Scientist/Sr. Scientist - Large Molecule Biology
Scorpion Therapeutics, New York, New York, us, 10261
Role Summary
As a scientist in the Large Molecule Biology group, you will join a large and dynamic group focused on executing experiments at the cutting edge of pharmaceutical sciences. You will execute experiments to support the various research programs for identified targets and oversee aspects of portfolio programs independently with minimal direct oversight. You will demonstrate laboratory expertise with biologic assays aimed at drug development (mAb, ADC and CD3 platforms) and assay development for specialized assays related to portfolio programs. You will be encouraged to develop your own ideas and contribute these to the broader group. You are expected to be a dynamic and motivated scientist who can drive their own experiments and research activities, while collaborating extensively with the rest of the organization to execute on various research programs. Responsibilities
Design and implement studies to identify, evaluate, and advance therapeutic candidates through the drug development pipeline. Demonstrate laboratory expertise with biologic assays aimed at drug development, specifically utilizing monoclonal antibodies (mAb), antibody-drug conjugates (ADC), and CD3 platforms. Manage the maintenance, culture, and passaging of multiple cell lines to support experimental objectives. Perform comprehensive functional assays and high-throughput screenings, including tumor cell signaling, internalization, cytotoxicity, effector function and cytokine release assays, to assess cellular responses. Conduct multi-parameter flow cytometry assays to determine binding interactions and accurately quantify receptor density across diverse cell populations. Conduct candidate evaluation in both in vitro (PK/PD, receptor occupancy, density, cytokine release), and ex vivo assays (tumor isolation, analysis of blood cells). Develop, validate, and perform bioanalytical assays—including ELISA—to precisely quantify proteins and antibodies relevant to experimental outcomes. Critically assess and monitor experimental procedures performed by third-party collaborators and vendors to ensure compliance with study protocols and quality standards. Work with the project leader and senior leader to design and execute assays for the development of the molecule. Present your work to internal teams and summarize findings in preclinical reports. Communicate results at project team meetings, be involved in the coordination and preparation of presentations. Discuss results with technical as well as non-technical personnel. Work in cross functional environments via extensive collaboration with other parts of the organization. Qualifications
Required: Bachelor\'s degree in biological sciences or related scientific field with 5+ years of experience, or Master’s in biological sciences or related scientific field with 2+ years of experience. Preferred: Experience with mammalian cell culture Preferred: Extensive expertise performing in vitro and ex vivo assays Preferred: Strong data analysis skills with attention to detail Preferred: Ability to design comprehensive experimental plans and carry out in a timely fashion Preferred: Deep expertise in cancer disease states (indications, mutational status, tumor cell drivers) Preferred: Demonstrated experience working collaboratively across various scientific disciplines to meet end goals of business Preferred: Excellent communication and interpersonal skills Preferred: Demonstrated ability to succeed in a fast-paced environment, working on multiple projects with constantly changing priorities and deadlines
#J-18808-Ljbffr
As a scientist in the Large Molecule Biology group, you will join a large and dynamic group focused on executing experiments at the cutting edge of pharmaceutical sciences. You will execute experiments to support the various research programs for identified targets and oversee aspects of portfolio programs independently with minimal direct oversight. You will demonstrate laboratory expertise with biologic assays aimed at drug development (mAb, ADC and CD3 platforms) and assay development for specialized assays related to portfolio programs. You will be encouraged to develop your own ideas and contribute these to the broader group. You are expected to be a dynamic and motivated scientist who can drive their own experiments and research activities, while collaborating extensively with the rest of the organization to execute on various research programs. Responsibilities
Design and implement studies to identify, evaluate, and advance therapeutic candidates through the drug development pipeline. Demonstrate laboratory expertise with biologic assays aimed at drug development, specifically utilizing monoclonal antibodies (mAb), antibody-drug conjugates (ADC), and CD3 platforms. Manage the maintenance, culture, and passaging of multiple cell lines to support experimental objectives. Perform comprehensive functional assays and high-throughput screenings, including tumor cell signaling, internalization, cytotoxicity, effector function and cytokine release assays, to assess cellular responses. Conduct multi-parameter flow cytometry assays to determine binding interactions and accurately quantify receptor density across diverse cell populations. Conduct candidate evaluation in both in vitro (PK/PD, receptor occupancy, density, cytokine release), and ex vivo assays (tumor isolation, analysis of blood cells). Develop, validate, and perform bioanalytical assays—including ELISA—to precisely quantify proteins and antibodies relevant to experimental outcomes. Critically assess and monitor experimental procedures performed by third-party collaborators and vendors to ensure compliance with study protocols and quality standards. Work with the project leader and senior leader to design and execute assays for the development of the molecule. Present your work to internal teams and summarize findings in preclinical reports. Communicate results at project team meetings, be involved in the coordination and preparation of presentations. Discuss results with technical as well as non-technical personnel. Work in cross functional environments via extensive collaboration with other parts of the organization. Qualifications
Required: Bachelor\'s degree in biological sciences or related scientific field with 5+ years of experience, or Master’s in biological sciences or related scientific field with 2+ years of experience. Preferred: Experience with mammalian cell culture Preferred: Extensive expertise performing in vitro and ex vivo assays Preferred: Strong data analysis skills with attention to detail Preferred: Ability to design comprehensive experimental plans and carry out in a timely fashion Preferred: Deep expertise in cancer disease states (indications, mutational status, tumor cell drivers) Preferred: Demonstrated experience working collaboratively across various scientific disciplines to meet end goals of business Preferred: Excellent communication and interpersonal skills Preferred: Demonstrated ability to succeed in a fast-paced environment, working on multiple projects with constantly changing priorities and deadlines
#J-18808-Ljbffr