Senior Director, ADME

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver‑directed THR‑β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic, inclusive, and high‑performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

The Senior Director, ADME will provide technical leadership and execution for ADME activities supporting non‑clinical and clinical development programs. This role is primarily responsible for non‑clinical ADME strategy and oversight, while supporting Clinical Pharmacology and early clinical development as a subject matter expert.

This individual will bring deep expertise in drug metabolism, with working knowledge across broader ADME disciplines, and will oversee all ADME studies conducted through CRO partners. The role requires strong hands‑on scientific judgment to design, interpret, and integrate ADME data to support program decisions and regulatory submissions.

Key Responsibilities

Serve as the ADME subject matter expert, with deep expertise in metabolism

Define and execute ADME strategies in collaboration with functional area leads

Design, oversee, and interpret non‑clinical ADME studies (in vitro and in vivo)

Manage CROs, including vendor selection, study design, protocol development, and report review

Ensure ADME data are scientifically sound and aligned with regulatory expectations

Support clinical development through ADME input, including DDI risk assessment, PBPK modeling, and human ADME (mass balance) study design and interpretation

Integrate non‑clinical and emerging clinical PK data to inform ADME strategy and study design

Author and review ADME sections of regulatory submissions (IND/CTA, NDA) and support regulatory interactions

Qualifications
Education & Experience

Ph.D. in Pharmacokinetics, Drug Metabolism, Pharmaceutical Sciences, or related discipline (or equivalent experience)

15+ years of ADME experience in pharmaceutical or biotechnology drug development

Experience supporting both non‑clinical and clinical programs

Technical Expertise

Deep expertise in drug metabolism (required)

Working knowledge of transporters and broader ADME sciences

Strong experience designing and interpreting ADME studies

Experience with PBPK modeling and human ADME (mass balance) studies preferred

Core Competencies

Strong scientific judgment and attention to detail

Hands‑on, execution‑focused approach

Effective communicator within technical and cross‑functional teams

Ability to operate in a fast‑paced, dynamic environment

Compensation & Benefits
Madrigal’s Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. All employees receive equity, allowing them to share in the company’s success. Base salary is determined by several factors including the candidate’s qualifications, skills, education, experience, business needs and market demands. As of the date of this posting, the current pay scale for this position is $256,000 - $313,000 per year. We comply with all applicable minimum wage laws.

Full‑time employees are eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (traditional, Roth, and employer match). Additional voluntary benefits include supplemental life insurance, legal services, and other offerings. Mental health benefits are provided through an Employee Assistance Program for employees and their families. The company also offers other benefits in accordance with applicable federal, state, and local laws.

Equal Opportunity Statement
Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex, gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law.

Reasonable Accommodations
We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact HR@madrigalpharma.com.

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