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Every career with Hearst Television is like a story. How it develops, where it takes you, the milestones you reach along the way – you’ve got a lot to look forward to as your unique career story unfolds. Hearst Television, a subsidiary of Hearst, owns and operates local television and radio stations serving nearly three dozen U.S. cities, reaching 24 million U.S. television households. Through its partnership with nearly all major networks, Hearst Television distributes national content across more than 120 video channels, including programming from ABC, NBC, CBS, CW, MY Net, MeTV, This TV, Estrella, and more. Hearst Television is recognized as one of the industry's premier companies. It has been honored with numerous awards for distinguished journalism and industry innovation, including the Walter Cronkite Award for political journalism, the national Edward R. Murrow Award, the DuPont-Columbia Award, and the George Foster Peabody Award.

","New York, NY","coloredLogo","logoAttachment","Hearst.png","thumbnail","thumbnailAttachment","Hearst_TV_Careers.png","hexCode","#2D75B9","headline","National multimedia company reaching 24 million households","https://production-rails-default.s3.amazonaws.com/uploads/company/logo_attachment/1072/Hearst.png","/companies/hearst-television","https://production-rails-default.s3.amazonaws.com/uploads/company/thumbnail_attachment/1072/Hearst_TV_Careers.png","hasJobSubmission","isSavedJob","similarJobs",[513,521,532,545,553],{"_429":428,"_434":514,"_452":453,"_444":445,"_243":438,"_441":438,"_427":428,"_111":515,"_431":432,"_433":194,"_454":453,"_442":443,"_425":516,"_455":456,"_430":115,"_476":517,"_460":518,"_478":519,"_480":443,"_482":483,"_484":485,"_486":520},["D",1771113600000],"Human Resources Business Partner Senior Director, Biopharmaceutical Sciences & M",["B","2619537654"],"4 days ago","/jobs/2619537654-human-resources-business-partner-senior-director-biopharmaceutical-sciences-m","Human Resources Business Partner Senior Director, Biopharmaceutic...","/jobs?keyword=Human+Resources+Business+Partner+Senior+Director%2C+Biopharmaceutic...",{"_429":428,"_434":522,"_452":453,"_444":445,"_243":523,"_441":524,"_427":428,"_111":525,"_431":194,"_433":194,"_454":453,"_442":526,"_425":527,"_455":456,"_430":115,"_476":528,"_460":529,"_478":525,"_480":526,"_482":483,"_484":530,"_486":531},["D",1769767200000],"Director, Engineering Operations (Cell and Genetic Therapies) page is loaded## Director, Engineering Operations (Cell and Genetic Therapies)locations:

Boston, MAtime type:

Full timeposted on:

Posted Todayjob requisition id:

REQ-27813**Job Description****Director, Engineering Operations (Cell and Genetic Therapies)****General Summary:**The Director, Engineering Operations – CGT is responsible for building and leading the Engineering Operations team within the broader Biopharmaceutical Sciences – Cell & Gene Therapy (CGT) Manufacturing and Process Engineering organization. Vertex is rapidly progressing a pipeline of exciting cell and genetic therapy and biologics programs requiring development of sustainable and scalable clinical and commercial manufacturing capabilities across multiple sites in the Boston area. The Director is accountable for the full spectrum of engineering value-added services provided for site-based internal CGT manufacturing operations. Areas of responsibility include, but are not limited to, Process/Project Engineering, Manufacturing Technical Operations, Digital Systems and Validation, in direct support of CGT Internal Manufacturing Operations. The Engineering Operations team is also responsible for collaborating with key CGT Leadership to compile, secure funding, track and deliver capital investments for innovative technologies and expanded capacity to meet the development and commercialization program timelines. The Director has impact and interaction across multiple Vertex departments and will represent the broader team in several senior level forums. The Director is responsible for delivering engineering support for clinical programs and commercial operations for Cell and Gene based modalities as assigned to support the product portfolio.This role will report to the VP CGT Manufacturing and Process Engineering or designee and is an On-Site position. The position is based at Vertex’s Leiden Center 1 in Boston, MA, however, will also have responsibilities for other locations in the Boston metro area.**Key Responsibilities:*** **Define a sustainable and scalable strategy for engineering support of internal GMP manufacturing facilities in alignment with Vertex’s corporate strategy**. This strategy includes defining the key elements of collaboration with the Intermediate and Final Product manufacturing leaders, Regulatory, Quality Assurance, Finance, Corporate Facilities and Engineering, DTE and Commercial Supply Chain team to ensure seamless transitions to Commercial operations at the Boston facilities while continuing to provide clinical supply.* **Leadership of the Validation Team**. This team is responsible for compliance with US and ROW regulatory requirements as they apply to cGMP CGT Manufacturing Facility and Equipment Qualifications including Site and Project related Validation Master Plans, Clean Room Environment PQ and Clean Utility PQ, and the Periodic Assessment and Requalification program as well as initial and periodic, Aseptic Process Simulation (APS).* **Leadership of the Process/Project Engineering Team.** This includes assessing current state to identify and fill skill gaps by building a team that can actively support on-going CGT manufacturing operations with continuous improvement opportunities, troubleshooting in real-time issues that disrupt the manufacturing process and implementing alarm management and process controls related digital systems to ensure compliant operations. Drive execution of the Capital Plan and Operational Readiness within schedule constraints while maintaining budget.* **Leadership of the Manufacturing Technical Operations Team,** maintain Center of Excellence approach to managing QMS related records and facilitate investigations, root cause analysis, CAPA development, change control, risk management, associated trackers, KPI’s and Metrics to facilitate the CGT Culture of Compliance.* **Leadership of the Digital Systems Team.** This team is responsible for Driving Initial Implementation and Lifecycle management of Digital Systems Road Map for Cell Manufacturing including Oracle Material Operations Modules for Inventory control and Direct Procurement, RTMS for production capacity modeling and scheduling, Rapid Response for Planning and Procurement, Distributed Control System, LIMs and MES.* **In collaboration with key stakeholders and leadership support the integrated operations launch plan for the CGT pipeline programs.** This strategy includes establishing and maintaining an audit ready state of the Boston Manufacturing CGT Sites across full spectrum of areas of accountability to efficiently and effectively achieve approval to produce commercial CGT intermediate and final drug products. The Director is responsible for leading the team through launch readiness and hyper care, including making risk-based decisions to enable program success, while supporting the ongoing concurrent Clinical Manufacturing and Process Development activities.* **Drive excellence in end-to-end operations through identification and management of key metrics and KPI’s.** Drive operational efficiency, flawless execution, and continuous improvement across the supply chain to deliver a best-in-class supply chain.* **Champion the culture of quality and ensure that all activities and documentation comply with global regulatory requirements**. Understand and implement processes and controls that align with evolving Health Authority regulatory expectations.**Minimal Requirements:*** 10-15 years progressive experience in GMP Manufacturing/Process Engineering leadership roles in the Biopharmaceutical industry. Experience with Cell Therapy, Genetic Therapy and Biological products and technologies is preferred.* Bachelor Degree in an Engineering discipline with an advanced degree preferred.* Minimum 10 years’ experience with GMP biopharmaceutical manufacturing environment including experience in commercial setting.* Expert level proficiency with Manufacturing Related Process Engineering and Project Engineering with Advance level of proficiency with Manufacturing systems including eBR, DCS/SCADA, Pi, ERP, QMS with system integrations and paperless execution strategies.* Expert level proficiency with Investigations, Root Cause Analysis, CAPA, Change Control, Risk Assessment/Mitigation.* Advanced level proficiency in Aseptic Operations including Process Simulation, Personnel Qualification, Facility Cleaning and GMP Training and associated Regulatory Requirements for Commercial Drug Product Manufacturing.* Experience in building and managing a high performing team supporting complex biologics-based manufacturing operations.* The candidate is expected to be a thought leader in engineering or related fields and have a proven ability to innovate and implement practical, compliant solutions.* A proven ability to work seamlessly across teams and develop partnerships with peers is critical to success in this role.* Understanding of the principles and regulations associated with manufacturing operations for biological, cellular, and genetic therapies.* A results-oriented leader with a sense of urgency to deliver quality results in a highly ethical and professional manner.* Motivational leadership of a cohesive high-performing team of greater than twenty members within a global, matrixed environment; the ability to articulate vision and successfully drive execution.* Excellent communication and interpersonal skills with the ability to communicate complex issues and solutions enterprise-wide.* An excellent team player who can build and sustain respect and trust at all levels of the organization.* Ability to anticipate adverse scenarios and provide contingency plans to address them.* Sound judgment and business acumen with personal versatility and flexibility as the business and team evolve.**Pay Range:**$187,200 - $280,800**Disclosure Statement:**The range provided\n#J-18808-Ljbffr\n","Director, Engineering Operations (Cell and Genetic Therapies) page is loaded## Director, Engineering Operations (Cell and Genetic Therapies)locatio...","Director, Engineering Operations (Cell and Genetic Therapies)","Boston, Massachusetts, us, 02298",["B","2359319666"],"19 days ago","/jobs/2359319666-director-engineering-operations-cell-and-genetic-therapies","/jobs?location=Boston%2C+Massachusetts%2C+us%2C+02298","/jobs?keyword=Director%2C+Engineering+Operations+%28Cell+and+Genetic+Therapies%29",{"_429":428,"_434":533,"_452":453,"_444":534,"_243":535,"_441":536,"_427":428,"_111":537,"_431":194,"_433":194,"_454":453,"_442":467,"_425":538,"_455":539,"_430":115,"_476":540,"_460":541,"_478":537,"_480":467,"_482":542,"_484":543,"_486":544},["D",1769150543000],"Vertex Pharmaceuticals Incorporated","

Job Description

Biologics, Cell and Gene Therapy is a rapidly growing part of Vertex Pharmaceuticals where research, development, and clinical manufacturing are highly integrated together at our new R&D site in Boston Seaport.

General Summary

Vertex is seeking a highly skilled technical leader to join our Process Development / Engineering team to lead the development and manufacturing of biologics drug products for our growing pipeline. The Vertex Process Development team offers a dynamic, fast-paced, and highly collaborative environment with a tremendous impact on our programs and for our patients. Our team focuses on bringing together the best process design, scale‑up and cutting‑edge manufacturing technologies to enable the successful implementation of Biologics, Cell and Genetic therapeutics.

The successful candidate will lead the development and manufacturing of biologics drug products. The responsibilities include formulation development, primary container development, fill‑finish process development, technology transfer of manufacturing processes to CDMOs, and process validation to support our clinical pipeline toward commercialization. This is a highly cross‑functional role that will work closely with drug substance development, analytical development, device development and supply chain management in CMC teams to drive technical and strategic decision‑making.

Key Duties and Responsibilities

Lead phase‑appropriate strategies for drug product development, process transfer, scale‑up and process characterization to support commercial readiness.
Set‑up and oversee external capabilities for developability assessment and formulation screening for high‑concentration biologics, ADCs and other biologics modalities.
Define and develop robust fill‑finish manufacturing processes for liquid and lyophilized drug products in vials, pre‑filled syringes and other novel primary packaging.
Oversee drug product technology transfer, process development and GMP manufacturing operations at CDMOs.
Define and develop clinical dose preparation and administration strategies for drug products for multiple indications. Collaborate with clinical and supply chain teams to prepare clinical study documentation.
Collaborate with the device development team to develop combination product presentations such as pre‑filled syringes, autoinjectors and advance delivery technologies.
Define and implement drug substance and drug product stability and shelf‑life assessment approaches.
Develop and manage project timelines, resource allocation, and budget for drug product programs.
Manage deviations and OOT/OOS investigations at the CDMOs in collaboration with Quality, External Manufacturing and Regulatory team.
Define and implement control strategies, validation protocols, and process characterization studies in accordance with Quality by Design (QbD) principles.
Author and review regulatory submissions: IND/IMPD, briefing books and BLA.
Serve as a subject matter expert in regulatory agency interactions, audits, and inspections.
Identify and implement innovative technologies and best practices to improve process robustness, efficiency, and compliance.
Potential in the future to build and manage a team of scientists and engineers to deliver high‑quality, scalable, and compliant drug product processes from early development through commercialization.
Expected travel: 10-20% (domestic and international).

Required Education

PhD in Chemical Engineering, Biochemical Engineering, Pharmaceutical Sciences or related discipline with commensurate years of education and experience.
Minimum of 11 years of experience in drug product development and manufacturing. MS with 14+ years of relevant experience may be considered.

Required Experience and Skills

Expertise in formulation development of recombinant proteins including antibodies, ADCs, and fusion proteins.
Expertise in developing stable, high concentration liquid formulation and dosage forms for biologics and applying cutting‑edge technologies to develop stable drug products.
Deep knowledge in developing aseptic fill‑finish manufacturing process for biologics drug products in vials, pre‑filled syringe and cartridge presentation.
Experience successfully delivering development programs with CDMOs.
Proven track record of advancing drug products from INDs into late phase development and commercialization.
Experience with process characterization, process control strategy establishment and process performance qualification for commercialization using Quality by Design (QbD) principles.
Extensive knowledge of cGMPs and regulatory guidelines for biologics and can serve as an internal thought‑leader to drive decision making.
Strong data analysis and scientific communication skills, including experience with regulatory documentation, with the ability to influence and drive decision making at multiple levels within a CMC organization.
Demonstrated leadership with experience managing technical staff (internal or external) and cross‑functional collaborations.

Pay Range

$195,500 - $293,200

Disclosure Statement

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market‑leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week‑long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation

On‑Site Designated

Flex Eligibility Status

In this On‑Site designated role, you will work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

Job Description

Biologics, Cell and Gene Therapy is a rapidly growing part of Vertex Pharmaceuticals where research, development, a...","Director, Drug Product Process Development - Biologics",["B","1981933971"],"Work at Vertex Pharmaceuticals Incorporated","26 days ago","/jobs/1981933971-director-drug-product-process-development-biologics","/jobs?keyword=Vertex+Pharmaceuticals+Incorporated","/jobs?location=Boston","/jobs?keyword=Director%2C+Drug+Product+Process+Development+-+Biologics",{"_429":428,"_434":546,"_452":453,"_444":534,"_243":547,"_441":548,"_427":428,"_111":549,"_431":194,"_433":194,"_454":453,"_442":467,"_425":550,"_455":539,"_430":115,"_476":477,"_460":551,"_478":549,"_480":467,"_482":542,"_484":543,"_486":552},["D",1771362390000],"

Job Description

Vertex is seeking a highly skilled technical leader to join our Process Development / Engineering team to lead the design, development, optimization, and scale-up of downstream processes to produce therapeutic biologics. This leadership role is critical in advancing our pipeline of innovative biologics from early development through to commercial readiness. Our team focuses on bringing together the best process design, scale-up and cutting-edge manufacturing technologies to enable the successful implementation of Biologics, Cell and Genetic therapeutics.

General Summary

Key Duties and Responsibilities

Lead phase-appropriate strategies for downstream process development, process transfer, scale-up and process characterization to support commercial readiness.
Set-up and oversee external capabilities for downstream process development of monoclonal antibodies, ADCs and other biologics modalities. This includes directing activities such as capture chromatography, polishing steps, and viral clearance.
Develop and manage project timelines, resource allocation, and budget for downstream programs.
Oversee drug substance technology transfer, process development and GMP manufacturing operations at CDMOs, in close partnership with upstream development, analytical development, formulation, external manufacturing and quality assurance.
Manage deviations and OOT/OOS investigations at the CDMOs in collaboration with Quality, External Manufacturing and Regulatory team.
Define and implement control strategies, validation protocols, and process characterization studies in accordance with Quality by Design (QbD) principles.
Author and review regulatory submissions: IND/IMPD, briefing books and BLA.
Serve as a subject matter expert in regulatory agency interactions, audits, and inspections.
Develop and implement strategies for improved purification efficiency, robustness, and cost-effectiveness, including evaluation of new technologies and materials.
Potential in the future to build and manage a team of scientists and engineers to deliver high-quality, scalable, and compliant downstream drug substance processes from early development through commercialization.
Expected travel: 10-20% (domestic and international)

Required Education

PhD in Chemical Engineering, Biochemical Engineering, Pharmaceutical Sciences or related discipline with commensurate years of education and experience.
Minimum of 11 years of experience in drug substance development and manufacturing. MS with 14+ years of relevant experience may be considered.

Required Experience and Skills

Demonstrated leadership in downstream process development for recombinant proteins including antibodies, ADCs, and fusion proteins.
Hands‑on experience with chromatography systems (AKTA, Unicorn), UF/DF systems, and viral clearance strategies. Familiarity with continuous purification technologies and single‑use systems is strongly preferred.
Experience successfully delivering development programs with CDMOs.
Strong track record of scaling processes from lab to pilot and GMP/commercial production.
Proven track record of advancing drug substance from INDs into late phase development and commercialization.
Experience with process characterization, process control strategy establishment and process performance qualification for commercialization using Quality by Design (QbD) principles.
Extensive knowledge of cGMPs and regulatory guidelines for biologics and can serve as an internal thought‑leader to drive decision making.
Strong data analysis and scientific communication skills, including experience with regulatory documentation, with the ability to influence and drive decision making at multiple levels within a CMC organization.
Demonstrated leadership with experience managing technical staff (internal or external) and cross‑functional collaborations.

Pay Range

$195,500 - $293,200

Disclosure Statement

Flex Designation

On‑Site Designated>

Flex Eligibility Status

In this On‑Site designated role, you will work five days per week on‑site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Onsite

Job Description

Vertex is seeking a highly skilled technical leader to join our Process Development / Engineering team to lead the ...","Director, Downstream Process Development - Biologics",["B","2610034438"],"/jobs/2610034438-director-downstream-process-development-biologics","/jobs?keyword=Director%2C+Downstream+Process+Development+-+Biologics",{"_429":428,"_434":554,"_452":453,"_444":555,"_243":556,"_441":557,"_427":428,"_111":558,"_431":432,"_433":194,"_454":453,"_442":443,"_425":559,"_455":560,"_430":115,"_476":517,"_460":561,"_478":558,"_480":443,"_482":562,"_484":485,"_486":563},["D",1771113600000],"Tango Therapeutics","

Director, Human Resources Business Partner

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.

Reporting to the CHRO, the Director, Human Resources Business Partner (HRBP) provides HR leadership and consultation to client groups within one or multiple functions, including Clinical Development, Regulatory, and other key late-stage clinical areas. The HRBP is a trusted advisor to leaders, providing expert HR advice and advanced solutions that enable the achievement of business strategies by leveraging a significant understanding of the operating environment. This role drives talent management and helps architect and manage organizational change. The role is responsible for the delivery of HR programs and services such as talent/career development, manager coaching and consultation, employee relations, and performance management.

Your role

Provides strategic HR leadership and expert guidance to assigned client groups, along with consultation and delivery of HR programs and services to achieve key business objectives
Leverages previous experience and data to provide critical insights into business and talent trends that inform the overall business and HR priorities. Provides insights in a simple, creative, and relevant way that challenges current thinking, informs business decisions, and shows how decisions impact business outcomes
Proactively defines, builds, and implements value-added HR strategies and solutions
Advises functional leaders in solving complex issues related to organization design, development, and change leadership
Establishes strategies and tactics to enable the business to attract, develop, and retain high-quality talent at all levels to support the growth objectives, opportunities, and strategies of the business
Leads the strategic workforce planning efforts to ensure the people and talent strategy is in alignment with the organization's long range strategic plan (identification of long-term capability needs, talent acquisition and succession planning)
Builds strong partnerships within the HR team to enhance the function's effectiveness in providing solutions to key business needs and to roll out corporate-wide programs that enhance the overall employee experience and support growth and success of overall business strategy
Works with clients to implement and manage key HR processes, such as year-end performance management (performance assessment, calibration, and compensation planning)
Partners with Talent Acquisition (TA) to ensure TA strategy is in place to deliver on key hires and growth plans

What you bring

Education and Experience: Undergraduate degree in human resources or related, relevant discipline
Typically requires 10 years of experience or the equivalent combination of education and experience

Knowledge and Skills: Experience developing and implementing HR strategies
Track record of developing strategic workforce plans, from conception to implementation
Highly experienced in talent management, succession planning, and career growth and development
Strong experience managing and/or leading culture and change management or organizational effectiveness initiatives
Experience and expert understanding of management development, employee relations, data and analytics

Traits and Qualities: Ability to influence positively including in situations without direct authority
Ability to work independently and collaboratively, in a matrix team environment consisting of internal and external team members
Analytical thinker with excellent problem-solving skills and the ability to adapt to changing priorities and deadlines
Excellent planning, organization and time management skills including the ability to support, prioritize, and multi-task
Highly collaborative team player who fosters open communication and develops important relationships with key stakeholders
Outstanding interpersonal and communication abilities with a high degree of emotional intelligence
Possess the ability, business maturity and interpersonal savvy to be proactive and establish credibility with all employees across the Company
Have proven communication skills, both written and verbal, and the ability to present information clearly to a variety of audiences
Able to learn quickly and take a project from idea to execution (strategy to operational) quickly and independently
Thrives in high energy and fast paced organization with ongoing simultaneous initiatives
Builds consensus and alignment and persuades others to take action

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Salary range $163,200 - $244,800 USD

","

Director, Human Resources Business Partner

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets an...","Director, Human Resources Business Partner",["B","1998267505"],"Work at Tango Therapeutics","/jobs/1998267505-director-human-resources-business-partner","/jobs?keyword=Tango+Therapeutics","/jobs?keyword=Director%2C+Human+Resources+Business+Partner","actionData","errors"]

Job Description

General Summary

Key Duties and Responsibilities

Required Education

Required Experience and Skills

Pay Range

Disclosure Statement

Flex Designation

Flex Eligibility Status

Company Information

Job Description

Job Description

General Summary

Key Duties and Responsibilities

Required Education

Required Experience and Skills

Pay Range

Disclosure Statement

Flex Designation

Flex Eligibility Status

Company Information

Job Description

Director, Human Resources Business Partner

Director, Human Resources Business Partner