Executive Director, Global Medical Affairs, GI
Summit Therapeutics, Inc., Princeton, New Jersey, us, 08543
Executive Director, Global Medical Affairs, GI
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Executive Director, Global Medical Affairs, GI
role at
Summit Therapeutics, Inc.
About Summit Summit Therapeutics Inc. is a biopharmaceutical oncology company with a mission focused on improving quality of life, increasing potential duration of life, and resolving serious unmet medical needs. At Summit, we believe in building a team of world class professionals who are passionate about this mission, and it is our people who drive this mission to reality. Summit’s core values include integrity, passion for excellence, purposeful urgency, collaboration, and our commitment to people. Our employees are truly the heart and soul of our culture, and they are invaluable in shaping our journey toward excellence.
Clinical Studies
Non‑small Cell Lung Cancer (NSCLC):
HARMONi: Phase 3 clinical study which was intended to evaluate ivonescimab combined with chemotherapy compared to placebo plus chemotherapy in patients with EGFR‑mutated, locally advanced or metastatic non‑squamous NSCLC who were previously treated with a 3rd generation EGFR TKI.
HARMONi‑3: Phase 3 clinical study which is intended to evaluate ivonescimab combined with chemotherapy compared to pembrolizumab combined with chemotherapy in patients with first‑line metastatic NSCLC.
HARMONi‑7: Phase 3 clinical study which is intended to evaluate ivonescimab monotherapy compared to pembrolizumab monotherapy in patients with first‑line metastatic NSCLC.
Colorectal Cancer (CRC):
HARMONi‑GI3: Phase 3 clinical study intended to evaluate ivonescimab in combination with chemotherapy compared with bevacizumab plus chemotherapy.
Ivonescimab is an investigational therapy not presently approved by any regulatory authority other than China’s National Medical Products Administration (NMPA). Summit is headquartered in Miami, Florida, and has additional offices in California, New Jersey, the UK, and Ireland.
Overview of Role The Executive Director, Medical Affairs, GI is a key leader and a subject matter expert responsible for shaping and executing the medical affairs strategy in GI cancers. This role oversees the development and implementation of medical affairs plans for lung‑related indications, including launch excellence for multiple indications, lifecycle management, and scientific engagement. The Executive Director will collaborate within the medical affairs department and cross‑functionally with Clinical Development, Regulatory Affairs, Commercial, and Market Access teams to ensure effective, compliant, and impactful dissemination of data, education on disease and therapeutic information and interactions with healthcare professionals, key opinion leaders, and decision makers. Recent, hands‑on experience in GI cancers, either in clinical practice or within pharmaceutical companies, is essential.
Role and Responsibilities
Strategic Leadership
Develop and lead the US medical affairs strategy for GI cancers, ensuring alignment with global medical, clinical, and commercialization objectives.
Oversee the design, execution, and reporting of medical activities supporting the launch and lifecycle management.
Foster a culture of high performance, collaboration, skills development, and scientific excellence across the medical affairs team.
Team Leadership
Lead a high‑performance matrixed team grounded in scientific rigor and integrity.
Mentor, coach, and develop others, ensuring effective coverage and execution of medical initiatives.
Scientific Engagement & Insight Generation
Establish and maintain relationships with KOLs, HCPs, and other external stakeholders to support scientific exchange and gather actionable insights.
Ensure effective communication of scientific data and information to external stakeholders, representing Summit Therapeutics at scientific conferences, meetings, and other events.
Oversee the development and execution of pre‑launch medical education programs, strategic publications, and data generation initiatives.
Cross‑functional Collaboration
Collaborate with Clinical Development, Regulatory, Commercial, and other internal stakeholders to ensure strategic integration and alignment of medical activities.
Compliance & Reporting
Ensure all medical affairs activities comply with regulatory and company policies.
Monitor and report on activities, performance metrics, and outcomes to senior leadership.
Participate in the development and adherence to departmental SOPs and ensure all activities are legally compliant and conducted according to company standards.
All other duties as assigned
Education
Advanced scientific degree (MD, PharmD, PhD) required.
Experience
Minimum of 12+ years progressive Medical Affairs or related experience, with at least 5+ years in a leadership role.
Significant recent experience in GI cancers, either in clinical practice or within pharmaceutical/biotech companies, is required.
Proven track record of supporting product launches, building and optimizing medical affairs teams, and managing through leaders.
Experience in a fast‑paced, evolving environment preferred.
Skills & Abilities
Excellent leadership, communication, and stakeholder management skills.
Strong analytical and strategic thinking abilities.
Demonstrates resilience, composure, and effective decision‑making in a dynamic and challenging environment.
Ability to thrive in a matrixed, cross‑functional environment.
Demonstrated ability to motivate, develop, and retain high‑performing teams.
Willingness to travel up to 40% as needed.
Additional Requirements
Proficient user of standard MS Office suite (Word, Excel), experience using electronic document management systems, and document review tools.
Must be able to effectively multi‑task and manage time‑sensitive and highly confidential documents.
Work in a fast‑paced, demanding, and collaborative environment.
The pay range for this role is $231,000-$289,000 annually. Actual compensation packages are based on several factors that are unique to each candidate, including but not limited to skill set, depth of experience, certifications, and specific work location. This may be different in other locations due to differences in the cost of labor. The total compensation package for this position may also include bonus, stock, benefits and/or other applicable variable compensation.
Summit does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact Summit’s Talent Acquisition team at recruiting@smmttx.com to obtain prior written authorization before referring any candidates to Summit.
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Executive Director, Global Medical Affairs, GI
role at
Summit Therapeutics, Inc.
About Summit Summit Therapeutics Inc. is a biopharmaceutical oncology company with a mission focused on improving quality of life, increasing potential duration of life, and resolving serious unmet medical needs. At Summit, we believe in building a team of world class professionals who are passionate about this mission, and it is our people who drive this mission to reality. Summit’s core values include integrity, passion for excellence, purposeful urgency, collaboration, and our commitment to people. Our employees are truly the heart and soul of our culture, and they are invaluable in shaping our journey toward excellence.
Clinical Studies
Non‑small Cell Lung Cancer (NSCLC):
HARMONi: Phase 3 clinical study which was intended to evaluate ivonescimab combined with chemotherapy compared to placebo plus chemotherapy in patients with EGFR‑mutated, locally advanced or metastatic non‑squamous NSCLC who were previously treated with a 3rd generation EGFR TKI.
HARMONi‑3: Phase 3 clinical study which is intended to evaluate ivonescimab combined with chemotherapy compared to pembrolizumab combined with chemotherapy in patients with first‑line metastatic NSCLC.
HARMONi‑7: Phase 3 clinical study which is intended to evaluate ivonescimab monotherapy compared to pembrolizumab monotherapy in patients with first‑line metastatic NSCLC.
Colorectal Cancer (CRC):
HARMONi‑GI3: Phase 3 clinical study intended to evaluate ivonescimab in combination with chemotherapy compared with bevacizumab plus chemotherapy.
Ivonescimab is an investigational therapy not presently approved by any regulatory authority other than China’s National Medical Products Administration (NMPA). Summit is headquartered in Miami, Florida, and has additional offices in California, New Jersey, the UK, and Ireland.
Overview of Role The Executive Director, Medical Affairs, GI is a key leader and a subject matter expert responsible for shaping and executing the medical affairs strategy in GI cancers. This role oversees the development and implementation of medical affairs plans for lung‑related indications, including launch excellence for multiple indications, lifecycle management, and scientific engagement. The Executive Director will collaborate within the medical affairs department and cross‑functionally with Clinical Development, Regulatory Affairs, Commercial, and Market Access teams to ensure effective, compliant, and impactful dissemination of data, education on disease and therapeutic information and interactions with healthcare professionals, key opinion leaders, and decision makers. Recent, hands‑on experience in GI cancers, either in clinical practice or within pharmaceutical companies, is essential.
Role and Responsibilities
Strategic Leadership
Develop and lead the US medical affairs strategy for GI cancers, ensuring alignment with global medical, clinical, and commercialization objectives.
Oversee the design, execution, and reporting of medical activities supporting the launch and lifecycle management.
Foster a culture of high performance, collaboration, skills development, and scientific excellence across the medical affairs team.
Team Leadership
Lead a high‑performance matrixed team grounded in scientific rigor and integrity.
Mentor, coach, and develop others, ensuring effective coverage and execution of medical initiatives.
Scientific Engagement & Insight Generation
Establish and maintain relationships with KOLs, HCPs, and other external stakeholders to support scientific exchange and gather actionable insights.
Ensure effective communication of scientific data and information to external stakeholders, representing Summit Therapeutics at scientific conferences, meetings, and other events.
Oversee the development and execution of pre‑launch medical education programs, strategic publications, and data generation initiatives.
Cross‑functional Collaboration
Collaborate with Clinical Development, Regulatory, Commercial, and other internal stakeholders to ensure strategic integration and alignment of medical activities.
Compliance & Reporting
Ensure all medical affairs activities comply with regulatory and company policies.
Monitor and report on activities, performance metrics, and outcomes to senior leadership.
Participate in the development and adherence to departmental SOPs and ensure all activities are legally compliant and conducted according to company standards.
All other duties as assigned
Education
Advanced scientific degree (MD, PharmD, PhD) required.
Experience
Minimum of 12+ years progressive Medical Affairs or related experience, with at least 5+ years in a leadership role.
Significant recent experience in GI cancers, either in clinical practice or within pharmaceutical/biotech companies, is required.
Proven track record of supporting product launches, building and optimizing medical affairs teams, and managing through leaders.
Experience in a fast‑paced, evolving environment preferred.
Skills & Abilities
Excellent leadership, communication, and stakeholder management skills.
Strong analytical and strategic thinking abilities.
Demonstrates resilience, composure, and effective decision‑making in a dynamic and challenging environment.
Ability to thrive in a matrixed, cross‑functional environment.
Demonstrated ability to motivate, develop, and retain high‑performing teams.
Willingness to travel up to 40% as needed.
Additional Requirements
Proficient user of standard MS Office suite (Word, Excel), experience using electronic document management systems, and document review tools.
Must be able to effectively multi‑task and manage time‑sensitive and highly confidential documents.
Work in a fast‑paced, demanding, and collaborative environment.
The pay range for this role is $231,000-$289,000 annually. Actual compensation packages are based on several factors that are unique to each candidate, including but not limited to skill set, depth of experience, certifications, and specific work location. This may be different in other locations due to differences in the cost of labor. The total compensation package for this position may also include bonus, stock, benefits and/or other applicable variable compensation.
Summit does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact Summit’s Talent Acquisition team at recruiting@smmttx.com to obtain prior written authorization before referring any candidates to Summit.
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