Director / Senior Director, Pioneering and Platform Integration (P&PI) Operation

Director/Senior Director, P&PI Strategy & Operations

About P&PI (Pioneering & Platform Integration)

The Pioneering & Platform Integration (P&PI) team at Flagship Pioneering plays a critical role in advancing Flagship’s mission to conceive, create, resource, and grow first-in-category life science companies. P&PI partners closely with platform companies and the broader Flagship ecosystem to ensure alignment across strategic priorities, portfolio development, and R&D governance. The team drives integration of platform insights and operational excellence across early-stage programs, enabling data-driven decisions and execution at scale.

About Flagship Pioneering

Flagship Pioneering conceives, creates, resources, and develops first-in-category life science platform companies to transform human health and sustainability. Since its founding in 2000, the firm has originated and fostered over 100 scientific ventures, generating more than $34 billion in aggregate value and conducting over 50 clinical trials for novel therapeutic agents.

Position Summary

The Director/Senior Director, P&PI Strategy & Operations, co-owns the design and evolution of P&PI’s operating model and portfolio management infrastructure in partnership with P&PI leaders. This role is responsible for shaping the frameworks, processes and tools that support pipeline prioritization, portfolio clarity and cross-functional execution within P&PI.

In addition to leading the strategy and performance of the Product & Partnering Review Committee (PPRC), this individual helps define how portfolio discussions are structured, how work is prioritized and how outputs translate into coordinated execution. The role bridges strategy and operations—ensuring that portfolio frameworks are practical, governance forums are effective, and the broader P&PI body of work is organized and aligned.

Reporting to the COO, Product & Partnering, the Director/Senior Director manages the Associate Director, P&PI Strategy & Operations, and is accountable for both the strategic direction and operational effectiveness of P&PI’s core processes and enabling systems.

Key Responsibilities

Co‑lead the design and refinement of P&PI’s operating model in collaboration with P&PI leadership and the COO of Product & Partnering. Clarify engagement models, decision rights and interfaces across Product & Partnering functions to ensure that portfolio strategy and execution are supported by a clear and durable structure.

Drive the strategy, structure and effectiveness of the Product & Partnering Review Committee (PPRC). Define objectives and meeting architecture, shape decision outputs, clarify expectations for materials and analysis, and ensure that the forum evolves as portfolio needs change.

Co‑lead the development of pipeline and indications strategy frameworks, value frameworks and related portfolio tools. Establish consistent approaches to asset prioritization, define stage‑appropriate deliverables (including commercial and financial outputs) and support value pool mapping and portfolio visibility efforts. Ensure that pipeline discussions are supported by clear analytical structures and consistent documentation.

Oversee management of the broader P&PI body of work, including initiative tracking, prioritization processes and execution monitoring. Ensure transparency into commitments and progress, elevate emerging risks or bottlenecks and support informed decision‑making regarding sequencing and focus.

When appropriate and based on experience and portfolio needs, flex to support the development of pipeline and asset strategies. This may include co‑developing strategy frameworks, structuring portfolio trade‑off discussions, synthesizing competitive and portfolio insights and preparing executive‑ready materials for leadership decision‑making.

Minimum Qualifications

• 10+ years of experience in operations, portfolio management or program governance within biotechnology, pharmaceuticals or a related R&D environment.
• Proven ability to manage governance workflows and cross‑functional communications.
• Exceptional organizational and prioritization skills with keen attention to detail.
• Strong written and verbal communication skills; able to synthesize discussions into actionable summaries.
• Proficiency with collaboration and tracking tools (e.g., SharePoint, Smartsheet, Notion, Microsoft Office, AI‑based productivity tools).
• Demonstrated ability to partner across scientific, operational and leadership teams in a fast‑paced, evolving environment.
• High degree of professionalism, discretion and accountability.

Values and Behaviors

• Entrepreneurial spirit and mission‑oriented toward enabling breakthrough innovation.
• Courage to take initiative and drive improvements across teams and processes.
• Collaborative mindset with strong interpersonal and communication skills.
• Commitment to fostering a growth‑oriented, high‑energy environment.
• Accountability for high‑quality execution and follow‑through.

What We Offer

• Impactful role in a company recognized for transformative contributions to human health and sustainability.
• Dynamic culture with inspiring colleagues and leaders.
• Support for professional development and growth in an innovative environment.
• Comprehensive employee benefits and rewards program.

Flagship has been recognized twice on FORTUNE’s “Change the World” list and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies.

Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID‑19, curing intractable diseases, improving human health, preempting illness and feeding the world by improving the resiliency and sustainability of agriculture. Learn more at At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact.

We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status or any other characteristic protected by law.

We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

The salary range for this role is $172,000 - $280,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies and experience. Flagship Pioneering currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Flagship Pioneering’s good faith estimate as of the date of publication and may be modified in the future.

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