Sr. Manager/Associate Director, Process Chemistry
Corvus Pharmaceuticals, Inc., San Francisco, California, United States
Department/Group: Chemistry
Location: South San Francisco, CA
Position Type: Full time Role and Responsibilities
* Independently design synthetic strategies and use those strategies to synthesize and characterize precursor compounds, starting materials, intermediates, reference compounds, and new chemical entities * Scale up and process development of small molecules across early through late-stage phases * Design and conduct control strategies for drug substance manufacturing including impurity identification and synthesis, and fate and purge experiments * Purify and characterize molecules with standard analytical techniques (e.g. HPLC, LCMS, NMR) * Collaborate with cross functional teams of product development, QA, analytical and formulations. * Work with contract organizations and support technology transfer * Perform research and/or development in collaboration with others in chemistry and biology; make detailed observations and analyze data. * Prepare batch records, technical reports, summaries, protocols and quantitative analyses * Write and review manuscripts for publication * Provide support in corporate research and development of patent applications * Develop strategies to ensure effective achievement of scientific objectives * Uses skills to contribute to development of company objectives and principles and to achieve goals in creative and effective ways * Exercises independent judgment in selecting methods, techniques and evaluation criteria for obtaining results
Qualifications and Education Requirements
* PhD in Chemistry plus 5+ years of related experience in pharmaceutical or biotechnology industry or equivalent. * Demonstrated expertise and hands‑on experience in synthetic organic chemistry process development and manufacturing. * Knowledge of regulatory (ICH, USP etc.) standards. * Experience working with CRO/CDMO partners for drug substance manufacturing. * Must possess expert knowledge of scientific principles and concepts. * A solid understanding of modern analytical techniques (NMR, HPLC, MS) * Excellent verbal and written communication skills and the ability to collaborate effectively within a multidisciplinary team
Preferred Skills
* Able to manage outside vendor collaborations * Flexibility and willingness to solve problems that fall outside of immediate area of expertise * Work independently in an interdisciplinary, fast‑paced, often changing environment. * Committed to the values of integrity, accountability, transparency, and drive.
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* Independently design synthetic strategies and use those strategies to synthesize and characterize precursor compounds, starting materials, intermediates, reference compounds, and new chemical entities * Scale up and process development of small molecules across early through late-stage phases * Design and conduct control strategies for drug substance manufacturing including impurity identification and synthesis, and fate and purge experiments * Purify and characterize molecules with standard analytical techniques (e.g. HPLC, LCMS, NMR) * Collaborate with cross functional teams of product development, QA, analytical and formulations. * Work with contract organizations and support technology transfer * Perform research and/or development in collaboration with others in chemistry and biology; make detailed observations and analyze data. * Prepare batch records, technical reports, summaries, protocols and quantitative analyses * Write and review manuscripts for publication * Provide support in corporate research and development of patent applications * Develop strategies to ensure effective achievement of scientific objectives * Uses skills to contribute to development of company objectives and principles and to achieve goals in creative and effective ways * Exercises independent judgment in selecting methods, techniques and evaluation criteria for obtaining results
Qualifications and Education Requirements
* PhD in Chemistry plus 5+ years of related experience in pharmaceutical or biotechnology industry or equivalent. * Demonstrated expertise and hands‑on experience in synthetic organic chemistry process development and manufacturing. * Knowledge of regulatory (ICH, USP etc.) standards. * Experience working with CRO/CDMO partners for drug substance manufacturing. * Must possess expert knowledge of scientific principles and concepts. * A solid understanding of modern analytical techniques (NMR, HPLC, MS) * Excellent verbal and written communication skills and the ability to collaborate effectively within a multidisciplinary team
Preferred Skills
* Able to manage outside vendor collaborations * Flexibility and willingness to solve problems that fall outside of immediate area of expertise * Work independently in an interdisciplinary, fast‑paced, often changing environment. * Committed to the values of integrity, accountability, transparency, and drive.
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