Global Development Product Lead (Sr Director)
Pfizer, Phila, PA, United States
Job Responsibilities
Lead multiple (1–3) cross‑functional oncology product teams from pre‑clinical candidate nomination (CAN) through Phase 1–2 clinical development and proof‑of‑concept (POC) stages, after which the molecule may be handed to the late‑stage Oncology Development team for post‑POC (typically Phase 3) development.
In close collaboration with functional experts, drive the effective integration of an end‑to‑end cross‑functional molecule strategy and risk mitigation plan, ensuring delivery of data‑driven milestones through successful risk identification and mitigation.
Support clinical trials and the development strategy for early‑development assets and lead development programs across multiple functions within Pfizer Oncology, representing the program to the external clinical community.
Develop a clinical development plan from first‑in‑human clinical trial to proof‑of‑concept, including assessment of appropriate combinations and evaluation of potential predictive and pharmacodynamic biomarker plans.
Ensure the clinical components of plans and clinical expertise are provided to project teams, including medical monitoring of clinical trials.
Lead, develop and execute strategic development for early‑development assets, collaborating with line‑function experts on Global Product Teams (GPTs) to develop and drive an integrated product plan that addresses near‑term technical uncertainties and aligns with future pivotal development and commercialization success.
Ensure timely execution and delivery of product milestones within budget.
Communicate with executive management and governance committees to address program needs and provide recommendations; ensure clear and effective product presentations and communications.
Collaborate with partners on co‑development programs to deliver a shared global product strategy, when applicable.
Lead the team to set objectives, prioritize tasks, and ensure adherence to the plan and strategy.
Manage risk by proactively identifying and resolving issues and developing contingency plans.
Oversee early‑development assets’ development broadly within a specific indication or group of indications, typically working on at least two clinical programs and supporting multiple research projects.
Work across the organization and on multifunctional teams responsible for the development of early‑development assets (Product Team, Global Development Team, and Study team).
Oversee the development and management of clinical protocols and amendments, investigator brochures, clinical study reports, statistical analysis plans, and regulatory documents.
Provide leadership to early‑stage clinical scientists on the clinical study team for Early Development Assets, working in a matrix team environment with clinicians, statisticians, clinical pharmacologists, translational biologists, and regulatory specialists.
Implement PK‑guided dose escalation, early combination strategies, and emerging innovations on all Oncology R&D first‑in‑human clinical trials with input from Pfizer Oncology’s Oncology Research Unit, Regulatory Strategy, Clinical Pharmacology, Precision Medicine, Clinical Development and Operations, Pharm Sci and Product Teams.
Oversee the evaluation of safety, pharmacology, and efficacy data from ongoing and completed studies for early‑development assets.
Oversee manuscripts, abstracts, and presentations for scientific meetings and advisory boards.
Conduct literature reviews and prepare summaries to support clinical development programs.
Serve as medical resource for design and interpretation of clinical and preclinical programs to support existing and new development candidates.
Coordinate regular (at least quarterly and as needed) interactions with preferred clinical trials network and KOL advisory board to objectively consider and implement feedback.
Drive innovations in early clinical development, and the application of translational oncology and precision medicine approaches.
Collaborate with cross‑functional leaders and teams to translate early preclinical discovery research into therapeutic candidates.
Coordinate with business development to establish strategic external collaborations and foster new research projects and programs.
Contribute to broader organizational excellence as a member of the OESD department by creating a positive team environment that fosters trust, encourages disconfirming information, and promotes clear communication to align the team around the overall goal and vision for the product.
Qualifications
MD or MD‑PhD with 5+ years of industry experience (required).
Oncology drug development experience, track record in oncology clinical research including early‑phase drug development (preferred).
Clinical oncology experience; Board certification in oncology preferred.
Significant industry leadership experience in clinical, translational or basic research in biomedical sciences or related disciplines.
Understanding of related disciplines (e.g., biostatistics, regulatory, pre‑clinical pharmacology, pharmaceutical sciences).
Demonstrated scientific productivity (publications, abstracts, etc.).
Proven scientific writing and communication skills.
Proven leadership skills with ability to defend the clinical plan at governance meetings.
Capacity to adapt to a fast‑paced and changing environment.
Demonstrated history of effective leadership, including cross‑functional and matrixed teams, managing direct reports when applicable, and ensuring alignment with cross‑functional leaders.
Passion for helping patients with cancer and for the science of oncology.
Proactive and strategic thinker with strong data‑driven decision‑making skills.
Ability to focus and motivate a team in a matrix organization with multiple stakeholders.
Strong verbal, written, and presentation communication skills.
Experience in staff management with effective mentoring.
Highly collaborative with outstanding relationship‑building skills with internal leadership, external partners, and investigators/medical professionals.
Strong leadership presence; ability to work effectively with other leaders.
Team player, works well in a team environment as both leader and contributor.
Global perspective with ability to work effectively with colleagues from diverse cultures, backgrounds, and geographies.
Organizational Relationships Early‑stage clinical scientists on the clinical study team for Early Development Assets, clinicians, statisticians, clinical pharmacologists, translational biologists, regulatory specialists, pharmaceutical scientists, commercial strategy representatives, and other Pfizer Oncology group leaders/surrogates across functions. In addition, chairs of strategic oversight committees (head of oncology early‑stage development + line‑function leaders on governance bodies), direct line managers of line‑function experts assigned to cross‑functional molecule teams, governance committees and molecule development teams of contractual external partners, and BD team including due diligence teams.
Resources Managed
Manage individual product team annual clinical trial budget and projected operational plans for the coming years: $20‑100M.
This position does not manage direct reports.
Candidate Profile Candidate demonstrates a breadth of diverse leadership experiences and capabilities including the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.
Relocation Support Relocation support may be available.
Work Location Assignment This is a hybrid role requiring you to live within commuting distance and work on‑site an average of 2.5 days per week.
Salary and Benefits The annual base salary for this position ranges from $274,500.00 to $457,500.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 25.0% of the base salary and eligibility to participate in our share‑based long‑term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Visa Sponsorship U.S. work visa sponsorship (such as TN, O‑1, H‑1B, etc.) is not available for this role now or in the future.
Sunshine Act Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E‑Verify employer. This position requires permanent work authorization in the United States. Pfizer endeavors to make www.pfizer.com/careers accessible to all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process and/or interviewing, please email disabilityrecruitment@pfizer.com. This is to be used solely for accommodation requests with respect to the accessibility of our website, online application process and/or interviewing. Requests for any other reason will not be returned.
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Lead multiple (1–3) cross‑functional oncology product teams from pre‑clinical candidate nomination (CAN) through Phase 1–2 clinical development and proof‑of‑concept (POC) stages, after which the molecule may be handed to the late‑stage Oncology Development team for post‑POC (typically Phase 3) development.
In close collaboration with functional experts, drive the effective integration of an end‑to‑end cross‑functional molecule strategy and risk mitigation plan, ensuring delivery of data‑driven milestones through successful risk identification and mitigation.
Support clinical trials and the development strategy for early‑development assets and lead development programs across multiple functions within Pfizer Oncology, representing the program to the external clinical community.
Develop a clinical development plan from first‑in‑human clinical trial to proof‑of‑concept, including assessment of appropriate combinations and evaluation of potential predictive and pharmacodynamic biomarker plans.
Ensure the clinical components of plans and clinical expertise are provided to project teams, including medical monitoring of clinical trials.
Lead, develop and execute strategic development for early‑development assets, collaborating with line‑function experts on Global Product Teams (GPTs) to develop and drive an integrated product plan that addresses near‑term technical uncertainties and aligns with future pivotal development and commercialization success.
Ensure timely execution and delivery of product milestones within budget.
Communicate with executive management and governance committees to address program needs and provide recommendations; ensure clear and effective product presentations and communications.
Collaborate with partners on co‑development programs to deliver a shared global product strategy, when applicable.
Lead the team to set objectives, prioritize tasks, and ensure adherence to the plan and strategy.
Manage risk by proactively identifying and resolving issues and developing contingency plans.
Oversee early‑development assets’ development broadly within a specific indication or group of indications, typically working on at least two clinical programs and supporting multiple research projects.
Work across the organization and on multifunctional teams responsible for the development of early‑development assets (Product Team, Global Development Team, and Study team).
Oversee the development and management of clinical protocols and amendments, investigator brochures, clinical study reports, statistical analysis plans, and regulatory documents.
Provide leadership to early‑stage clinical scientists on the clinical study team for Early Development Assets, working in a matrix team environment with clinicians, statisticians, clinical pharmacologists, translational biologists, and regulatory specialists.
Implement PK‑guided dose escalation, early combination strategies, and emerging innovations on all Oncology R&D first‑in‑human clinical trials with input from Pfizer Oncology’s Oncology Research Unit, Regulatory Strategy, Clinical Pharmacology, Precision Medicine, Clinical Development and Operations, Pharm Sci and Product Teams.
Oversee the evaluation of safety, pharmacology, and efficacy data from ongoing and completed studies for early‑development assets.
Oversee manuscripts, abstracts, and presentations for scientific meetings and advisory boards.
Conduct literature reviews and prepare summaries to support clinical development programs.
Serve as medical resource for design and interpretation of clinical and preclinical programs to support existing and new development candidates.
Coordinate regular (at least quarterly and as needed) interactions with preferred clinical trials network and KOL advisory board to objectively consider and implement feedback.
Drive innovations in early clinical development, and the application of translational oncology and precision medicine approaches.
Collaborate with cross‑functional leaders and teams to translate early preclinical discovery research into therapeutic candidates.
Coordinate with business development to establish strategic external collaborations and foster new research projects and programs.
Contribute to broader organizational excellence as a member of the OESD department by creating a positive team environment that fosters trust, encourages disconfirming information, and promotes clear communication to align the team around the overall goal and vision for the product.
Qualifications
MD or MD‑PhD with 5+ years of industry experience (required).
Oncology drug development experience, track record in oncology clinical research including early‑phase drug development (preferred).
Clinical oncology experience; Board certification in oncology preferred.
Significant industry leadership experience in clinical, translational or basic research in biomedical sciences or related disciplines.
Understanding of related disciplines (e.g., biostatistics, regulatory, pre‑clinical pharmacology, pharmaceutical sciences).
Demonstrated scientific productivity (publications, abstracts, etc.).
Proven scientific writing and communication skills.
Proven leadership skills with ability to defend the clinical plan at governance meetings.
Capacity to adapt to a fast‑paced and changing environment.
Demonstrated history of effective leadership, including cross‑functional and matrixed teams, managing direct reports when applicable, and ensuring alignment with cross‑functional leaders.
Passion for helping patients with cancer and for the science of oncology.
Proactive and strategic thinker with strong data‑driven decision‑making skills.
Ability to focus and motivate a team in a matrix organization with multiple stakeholders.
Strong verbal, written, and presentation communication skills.
Experience in staff management with effective mentoring.
Highly collaborative with outstanding relationship‑building skills with internal leadership, external partners, and investigators/medical professionals.
Strong leadership presence; ability to work effectively with other leaders.
Team player, works well in a team environment as both leader and contributor.
Global perspective with ability to work effectively with colleagues from diverse cultures, backgrounds, and geographies.
Organizational Relationships Early‑stage clinical scientists on the clinical study team for Early Development Assets, clinicians, statisticians, clinical pharmacologists, translational biologists, regulatory specialists, pharmaceutical scientists, commercial strategy representatives, and other Pfizer Oncology group leaders/surrogates across functions. In addition, chairs of strategic oversight committees (head of oncology early‑stage development + line‑function leaders on governance bodies), direct line managers of line‑function experts assigned to cross‑functional molecule teams, governance committees and molecule development teams of contractual external partners, and BD team including due diligence teams.
Resources Managed
Manage individual product team annual clinical trial budget and projected operational plans for the coming years: $20‑100M.
This position does not manage direct reports.
Candidate Profile Candidate demonstrates a breadth of diverse leadership experiences and capabilities including the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.
Relocation Support Relocation support may be available.
Work Location Assignment This is a hybrid role requiring you to live within commuting distance and work on‑site an average of 2.5 days per week.
Salary and Benefits The annual base salary for this position ranges from $274,500.00 to $457,500.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 25.0% of the base salary and eligibility to participate in our share‑based long‑term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Visa Sponsorship U.S. work visa sponsorship (such as TN, O‑1, H‑1B, etc.) is not available for this role now or in the future.
Sunshine Act Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E‑Verify employer. This position requires permanent work authorization in the United States. Pfizer endeavors to make www.pfizer.com/careers accessible to all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process and/or interviewing, please email disabilityrecruitment@pfizer.com. This is to be used solely for accommodation requests with respect to the accessibility of our website, online application process and/or interviewing. Requests for any other reason will not be returned.
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