Role Summary
Centessa Pharmaceuticals is seeking an experienced Director of Pharmaceutical Sciences to establish and lead a critical function supporting early-stage drug development. This role will provide technical expertise in physicochemical characterization, pre-formulation development, and dose formulation analysis across the portfolio. The Director will ensure robust analytical and formulation support from Candidate Selection through IND-enabling studies, bridging gaps between Non-Clinical and CMC teams to drive efficiency and compliance. Responsibilities
Lead early-stage physicochemical characterization of drug candidates during Candidate Selection through IND stages. Oversee pre-formulation activities to support pharmacology, DMPK, and toxicology studies. Manage dose formulation analysis for non-clinical studies, ensuring accuracy and compliance with regulatory expectations. Develop and implement processes for analytical verification of formulations, including stability and concentration checks for research and GLP/non-GLP toxicology studies. Collaborate closely with Non-Clinical and CMC teams to optimize resource allocation and ensure timely delivery of formulation and analytical data. Serve as subject matter expert for pharmaceutical sciences, advising on formulation strategies and analytical methodologies. Support regulatory submissions by providing high-quality data and addressing formulation-related questions. Build and maintain relationships with CDMOs and external partners to ensure best practices and scalability. Qualifications
Advanced degree (Ph.D. or M.S.) in Pharmaceutical Sciences, Chemistry, or related discipline. 10+ years of experience in pharmaceutical development, with a focus on analytical and formulation sciences. Proven track record in early-stage drug development, including IND-enabling activities. Strong understanding of dose formulation analysis, stability studies, and regulatory requirements for non-clinical and clinical phases. Experience managing cross-functional teams and external vendors (CDMOs). Excellent problem-solving, organizational, and communication skills. Education
Advanced degree (Ph.D. or M.S.) in Pharmaceutical Sciences, Chemistry, or related discipline. Additional Requirements
Remote role based in the US with approximately 15% travel.
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Centessa Pharmaceuticals is seeking an experienced Director of Pharmaceutical Sciences to establish and lead a critical function supporting early-stage drug development. This role will provide technical expertise in physicochemical characterization, pre-formulation development, and dose formulation analysis across the portfolio. The Director will ensure robust analytical and formulation support from Candidate Selection through IND-enabling studies, bridging gaps between Non-Clinical and CMC teams to drive efficiency and compliance. Responsibilities
Lead early-stage physicochemical characterization of drug candidates during Candidate Selection through IND stages. Oversee pre-formulation activities to support pharmacology, DMPK, and toxicology studies. Manage dose formulation analysis for non-clinical studies, ensuring accuracy and compliance with regulatory expectations. Develop and implement processes for analytical verification of formulations, including stability and concentration checks for research and GLP/non-GLP toxicology studies. Collaborate closely with Non-Clinical and CMC teams to optimize resource allocation and ensure timely delivery of formulation and analytical data. Serve as subject matter expert for pharmaceutical sciences, advising on formulation strategies and analytical methodologies. Support regulatory submissions by providing high-quality data and addressing formulation-related questions. Build and maintain relationships with CDMOs and external partners to ensure best practices and scalability. Qualifications
Advanced degree (Ph.D. or M.S.) in Pharmaceutical Sciences, Chemistry, or related discipline. 10+ years of experience in pharmaceutical development, with a focus on analytical and formulation sciences. Proven track record in early-stage drug development, including IND-enabling activities. Strong understanding of dose formulation analysis, stability studies, and regulatory requirements for non-clinical and clinical phases. Experience managing cross-functional teams and external vendors (CDMOs). Excellent problem-solving, organizational, and communication skills. Education
Advanced degree (Ph.D. or M.S.) in Pharmaceutical Sciences, Chemistry, or related discipline. Additional Requirements
Remote role based in the US with approximately 15% travel.
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