Clinical Digital & AI Acceleration Portfolio Manager
Scorpion Therapeutics, Cambridge, Massachusetts, us, 02140
Role Summary
Clinical Digital & AI Acceleration Portfolio Manager — Location: Morristown, NJ / Cambridge, MA. A senior strategic partner to the Head of Clinical Digital & AI Acceleration, this role orchestrates the end-to-end transformation portfolio from strategy to value realization, ensuring initiatives are prioritized, integrated, governed, and scaled in line with CSO and enterprise objectives. Interfaces with executive sponsors, program leadership, finance, and business capability owners to deliver tangible outcomes and sustainable adoption, supported by robust portfolio performance intelligence. Responsibilities
Strategic Portfolio Alignment & Modernization
Continuously align portfolio components with Sanofi’s strategy and CSO priorities, ensuring a clear line of sight between transformation investments and business outcomes Shape and challenge the portfolio strategy by developing scenarios that support executive decision-making, trade-offs, and prioritization Identify cross-initiative synergies, reuse opportunities, and integration levers to avoid siloed digital initiatives Translate modernization ambitions (digital, data, AI) into executable, value-driven roadmaps Actively identify new modernization opportunities across clinical operations, informed by performance data, capability gaps, and emerging technologies
Portfolio Governance & Operating Model
Coordinate, evolve and professionalize the Initiative Portfolio Management Office (iPMO) as a strategic governance layer, not only a control mechanism Define and maintain governance standards covering value hypotheses, ROI tracking, adoption readiness, and scale-up criteria Coach and challenge program teams on business case quality, value articulation, and outcome-based delivery Ensure alignment with Digital, eDEV, and CSO innovation governance, including integration of externally incubated or “off-the-shelf” solutions Act as a modernization thought partner rather than a purely procedural PMO
Portfolio Performance & Value Management
Own the definition and consolidation of portfolio-level KPIs, including value realization, adoption, maturity, and transformation impact Monitor portfolio health using decision-grade performance intelligence (progress, risks, interdependencies, value delivery) Proactively identify risks, bottlenecks, and underperforming initiatives, and recommend corrective or reprioritization actions Ensure robust transition to business and establish and maintain a framework for visibility of transition to business and scale-up, tracking whether initiatives deliver value beyond pilot phases Produce executive-level insights and narratives linking digital transformation to tangible CSO outcomes Manage complex transformation program as needed
Financial Strategy & Value Realization
Partner with Finance and OPCM to drive disciplined investment management across the portfolio Ensure initiatives are supported by clear financial logic (ROI, cost avoidance, productivity gains, quality or cycle-time impact) Track financial performance across the lifecycle, from investment decision to realized value Support budget cycles and financial milestones with credible, evidence-based portfolio insights
Strategic Resource & Capability Alignment
Assess and consolidate portfolio-level resource needs, with a focus on critical capabilities rather than just capacity Optimize resource allocation across initiatives to maximize portfolio throughput and value Support vendor strategy, sourcing decisions, and contract governance in alignment with transformation priorities, and ensure up-to-date tracking of external resource allocation Identify capability gaps (digital, data, AI, change) and propose targeted upskilling or sourcing solutions Ensure coherent onboarding and enablement of teams across programs
Executive Communication & Stakeholder Engagement
Design and execute high-impact portfolio presentations, reports and communications for CSO leadership (SLT, deep dives, executive reviews, etc) Act as a trusted interlocutor for MPO leader and senior stakeholders, balancing competing priorities and perspectives Translate complex transformation topics into clear, outcome-oriented executive narratives Deliver concise, insight-driven monthly portfolio reports highlighting progress, deployment, value, risks, and decisions required
Qualifications
Minimum 7+ years in project and portfolio management, with demonstrated exposure to large-scale transformation or modernization programs Proven experience driving digital, data, or AI-enabled transformation in complex organizations Strong command of portfolio governance, value-based prioritization, and performance tracking Solid experience with business case development, ROI modeling, and financial steering Demonstrated ability to partner with senior leaders and influence without direct authority Experience in matrixed, global environments requiring orchestration across functions Skills
Strategic and systems thinker, able to connect initiatives into a coherent transformation narrative Strong analytical skills paired with business-oriented judgment Credible, calm leadership presence in executive settings Change/modernization-oriented mindset, comfortable challenging the status quo Excellent cross-cultural collaboration and communication skills Education
Bachelors required. Master\'s degree or PhD preferred. Experience in digital audit is a plus
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Clinical Digital & AI Acceleration Portfolio Manager — Location: Morristown, NJ / Cambridge, MA. A senior strategic partner to the Head of Clinical Digital & AI Acceleration, this role orchestrates the end-to-end transformation portfolio from strategy to value realization, ensuring initiatives are prioritized, integrated, governed, and scaled in line with CSO and enterprise objectives. Interfaces with executive sponsors, program leadership, finance, and business capability owners to deliver tangible outcomes and sustainable adoption, supported by robust portfolio performance intelligence. Responsibilities
Strategic Portfolio Alignment & Modernization
Continuously align portfolio components with Sanofi’s strategy and CSO priorities, ensuring a clear line of sight between transformation investments and business outcomes Shape and challenge the portfolio strategy by developing scenarios that support executive decision-making, trade-offs, and prioritization Identify cross-initiative synergies, reuse opportunities, and integration levers to avoid siloed digital initiatives Translate modernization ambitions (digital, data, AI) into executable, value-driven roadmaps Actively identify new modernization opportunities across clinical operations, informed by performance data, capability gaps, and emerging technologies
Portfolio Governance & Operating Model
Coordinate, evolve and professionalize the Initiative Portfolio Management Office (iPMO) as a strategic governance layer, not only a control mechanism Define and maintain governance standards covering value hypotheses, ROI tracking, adoption readiness, and scale-up criteria Coach and challenge program teams on business case quality, value articulation, and outcome-based delivery Ensure alignment with Digital, eDEV, and CSO innovation governance, including integration of externally incubated or “off-the-shelf” solutions Act as a modernization thought partner rather than a purely procedural PMO
Portfolio Performance & Value Management
Own the definition and consolidation of portfolio-level KPIs, including value realization, adoption, maturity, and transformation impact Monitor portfolio health using decision-grade performance intelligence (progress, risks, interdependencies, value delivery) Proactively identify risks, bottlenecks, and underperforming initiatives, and recommend corrective or reprioritization actions Ensure robust transition to business and establish and maintain a framework for visibility of transition to business and scale-up, tracking whether initiatives deliver value beyond pilot phases Produce executive-level insights and narratives linking digital transformation to tangible CSO outcomes Manage complex transformation program as needed
Financial Strategy & Value Realization
Partner with Finance and OPCM to drive disciplined investment management across the portfolio Ensure initiatives are supported by clear financial logic (ROI, cost avoidance, productivity gains, quality or cycle-time impact) Track financial performance across the lifecycle, from investment decision to realized value Support budget cycles and financial milestones with credible, evidence-based portfolio insights
Strategic Resource & Capability Alignment
Assess and consolidate portfolio-level resource needs, with a focus on critical capabilities rather than just capacity Optimize resource allocation across initiatives to maximize portfolio throughput and value Support vendor strategy, sourcing decisions, and contract governance in alignment with transformation priorities, and ensure up-to-date tracking of external resource allocation Identify capability gaps (digital, data, AI, change) and propose targeted upskilling or sourcing solutions Ensure coherent onboarding and enablement of teams across programs
Executive Communication & Stakeholder Engagement
Design and execute high-impact portfolio presentations, reports and communications for CSO leadership (SLT, deep dives, executive reviews, etc) Act as a trusted interlocutor for MPO leader and senior stakeholders, balancing competing priorities and perspectives Translate complex transformation topics into clear, outcome-oriented executive narratives Deliver concise, insight-driven monthly portfolio reports highlighting progress, deployment, value, risks, and decisions required
Qualifications
Minimum 7+ years in project and portfolio management, with demonstrated exposure to large-scale transformation or modernization programs Proven experience driving digital, data, or AI-enabled transformation in complex organizations Strong command of portfolio governance, value-based prioritization, and performance tracking Solid experience with business case development, ROI modeling, and financial steering Demonstrated ability to partner with senior leaders and influence without direct authority Experience in matrixed, global environments requiring orchestration across functions Skills
Strategic and systems thinker, able to connect initiatives into a coherent transformation narrative Strong analytical skills paired with business-oriented judgment Credible, calm leadership presence in executive settings Change/modernization-oriented mindset, comfortable challenging the status quo Excellent cross-cultural collaboration and communication skills Education
Bachelors required. Master\'s degree or PhD preferred. Experience in digital audit is a plus
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