Executive Director, Digital Enablement

The Executive Director, Digital Enablement (DE) is a newly created role with a mandate to ensure that digital and AI capabilities give Vaxcyte better leverage across every launch function. Initially focused on the commercial launch of VAX-31 for the adult indication, this role will lead the build of the digital infrastructure, AI capabilities, and commercial technology roadmap from the ground up for Vaxcyte as a first-time launching company.

The Executive Director, DE serves as an enabler across functions, designing systems and capabilities so that Marketing, Sales, Medical Affairs, Market Access, Commercial Operations, Data and Analytics, and any other commercial teams have less friction, better intelligence, and more leverage than the competition. This role sits within the Commercial organization and works in close partnership with the IT Commercial Lead (ITCL) in the IT function, who will own implementation, data security, and technical management.

This role also supports the digital, data, and AI needs of Medical Affairs while respecting the independence of Medical Affairs in setting its own scientific strategy, content, and engagement priorities.

Commercial Digital Strategy and Product Roadmap

~Develop a phased commercial digital vision for the US adult launch covering pre-launch, launch, and growth phases, with defined milestones and measurable outcomes at each stage.

~Own and maintain a commercial product roadmap that treats each digital capability — CRM, marketing technology, field enablement, analytics, AI tools — as a discrete product with a use case, a user, a success metric, and a release schedule.

~Map the end-to-end commercial experience from the account manager and field rep perspective through to provider and executive touchpoints, identifying where digital creates genuine leverage and where added complexity should be avoided.

~Define and prioritize AI use cases for field force effectiveness, marketing operations, customer segmentation, content production, and performance analytics — sequenced by business impact and data readiness.

~Ensure that no technology decision precedes a defined commercial use case; Serve as the commercial voice in all digital and technology planning conversations, ensuring that field, marketing, Medical Affairs, Market Access, and commercial operations priorities drive decisions.

~Translate commercial strategy into language that IT, vendors, and data teams can build from; translate technical constraints and trade-offs into language that commercial leaders can act on.

~Partner with Marketing to build the martech stack, performance marketing capability, and content infrastructure, and to streamline MLR review so approved content reaches the field faster.

~Partner with Sales and Field Force Excellence to equip the field with CRM, call planning, territory management, and mobile tools that make reps more effective in front of customers.

~Partner with Medical Affairs to build capabilities to enable and enhance Medical Affairs activities, including digital engagement, scientific exchange tools, congress engagement platforms, and KOL mapping.

~Partner with Market Access and Commercial Operations to stand up contract management, chargeback and revenue management, and Sunshine Act compliance workflows that hold up under launch volume.

~Serve as the primary liaison to the IT Commercial Lead (ITCL), ensuring technology implementation aligns with commercial strategy.

~AI-First Capability Building

~Examine every commercial launch capability area for where AI changes how the work gets done.

~Approach every commercial capability decision with an AI-first lens.

~Define and lead the AI capability roadmap for the commercial and medical affairs organizations.

~Deploy AI-powered strategic tools for the commercial leadership team.

~Champion AI literacy and adoption across commercial functions.

~Establish AI governance guardrails for commercial contexts in partnership with Legal and Compliance.

~Vendor and Platform Governance

~Lead commercial evaluation of CRM, marketing automation, data, and AI vendor options.

~Maintain a composable, modular platform philosophy.

~Ensure that vendor contracts entered by the ITCL have commercial sign-off on scope, functionality, and success criteria before execution.

~Data Strategy and Commercial Performance Reporting

~Define the commercial data strategy.

~Partner with the ITCL to create the data architecture necessary to track and report commercial progress.

~Partner with IT and Finance to ensure a commercial view within the master data management framework.

~Drive adoption of performance analytics and reporting tools across the commercial team.

BA/BS degree in a scientific discipline, business, marketing, or technology required.

~MBA or other advanced degree highly desired.

~Minimum of 15+ years of industry-related experience with 5+ years in commercial or commercial-facing roles within pharmaceutical, biotech, or vaccine organizations.

~Experience building or leading a commercial digital or commercial excellence function.

~Deep understanding of the commercial technology ecosystem.

~Deep understanding of frontier AI models and their applications in business.

~Proven ability to translate in both directions: commercial strategy into technical requirements, and technical constraints into business options.

~AI fluency: genuine working knowledge of generative AI, predictive analytics, next-best-action tools, and AI-assisted content workflows.

~Familiarity with revenue management infrastructure including chargebacks, rebates, and gross-to-net systems.

~Familiarity with Sunshine Act compliance, MLR review workflows, and promotional materials management.

~Ability to travel 20% of the time for commercial and cross-functional team engagements.

Chief Commercial Officer

~Location: US – Philadelphia/Remote

~Remote

~Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component.

~Relocation: This role is eligible for relocation assistance.

Equity component.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status.