Director, Business Strategy & Operations - Commercialization

Director, Business Strategy & Operations - Commercialization

Waltham, MA

Company Overview:

Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD), and preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families, and communities. Learn more: and follow us on X, LinkedIn and Facebook.

Role Summary:

As Dyne advances toward commercial launch across multiple therapy areas, we are seeking an experienced Business Strategy and Operations leader to play a central role in shaping and executing our transition from late-stage development to a fully integrated commercial company.

The Director, Business Strategy & Operations - Commercialization will play a critical role in enabling the Commercial organization to operate with clarity, alignment, and executional excellence as Dyne advances toward launch. Acting as a senior strategic and operational partner to the Chief Commercial Officer, this leader ensures that commercial priorities are translated into well-defined, coordinated, and measurable action across the organization.

This role sits at a key intersection of strategy, operations, and cross-functional leadership, ensuring that commercial perspectives, priorities, and readiness are clearly embedded in key priority projects and initiatives. The role provides strong operational leadership and continuity to establish a world-class CCO team, helping translate commercial strategy into coordinated action across the organization. The Director will help establish the systems, processes, and operating rhythm needed to drive commercial readiness, support the CCO and Commercial Leadership Team, and ensure the organization remains focused on the highest-value priorities. They will anticipate needs, connect workstreams, and bring structure and consistency to a rapidly evolving environment.

The ideal candidate brings significant biotech experience, strong strategic and analytical capabilities, and excellent judgment. They are comfortable navigating ambiguity, influencing without authority, and simplifying complexity for senior audiences. This is a high-impact role with broad visibility across the enterprise, suited for a leader who thrives in a fast-paced, high-growth setting and is energized by building and enabling high-performing teams.

This is a full-time position based in Waltham, MA.

Primary Responsibilities Include:

• Partner closely with the CCO to translate commercial strategy and priorities into actionable and measurable plans, ensuring clarity, structure, and consistency across initiatives.
• Establish and manage the operating rhythm for the Commercial organization, including leadership forums, governance processes, decision-focused meetings, and business reviews that drive alignment and follow-through.
• Lead and coordinate high-priority, cross-functional initiatives essential to commercial readiness, serving as the central connector between Commercial and partner functions with clear roles, responsibilities, and timelines.
• Develop and deliver high-quality executive materials, including Board updates, enterprise presentations, town hall content, and cross-functional communications in partnership with Corporate Affairs.
• Support preparation and coordination for the CCO’s engagement with key external stakeholders, such as KOLs, HCPs, patient advocacy groups, strategic partners, and internal senior leaders. Ensure interactions are well-prepared, coordinated, and grounded in a clear understanding of priorities and context.
• Drive operational excellence through OKRs (objectives and key results for the CCO team), dashboards, performance tracking, and business review processes, providing transparency on progress, dependencies, risks, and resource needs.
• Promote alignment, communication, and collaboration across Commercial and partner functions to ensure connectivity between strategy and execution.
• Help strengthen Commercial team culture by reinforcing collaboration, accountability, and clear communication as the organization grows and prepares for launch.

Leadership Characteristics

• Personal leadership characteristics will be critical to success in this role. The successful individual will be highly self-directed, with the judgment, energy, diligence, and resilience required to operate effectively in a high-growth, fast-paced biotechnology environment. They will bring a calm, confident leadership presence, strong communication skills, well-articulated, and the ability to influence and align stakeholders across the organization without formal authority.
• Consistent with Dyne Therapeutics’ values and patient-centered culture, the individual must demonstrate a genuine commitment to listening to, learning from, and acting in the best interests of the patient communities and shareholders Dyne serves.
• A natural alignment with Dyne Therapeutics’ values, including accountability, collaboration, and a deep respect for the needs and experiences of patients and their families.
• The maturity and discretion required to handle sensitive information and complex organizational dynamics.

Education, Experience, and Skills Requirements:

• 10+ years of progressive experience in biotechnology or pharmaceuticals.
• Bachelor’s degree required; advanced degree (MBA, PharmD, PhD) preferred.
• Experience supporting at least two successful rare disease product launches in a commercial, strategic, or operational leadership capacity.
• Strong cross-functional leadership experience in high-growth, dynamic environments.
• Exceptional communication, organization, and influencing skills; able to simplify complex topics for senior audiences.
• Highly self-directed and effective in ambiguity; strong judgment, prioritization, and follow-through.
• Demonstrated ability to handle confidential information with discretion and build trusted relationships at all levels.
• Thrives in dynamic, stretching environments with evolving needs.
• Ability to travel as needed; up to 25%.

MA Pay Range

$188,000 - $230,000 USD

The pay range reflects the base pay range Dyne reasonably expects to pay for this role at the time of posting. Individual compensation depends on factors such as education, experience, job-related knowledge, and demonstrated skills.

The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.

Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

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