Site Name & Posted Date
USA - Massachusetts - Cambridge Posted Date: Feb 24 2026 Job Title
Scientific Leader In Vivo Pharmacology - Oligonucleotide Discovery Location
200 Cambridge Park Drive, Cambridge, MA Position Overview
We are seeking a highly motivated Scientific Leader to join the In Vivo Pharmacology team at GSK. The individual will be involved in designing and executing PK/PD studies supporting the advancement of oligonucleotide therapeutics. The successful candidate will bring deep hands‑on expertise in rodent and non‑human primate (NHP) models, strong experimental design skills, and direct experience with molecular assays, including qPCR. The individual will be a highly organized professional who can manage multiple projects simultaneously while maintaining quality. This role demands equal parts of operational excellence and scientific expertise, and will be a key contributor to preclinical development programs. Key Responsibilities
Design, lead, and execute in vivo studies in rodent and non‑human primate (NHP) models to support target validation, lead optimization, and candidate selection. Manage and oversee in vivo studies conducted internally or with external CROs, including scope definition, protocol review, operational activities, data quality oversight, and scientific interpretation and communication of results. Ensure timely scheduling, execution, and delivery of in vivo studies in alignment with project plans, milestones, and decision points; proactively identify risks and implement mitigation strategies. Apply deep subject‑matter expertise in biology, pharmacology, and delivery for evaluating oligonucleotide therapeutics or related modalities in preclinical models. Analyze, interpret data and communicate results clearly and objectively to key internal stakeholders. Collaborate cross‑functionally with DMPK, non‑clinical safety, chemistry, in vitro and project teams to ensure robust study design and data generation. Experience with hands‑on molecular biology assays, with a strong emphasis on qPCR, including assay development, optimization, execution, and data analysis from in vivo samples is strongly preferred. Basic Qualifications
PhD in Pharmacology, Biology, Biochemistry, or a related scientific discipline, with minimum 4+ years of relevant industry experience. Three or more years of experience in in vivo PK/PD study design and execution in rodent and non‑human primate models. Two or more years of experience working with oligonucleotide therapeutics in a preclinical setting is required. Three or more years of experience independently designing studies, troubleshooting complex experimental challenges, and delivering high‑quality data. Three or more years of experience conducting in vivo techniques, including dosing, tissue collection, and related procedures, is required. Preferred Qualifications
Experience working in a pharmaceutical or biotechnology research environment. Experience in working and managing CROs. Hands‑on experience with qPCR assays, including assay development, optimization, and data analysis of in vivo samples. Track record of delivering data for regulatory submissions or IND‑enabling packages. Excellent written and verbal communication skills, with the ability to present data clearly to multidisciplinary teams. Compensation & Benefits
If you are based in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary for new hires ranges $140,250 to $233,750. This position also offers an annual bonus and eligibility to participate in a share‑based long‑term incentive program. Benefits include health care and other insurance benefits for employee and family, retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave. Please visit
GSK US Benefits Summary
to learn more about the comprehensive benefits program. Why GSK?
Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company with a purpose to unite science, technology and talent to move ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, focus on four therapeutic areas, and create an environment where people can thrive. Important Notice to Employment Businesses/Agencies
GSK does not accept referrals from employment businesses and/or agencies for vacancies posted on this site. All employment businesses/agencies must obtain prior written authorization from GSK’s commercial and general procurement/human resources department before referring candidates. GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law. Contact
For adjustments to our process to demonstrate strengths and capabilities, contact
HR.AmericasSC-CS@gsk.com
where you can also request a call. For general inquiries not related to adjustments, please see the Recruitment FAQ guide:
link .
#J-18808-Ljbffr
USA - Massachusetts - Cambridge Posted Date: Feb 24 2026 Job Title
Scientific Leader In Vivo Pharmacology - Oligonucleotide Discovery Location
200 Cambridge Park Drive, Cambridge, MA Position Overview
We are seeking a highly motivated Scientific Leader to join the In Vivo Pharmacology team at GSK. The individual will be involved in designing and executing PK/PD studies supporting the advancement of oligonucleotide therapeutics. The successful candidate will bring deep hands‑on expertise in rodent and non‑human primate (NHP) models, strong experimental design skills, and direct experience with molecular assays, including qPCR. The individual will be a highly organized professional who can manage multiple projects simultaneously while maintaining quality. This role demands equal parts of operational excellence and scientific expertise, and will be a key contributor to preclinical development programs. Key Responsibilities
Design, lead, and execute in vivo studies in rodent and non‑human primate (NHP) models to support target validation, lead optimization, and candidate selection. Manage and oversee in vivo studies conducted internally or with external CROs, including scope definition, protocol review, operational activities, data quality oversight, and scientific interpretation and communication of results. Ensure timely scheduling, execution, and delivery of in vivo studies in alignment with project plans, milestones, and decision points; proactively identify risks and implement mitigation strategies. Apply deep subject‑matter expertise in biology, pharmacology, and delivery for evaluating oligonucleotide therapeutics or related modalities in preclinical models. Analyze, interpret data and communicate results clearly and objectively to key internal stakeholders. Collaborate cross‑functionally with DMPK, non‑clinical safety, chemistry, in vitro and project teams to ensure robust study design and data generation. Experience with hands‑on molecular biology assays, with a strong emphasis on qPCR, including assay development, optimization, execution, and data analysis from in vivo samples is strongly preferred. Basic Qualifications
PhD in Pharmacology, Biology, Biochemistry, or a related scientific discipline, with minimum 4+ years of relevant industry experience. Three or more years of experience in in vivo PK/PD study design and execution in rodent and non‑human primate models. Two or more years of experience working with oligonucleotide therapeutics in a preclinical setting is required. Three or more years of experience independently designing studies, troubleshooting complex experimental challenges, and delivering high‑quality data. Three or more years of experience conducting in vivo techniques, including dosing, tissue collection, and related procedures, is required. Preferred Qualifications
Experience working in a pharmaceutical or biotechnology research environment. Experience in working and managing CROs. Hands‑on experience with qPCR assays, including assay development, optimization, and data analysis of in vivo samples. Track record of delivering data for regulatory submissions or IND‑enabling packages. Excellent written and verbal communication skills, with the ability to present data clearly to multidisciplinary teams. Compensation & Benefits
If you are based in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary for new hires ranges $140,250 to $233,750. This position also offers an annual bonus and eligibility to participate in a share‑based long‑term incentive program. Benefits include health care and other insurance benefits for employee and family, retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave. Please visit
GSK US Benefits Summary
to learn more about the comprehensive benefits program. Why GSK?
Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company with a purpose to unite science, technology and talent to move ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, focus on four therapeutic areas, and create an environment where people can thrive. Important Notice to Employment Businesses/Agencies
GSK does not accept referrals from employment businesses and/or agencies for vacancies posted on this site. All employment businesses/agencies must obtain prior written authorization from GSK’s commercial and general procurement/human resources department before referring candidates. GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law. Contact
For adjustments to our process to demonstrate strengths and capabilities, contact
HR.AmericasSC-CS@gsk.com
where you can also request a call. For general inquiries not related to adjustments, please see the Recruitment FAQ guide:
link .
#J-18808-Ljbffr