Role Summary
Director - Heart Failure Research leads the strategic vision for heart failure drug discovery and development programs from target identification through IND-enabling studies. The role directs design, execution, and interpretation of in vivo and in vitro pharmacology studies to assess efficacy, PK, PD, and safety of therapeutic candidates. It requires identifying robust animal models of heart failure (HFpEF and HFrEF) and other cardiovascular diseases, and serving as a subject matter expert on heart failure biology, pathology, current treatments, and next-generation therapeutics. The position requires staying current with scientific literature and external progress to keep research innovative and competitive. Responsibilities
Provide strategic vision and direction for heart failure drug discovery and development programs from target identification through IND-enabling studies. Lead and advise on the design, execution, and interpretation of in vivo and in vitro pharmacology studies to assess efficacy, PK, PD, and safety of therapeutic candidates with the team. Identify robust animal models of heart failure (including HFpEF and HFrEF) and other cardiovascular diseases using internal and external resources. Serve as a subject matter expert on heart failure biology, pathology, current treatments and next generation approaches to therapeutics. Stay current with scientific literature, technology advancements, and external competitor progress to ensure the company's research remains innovative and competitive. Team and Project Management
Lead, mentor, and manage a team of junior and senior scientists, fostering a collaborative, high-performing, and innovative culture. Manage strategies, priorities, timelines and resource allocation to ensure program achievements are met efficiently. Develop comprehensive project plans and risk mitigation strategies to address scientific and operational challenges. Communicate program progress, risks, and results to senior management and cross-functional partners. Enable outsourcing activities with contract research organizations (CROs) for specialized studies, ensuring quality and prompt execution. Collaboration and Strategy
Collaborate with cross-functional teams, including medicinal chemistry/genetic medicines/bioproducts, toxicology/ADME, bioinformatics, and regulatory affairs, to integrate data and drive program strategies. Represent the preclinical team in external meetings with scientific experts, key opinion leaders, and potential partners. Contribute pharmacology data to regulatory filings, including Investigational New Drug (IND) submissions. Support business development efforts by evaluating external opportunities for potential in-licensing. Qualifications
Required: Ph.D. in cardiovascular biology, pharmacology, molecular biology, or a related field. Required: 5+ years of industry experience in preclinical drug discovery and development, with a proven track record of advancing therapeutic programs. Required: Strong expertise in heart failure, including a deep understanding of its pathophysiology, preclinical models, and current therapeutic landscape. Skills
Preferred: Demonstrated leadership and people-management skills, with experience mentoring and developing scientific talent. Preferred: Ability to make data-driven decisions and find innovative solutions to overcome scientific and operational obstacles. Preferred: Strong project management skills, including the ability to manage complex research programs with multiple workstreams. Preferred: Excellent written and verbal communication skills, with the ability to present complex scientific data to diverse audiences. Preferred: Strong interpersonal skills for effective collaboration with internal teams, external partners, and vendors. Education
Ph.D. in cardiovascular biology, pharmacology, molecular biology, or a related field
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Director - Heart Failure Research leads the strategic vision for heart failure drug discovery and development programs from target identification through IND-enabling studies. The role directs design, execution, and interpretation of in vivo and in vitro pharmacology studies to assess efficacy, PK, PD, and safety of therapeutic candidates. It requires identifying robust animal models of heart failure (HFpEF and HFrEF) and other cardiovascular diseases, and serving as a subject matter expert on heart failure biology, pathology, current treatments, and next-generation therapeutics. The position requires staying current with scientific literature and external progress to keep research innovative and competitive. Responsibilities
Provide strategic vision and direction for heart failure drug discovery and development programs from target identification through IND-enabling studies. Lead and advise on the design, execution, and interpretation of in vivo and in vitro pharmacology studies to assess efficacy, PK, PD, and safety of therapeutic candidates with the team. Identify robust animal models of heart failure (including HFpEF and HFrEF) and other cardiovascular diseases using internal and external resources. Serve as a subject matter expert on heart failure biology, pathology, current treatments and next generation approaches to therapeutics. Stay current with scientific literature, technology advancements, and external competitor progress to ensure the company's research remains innovative and competitive. Team and Project Management
Lead, mentor, and manage a team of junior and senior scientists, fostering a collaborative, high-performing, and innovative culture. Manage strategies, priorities, timelines and resource allocation to ensure program achievements are met efficiently. Develop comprehensive project plans and risk mitigation strategies to address scientific and operational challenges. Communicate program progress, risks, and results to senior management and cross-functional partners. Enable outsourcing activities with contract research organizations (CROs) for specialized studies, ensuring quality and prompt execution. Collaboration and Strategy
Collaborate with cross-functional teams, including medicinal chemistry/genetic medicines/bioproducts, toxicology/ADME, bioinformatics, and regulatory affairs, to integrate data and drive program strategies. Represent the preclinical team in external meetings with scientific experts, key opinion leaders, and potential partners. Contribute pharmacology data to regulatory filings, including Investigational New Drug (IND) submissions. Support business development efforts by evaluating external opportunities for potential in-licensing. Qualifications
Required: Ph.D. in cardiovascular biology, pharmacology, molecular biology, or a related field. Required: 5+ years of industry experience in preclinical drug discovery and development, with a proven track record of advancing therapeutic programs. Required: Strong expertise in heart failure, including a deep understanding of its pathophysiology, preclinical models, and current therapeutic landscape. Skills
Preferred: Demonstrated leadership and people-management skills, with experience mentoring and developing scientific talent. Preferred: Ability to make data-driven decisions and find innovative solutions to overcome scientific and operational obstacles. Preferred: Strong project management skills, including the ability to manage complex research programs with multiple workstreams. Preferred: Excellent written and verbal communication skills, with the ability to present complex scientific data to diverse audiences. Preferred: Strong interpersonal skills for effective collaboration with internal teams, external partners, and vendors. Education
Ph.D. in cardiovascular biology, pharmacology, molecular biology, or a related field
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