VP, Clinical Pharmacology

GondolaBio, San Francisco

GondolaBio is a clinical-stage biopharmaceutical company focused on developing breakthrough therapeutics for genetic diseases. GondolaBio is an independent sister company to BridgeBio, originally carved out in 2024 after securing $300M in private financing from external investors. GondolaBio aims to leverage cutting-edge biological research to discover, create, test, and deliver transformative medicines to treat patients who suffer from genetic diseases.

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Job Type: Full-time

VP, Clinical Pharmacology

Palo Alto, CA

About GondolaBio

Who You Are

You are an experienced clinical pharmacology leader with deep expertise in early clinical development and a strong track record of informing dose selection and development decisions for innovative therapies. You are comfortable setting strategy at the portfolio and program level while also rolling up your sleeves to execute in a small, fast-moving biotech environment, and you are energized by the opportunity to help build and shape clinical pharmacology approaches as the company and pipeline grow. You thrive at the intersection of pharmacology, translational science, and clinical development, and you bring a pragmatic, data-driven mindset to decision-making, particularly in rare and genetically defined diseases.

Key Responsibilities

Clinical pharmacology leadership & program ownership (preclinical ? FIH ? early PoC): Serve as the clinical pharmacology leader for multiple programs in GondolaBio’s pipeline, defining stage-appropriate PK/PD, exposure–response, and dose-selection strategies to support rapid, high-quality decisions through early proof of concept
FIH and early development strategy: Lead clinical pharmacology strategy for first-in-human and early Phase 1/2 studies, including starting dose rationale, dose escalation design, SAD/MAD strategy, and integration of nonclinical and translational data
PK/PD and translational integration: Design, interpret, and communicate PK/PD, biomarker, and exposure–response analyses to inform dose optimization and go/no-go decisions, in close partnership with Translational and Clinical Development teams
Model-informed drug development: Apply fit-for-purpose pharmacometric and modeling approaches to support early development decisions and regulatory interactions
Regulatory and cross-functional partnership: Partner across functions to support INDs, regulatory interactions, and integrated development plans; clearly communicate clinical pharmacology insights to senior leadership
External partner management: Oversee external pharmacometrics vendors, CROs, and consultants as needed to ensure timely, high-quality execution

Preferred Education & Experience

Ph.D., Pharm.D., M.D., or equivalent advanced degree in pharmacology, pharmaceutical sciences, or a related discipline
15+ years of experience in clinical pharmacology and/or pharmacometrics, including leadership at the program or portfolio level
Demonstrated record of supporting IND-stage programs through first-in-human and early clinical proof of concept
Strong expertise in dose selection, PK/PD integration, exposure–response, and early safety margin assessment
Experience working across multiple modalities (experience with oligonucleotides and small molecules is a plus)
Experience operating in small or mid-sized biotech environments where leaders are both strategic and hands‑on

Nice-to-Haves

Experience applying model-informed drug development in regulatory interactions
Familiarity with rare diseases or development programs with slow or indirect clinical endpoints
Prior experience serving as a senior clinical pharmacology voice with executive leadership or boards
Comfort making decisions with limited data while maintaining scientific rigor

No matter your role at GondolaBio, successful team members are

Patient Champions, who put patients first and uphold strict ethical standards
Entrepreneurial Operators, who drive toward practical solutions and have an ownership mindset
Truth Seekers, who are detailed, rational, and humble problem solvers
Individuals Who Inspire Excellence in themselves and those around them
High-quality executors, who execute against goals and milestones with quality, precision, and speed

What We Offer

Patient Days, where we are fortunate to hear directly from individuals living with the conditions we are seeking to impact throughout the year and learn how we can improve our efforts
A culture inspired by our values: put patients first, think independently, be radically transparent, every minute counts, and let the science speak
An unyielding commitment to always putting patients first.
A de-centralized model that enables our program teams to focus on advancing science and helping patients. Our affiliate structure is designed to eliminate bureaucracy and put decision-making power in the hands of those closest to the science
A place where you own the vision – both for your program and your own career path
A collaborative, fast-paced, data-driven environment where we inspire ourselves and each other to always perform at the top of our game
Access to learning and development resources to help you get in the best professional shape of your life
Robust and market-competitive compensation & benefits package (Base, Performance Bonus, Equity, health, welfare & retirement programs)
Flexible PTO
Rapid career advancement for strong performers
Potential ability to work on multiple GondolaBio Pharma programs across multiple therapeutic areas over time
Partnerships with leading institutions
Commitment to Diversity, Equity & Inclusion

The base pay range for this position is $302,000 to $360,000 per year. The actual compensation offered will be determined based on a number of job-related factors, including experience, skills, qualifications, and location. A bonus plan and equity will also be offered.

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