Role:
Senior Scientist in Discovery & Translational Research responsible for establishing and executing research-grade AAV manufacturing for gene therapy programs.
Responsibilities:
- independently perform all phases of AAV production, including cell culture, transfection, purification, characterization, and release;
- optimize workflows;
- troubleshoot processes;
- collaborate with Discovery, Analytical Development, and CMC teams to ensure research material quality and alignment with development needs;
- maintain compliant laboratory operations.
Requirements:
- B.S. or M.S. in Molecular Biology, Cell Biology, Biochemistry, or related field;
- 5+ years industry experience in AAV production, process development, or gene therapy research;
- hands-on expertise in upstream/downstream AAV processing, analytical characterization, and process troubleshooting;
- strong understanding of AAV quality attributes and testing coordination;
- experience establishing research-grade workflows and documentation.
HighValue:
- gene therapy
- AAV vectors
- research-stage manufacturing
- process development
- analytical characterization
- Durham, NC
- salary $140K–$160K
- collaborative research environment