impact.
Position Summary Associate Director, In Vivo Pharmacology & Translational Science. Lead all in vivo activities from early discovery throughclinical development. Own the design, execution, and interpretation of in vivo PK, PD, and efficacy studies, focusing on oncology and small‑molecule modalities. Build and scale in vivo capabilities, establish best practices, and serve as the in vivo leader at FL111.
Key Responsibilities
Project leadership: serve as the in vivo lead on project teams, accountable for end‑to‑end planning, execution, and delivery of all in vivo PK, PD, and efficacy studies.
Study design and execution: develop and execute in vivo studies to evaluate compound exposure, target engagement, biomarkers, and anti‑tumor activity across oncology models and small molecule modalities; hands‑on execution.
CRO management and operations: lead day‑to‑day management of external in vivo work at CROs, including protocol review, study monitoring, data quality oversight, and vendor qualification/onboarding.
Collaborate closely with Chemistry, DMPK, and Biology teams to refine compound design and formulation based on integrated PK/PD/efficacy data.
Documentation & communication: establish fit‑for‑purpose in vivo workflows and SOPs, document experiments and results, and communicate scientific results effectively through clear presentations.
Qualifications & Skills
Ph.D./M.D. with 5‑10+ years of industry experience in preclinical development of small molecule modalities.
Deep expertise in oncology and cancer biology, specifically in designing and executing studies using diverse in vivo oncology models (e.g., CDX, PDX, humanized, syngeneic).
Expertise in preclinical characterization of heterobifunctional small molecules (e.g., PROTACs).
Proven ability to lead projects, integrating PK, PD, and efficacy data to drive compound optimization and Go/No Go decisions.
Extensive experience managing external in vivo work at CROs, including experimental design, study monitoring, and data quality oversight.
EEO Statement Flagship Pioneering is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
Additional Information Salary range: $157,000 – $198,000. Compensation based on qualifications, skills, competencies, and experience. Benefits include healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits.
Additional Notes At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way.
#J-18808-Ljbffr