Scientific Director, Oligonucleotide Chemistry Research
Scorpion Therapeutics, Rancho Santa Fe, California, United States
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Role Summary The Scientific Director, Oligonucleotide Chemistry Research is a highly motivated and accomplished chemist/biochemist with a proven track record of delivering multiple oligonucleotide-based candidate molecules to the clinical development candidate stage. The ideal candidate will be a leader in the field of siRNA chemistry and design, and a people leader with a passion for mentoring and empowering their team. The candidate will lead projects in a fast-paced environment and play a key role in providing strategic direction for next-generation oligonucleotide-based therapeutics for our three therapeutic areas of interest: neurology, neuroendocrinology, and neuroimmunology.
Responsibilities
Set scientific direction for siRNA platform chemistry and direct internal and external chemists tasked with designing, synthesizing and characterizing novel oligonucleotides, associated libraries, and oligonucleotide-based bioconjugates for eventual development candidate nomination
Provide strategic direction, oversight and input for multiple siRNA-based projects including the chemistry strategy, bioconjugation strategy where applicable, and overall goals and timelines
Help set scientific direction for use of siRNA, ASO, and associated oligonucleotide-based modalities
Participate in and/or lead multiple discovery projects and project teams
Drive the development and incorporation of novel technologies, methods and oligonucleotide modifications for optimal stability, potency and selectivity
Collaborate seamlessly with the adjacent Bioconjugation team as well as the Peptide, Antibody and Small Molecule teams to achieve maximal synergy between the teams and platforms
Collaborate closely with the broader research team by communicating results, sharing insights, making plans, and setting goals in an open and collaborative way to enable project success
Anticipates potential issues and provides contingencies and resolutions to continuously improve that process
Monitors and evaluates completion of work and projects of their direct reports to ensure a high-functioning team, and takes necessary action as needed
Aid in the evaluation of external partnering opportunities
Performs other duties as assigned
Qualifications
PhD (preferred) in chemistry or related field and 10+ years of experience in the pharmaceutical industry and prior managerial / functional management experience
MS/MA degree and 13+ years of similar experience as noted above, OR
BS/BA degree and 15+ years of similar experience
Demonstrated scientific excellence in oligonucleotide/siRNA chemistry or related research, as evidenced by significant patents and/or publications in the field
Excellent leadership skills and ability, typically leads multi-level teams and/or indirect teams
Demonstrated delivery of multiple clinical candidate siRNA-based molecules
Expert understanding of the drug discovery process
Thorough understanding of developability and associated assays
Experience and knowledge in protein bioconjugation and/or targeted delivery technologies is strongly preferred
Overall strong work ethic and willingness to engage in projects across therapeutic areas
Recognized as an internal thought leader with extensive technical and business expertise within a strategic organization
Applies in-depth knowledge of own function, business / commercial / scientific expertise to solve critical issues successfully and innovatively
Evaluates key business / scientific challenges and completes complex, ambiguous initiatives having cross-functional impact
Sees broader picture, impact on multiple programs, teams and/or departments
Ability to effectively interact with multiple functions across the organization, and effectively communicate results and strategies to staff and company executives
Strong attention to detail; excellent written, oral and interpersonal communication skills
Excellent problem solving and analytical thinking skills
Education
PhD preferred in chemistry or related field; or MS/MA with 13+ years of experience; or BS/BA with 15+ years of experience
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Role Summary The Scientific Director, Oligonucleotide Chemistry Research is a highly motivated and accomplished chemist/biochemist with a proven track record of delivering multiple oligonucleotide-based candidate molecules to the clinical development candidate stage. The ideal candidate will be a leader in the field of siRNA chemistry and design, and a people leader with a passion for mentoring and empowering their team. The candidate will lead projects in a fast-paced environment and play a key role in providing strategic direction for next-generation oligonucleotide-based therapeutics for our three therapeutic areas of interest: neurology, neuroendocrinology, and neuroimmunology.
Responsibilities
Set scientific direction for siRNA platform chemistry and direct internal and external chemists tasked with designing, synthesizing and characterizing novel oligonucleotides, associated libraries, and oligonucleotide-based bioconjugates for eventual development candidate nomination
Provide strategic direction, oversight and input for multiple siRNA-based projects including the chemistry strategy, bioconjugation strategy where applicable, and overall goals and timelines
Help set scientific direction for use of siRNA, ASO, and associated oligonucleotide-based modalities
Participate in and/or lead multiple discovery projects and project teams
Drive the development and incorporation of novel technologies, methods and oligonucleotide modifications for optimal stability, potency and selectivity
Collaborate seamlessly with the adjacent Bioconjugation team as well as the Peptide, Antibody and Small Molecule teams to achieve maximal synergy between the teams and platforms
Collaborate closely with the broader research team by communicating results, sharing insights, making plans, and setting goals in an open and collaborative way to enable project success
Anticipates potential issues and provides contingencies and resolutions to continuously improve that process
Monitors and evaluates completion of work and projects of their direct reports to ensure a high-functioning team, and takes necessary action as needed
Aid in the evaluation of external partnering opportunities
Performs other duties as assigned
Qualifications
PhD (preferred) in chemistry or related field and 10+ years of experience in the pharmaceutical industry and prior managerial / functional management experience
MS/MA degree and 13+ years of similar experience as noted above, OR
BS/BA degree and 15+ years of similar experience
Demonstrated scientific excellence in oligonucleotide/siRNA chemistry or related research, as evidenced by significant patents and/or publications in the field
Excellent leadership skills and ability, typically leads multi-level teams and/or indirect teams
Demonstrated delivery of multiple clinical candidate siRNA-based molecules
Expert understanding of the drug discovery process
Thorough understanding of developability and associated assays
Experience and knowledge in protein bioconjugation and/or targeted delivery technologies is strongly preferred
Overall strong work ethic and willingness to engage in projects across therapeutic areas
Recognized as an internal thought leader with extensive technical and business expertise within a strategic organization
Applies in-depth knowledge of own function, business / commercial / scientific expertise to solve critical issues successfully and innovatively
Evaluates key business / scientific challenges and completes complex, ambiguous initiatives having cross-functional impact
Sees broader picture, impact on multiple programs, teams and/or departments
Ability to effectively interact with multiple functions across the organization, and effectively communicate results and strategies to staff and company executives
Strong attention to detail; excellent written, oral and interpersonal communication skills
Excellent problem solving and analytical thinking skills
Education
PhD preferred in chemistry or related field; or MS/MA with 13+ years of experience; or BS/BA with 15+ years of experience
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