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Mansueto Ventures is home to two of the most iconic and vibrant brands in business publishing: Inc. and Fast Company. Every day, the content, awards, and events produced help entrepreneurs and innovators succeed by providing useful insights, sparking essential conversations, and offering much-needed inspiration.

Inc. is the voice of the American entrepreneur, inspiring and documenting the risk-takers and ultra-driven go-getters who represent the most dynamic force in the American economy.
Fast Company is the world’s leading business media brand, focusing on innovation in technology, leadership, and design to inspire readers to shape the future of business.

","New York, NY","coloredLogo","logoAttachment","thumbnail","thumbnailAttachment","hexCode","#080D0C","headline","Publisher of Inc. and Fast Company, empowering innovators and entrepreneurs.","/companies/mansueto-ventures-careers","hasJobSubmission","isSavedJob","similarJobs",[510,519,528,536,543],{"_429":428,"_434":511,"_452":453,"_444":445,"_243":512,"_441":513,"_427":428,"_111":437,"_431":194,"_433":194,"_454":453,"_442":514,"_425":515,"_455":456,"_430":115,"_476":516,"_460":517,"_478":437,"_479":514,"_481":482,"_483":518,"_485":486},["D",1770573600000],"Director, GMP Operational Quality page is loaded## Director, GMP Operational Qualitylocations:

Boston, MAtime type:

Full timeposted on:

Posted Todayjob requisition id:

REQ-27807**Job Description****General/Position Summary**The Director, Quality Assurance GMP Operations will oversee the GMP QA operations including batch disposition process across CDMOs in the US and Internationally.

Responsibilities include day-to day operational quality oversight for internal batch record review operations and QA manufacturing operations from clinical to commercial stage of product globally.The role will closely partner with operational stakeholders to lead/support the development and execution of quality & technical risk mitigation, execution of operational activities participation of governance committees associated with improvements to the disposition process.

A key expectation is the ability to closely collaborate and build relationships with internal and external stakeholders to drive compliance and continuous improvement activities.

The role may support on site internal manufacturing activities.The role is a 5 days on site role at Vertex in the Boston Seaport.**Key Duties & Responsibilities*** Establishment of quality oversight for internal quality and external CTO/CDMO operations for the batch disposition process, across development, launch and commercial manufacturing globally.* Proactively drives continuous improvements in processes, identifies and mitigates compliance gaps and drive culture of quality across all operational activities.* Manage the day-to-day timely release of finished product to ensure compliance with Regulatory and Vertex cGMP requirements.* Represent Quality and serve as a trusted partner for the disposition activities of drug product.* Lead and mentor other team members, support development of organizational capabilities and talent building.* Assure disposition activities across CDMOs are compliant and consistent.* Ensure adequate training to the Department personnel.* Manage the department resources with regards to budget and personnel.* Build strategic relationships with internal and external partners – CDMOs and CTOs within the Quality organization to ensure Quality issues are raised and addressed, as necessary.* Create and foster a culture of collaboration, development, and engagement for advancing quality outcomes and operational excellence.* Develop, establish, and implement Batch disposition operational Quality and Compliance metrics.* Act as the batch disposition subject matter expert (SME) in support of regulatory inspections and audits.* Establish/participate and lead GxP Cell & Gene Therapy Management Reviews to gain insights regarding efficiency and operational performance across the GXP operations, including identification of opportunities for improvement and associated actions.* Work closely with the cross- functional partners to prepare for and support Health Authority inspections, respond to information requests, adjudicate compliance discussions, and negotiate any required corrective actions.* Represent C&G Quality to lead/participate in complex projects and partner with key stakeholders for alignment in strategic and operational planning and delivery of business & financial priorities and goals.* May be required to support manufacturing on site activities.**Required Education Level*** Bachelor's degree or Master's degree or equivalent**Required Experience**10+ years of experience and 5+ years in a management/supervisory role, or the equivalent combination of education and experience in a regulated pharmaceutical environment**Required Knowledge/Skills*** In-depth global health regulatory agency knowledge and experience across GXP life cycle in Cell & Gene therapy and/or Biologics (EU GMPs, FDA 21CFR Part 1271, GxPs).* Broad and current knowledge of batch disposition industry trends and best practices in Cell/Gene therapies.* Preferred QA Operational experience for Autologous Cell Therapy Operations.* Broad technical knowledge in Cell technology, aseptic manufacturing technology, analytical assays, cell & genetic therapies/Biologics processing, fill/finish and testing.* Demonstrated strategic planning and execution skills required for operational effectiveness and compliance. Proven ability with Root Cause Analysis, data analytics, and other Operational Excellence experience, such as LEAN, DMAIC, Six Sigma.* Excellent communication skills and a proven track record Influencing/building/promoting a culture of Quality and Excellence.* Ability to apply risk management principles to decision making and operational priorities.* Critical Thinking and Problem Solving skills* Ability to closely collaborate and build relationships with internal and external stakeholders.**Other Requirements**

Up to 15% Travel may be required#LI-onsite**Pay Range:**$184,600 - $277,000**Disclosure Statement:**The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations.

From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.**Flex Designation:**On-Site Designated**Flex Eligibility Status:**In this **On-Site** designated role, you will work **five days per week on-site** with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.#LI-Onsite**Company Information**Vertex is a global biotechnology company that invests in scientific innovation.Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com\n#J-18808-Ljbffr\n","Director, GMP Operational Quality page is loaded## Director, GMP Operational Qualitylocations:

Boston, MAtime type:

Full timepost...","Boston, Massachusetts, us, 02298",["B","2490954604"],"10 days ago","/jobs/2490954604-director-gmp-operational-quality","/jobs?location=Boston%2C+Massachusetts%2C+us%2C+02298",{"_429":428,"_434":520,"_452":453,"_444":445,"_243":521,"_441":522,"_427":428,"_111":523,"_431":194,"_433":194,"_454":453,"_442":514,"_425":524,"_455":456,"_430":115,"_476":525,"_460":526,"_478":523,"_479":514,"_481":482,"_483":518,"_485":527},["D",1769853600000],"A biotechnology leader in Boston seeks an Associate Director of GMP Operational Quality to oversee quality compliance and provide leadership in the QC data review for gene therapy products. This role entails leading a quality team, ensuring compliance with GMP standards, and fostering cross-functional collaboration. The ideal candidate has extensive experience in quality assurance, a strong understanding of cGMP principles, and the ability to mentor and develop team members. Competitive salary and comprehensive benefits offered for this full-time position.\n#J-18808-Ljbffr\n","A biotechnology leader in Boston seeks an Associate Director of GMP Operational Quality to oversee quality compliance and provide leadership in the...","Associate Director, GMP Quality & Operations",["B","2373406317"],"18 days ago","/jobs/2373406317-associate-director-gmp-quality-operations","/jobs?keyword=Associate+Director%2C+GMP+Quality+%26+Operations",{"_429":428,"_434":529,"_452":453,"_444":445,"_243":530,"_441":531,"_427":428,"_111":532,"_431":194,"_433":194,"_454":453,"_442":514,"_425":533,"_455":456,"_430":115,"_476":516,"_460":534,"_478":532,"_479":514,"_481":482,"_483":518,"_485":535},["D",1770573600000],"A leading biotechnology firm in Boston is seeking a Director of GMP Operational Quality to oversee quality assurance operations for batch dispositions. This role entails managing GMP QA operations, ensuring compliance with regulatory standards, and fostering relationships with internal and external stakeholders to enhance operational efficiency. Candidates should have over a decade of experience in the pharmaceutical industry, including management experience and a strong background in Cell & Gene therapies. The position requires excellent communication skills and a proactive approach towards continuous improvement initiatives.\n#J-18808-Ljbffr\n","A leading biotechnology firm in Boston is seeking a Director of GMP Operational Quality to oversee quality assurance operations for batch dispositi...","Director, GMP Operations Quality & Batch Disposition",["B","2490964048"],"/jobs/2490964048-director-gmp-operations-quality-batch-disposition","/jobs?keyword=Director%2C+GMP+Operations+Quality+%26+Batch+Disposition",{"_429":428,"_434":537,"_452":453,"_444":445,"_243":438,"_441":438,"_427":428,"_111":538,"_431":432,"_433":194,"_454":453,"_442":443,"_425":539,"_455":456,"_430":115,"_476":540,"_460":541,"_478":538,"_479":443,"_481":482,"_483":484,"_485":542},["D",1771200000000],"Director, Channel Distribution Strategy",["B","2619536913"],"3 days ago","/jobs/2619536913-director-channel-distribution-strategy","/jobs?keyword=Director%2C+Channel+Distribution+Strategy",{"_429":428,"_434":544,"_452":453,"_444":445,"_243":438,"_441":438,"_427":428,"_111":545,"_431":432,"_433":194,"_454":453,"_442":443,"_425":546,"_455":456,"_430":115,"_476":547,"_460":548,"_478":545,"_479":443,"_481":482,"_483":484,"_485":549},["D",1771113600000],"Executive Medical Director, Global Medical Lead (Pain)",["B","2619535614"],"4 days ago","/jobs/2619535614-executive-medical-director-global-medical-lead-pain","/jobs?keyword=Executive+Medical+Director%2C+Global+Medical+Lead+%28Pain%29","actionData","errors"]