Experteer Italy
Principal Scientist, Biologic AI Research and Design
Experteer Italy, Cambridge, Massachusetts, us, 02140
As a (Senior) Principal Scientist in the Protein Design and Informatics (PDI) team, you will focus on developing, integrating, and embedding bleeding‑edge computational methods and predictive in‑silico models that drive the discovery of new medicines and vaccines. Included in the larger Data, Automation, and Predictive Sciences (DAPS) department, you will be the predictive engine for R&D, focusing on researching and embedding new methods to enable the vision of automation of the entire Design‑Make‑Test‑Analyze cycle, driving Lab‑in‑an‑Automated‑Loop frameworks from target discovery to the clinic – all stages of a therapeutic project.
You’ll have the opportunity to work in close partnership with many departments across GSK, developing and fostering a high‑performing team culture of collaboration, curiosity, consistency, agility, quality, peer review, and continuous improvement with a relentless focus on creating medicines for patients.
We create a place where people can grow, be their best, be safe, and feel welcome, valued and included.
We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, a pension plan membership, and shares and savings programme.
Responsibilities
Generate, validate, and integrate multimodal generative AI/ML models for the de‑novo design and multi‑objective optimisation of tool and therapeutic biologics, such as miniproteins, antibodies, antigens, peptides, ADCs, and oligonucleotides.
Build and exploit agent‑orchestrated, integrated Design‑Make‑Test‑Analyse cycles with automated experimental platforms, generating quality data at scale needed for project‑specific and foundational models.
Innovate, develop, and apply predictive models for protein design and developability engineering, utilising large‑scale NGS, patient‑derived, and other proprietary in‑house and external data sources.
Identify and advocate for the opportunities afforded by scientific computation and platform automation and drive therapeutic project plans with predictive technologies.
Collaborate with external groups to further develop protein engineering computational methods.
Predict and evaluate potential disease intervention points for their probability of success to be therapeutically modulated across any modality.
Qualifications Basic Qualifications & Skills
PhD or equivalent in Bioinformatics, Physics, Chemistry, Computer Science, Structural Biology, or related fields.
Experience in protein structural or sequence analysis.
Experience in one or more programming languages (e.g. Python).
Experience working as a team lead or member; ability to work/lead effectively in a matrix environment.
Experience working across scientific and technical disciplines to deliver impactful solutions that drive project progression.
Preferred Qualifications & Skills
Experience developing or applying modern ML architectures for protein design models (LLMs, diffusion models, flow‑matching, Bayesian optimisation, GNNs, etc.).
Experience with training or applying multimodal input (sequence, structure, small and large molecular representations, etc.) and output (imaging, omics, etc.) foundational models.
Experience designing de‑novo binders for specified targets and epitopes to answer biological questions.
Experience with cloud engineering production‑ready robust and scalable scientific workflows.
Experience building and deploying agentic workflows.
Experience analysing NGS‑derived antibody repertoires for sequence‑ and structure‑based design.
Experience predicting structures of RNA or nucleic acid‑protein complexes.
Experience with molecular simulation and conformational analysis techniques.
Demonstrated learning agility, scientific curiosity, and focus on driving greater impact in the face of uncertainty and change.
Ability to generate conclusion reports, present data in team meetings, and participate in writing of abstracts and publications for the scientific community.
Why GSK? Uniting science, technology and talent to get ahead of disease together – we aim to positively impact the health of 2.5 billion people by the end of the decade.
GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together.
We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.
Salary range: $121,275 – $202,125 (U.S.).
This position offers an annual bonus and eligibility to participate in our share‑based long‑term incentive program.
GSK is an Equal Opportunity Employer.
This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information, military service or any basis prohibited under federal, state or local law.
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You’ll have the opportunity to work in close partnership with many departments across GSK, developing and fostering a high‑performing team culture of collaboration, curiosity, consistency, agility, quality, peer review, and continuous improvement with a relentless focus on creating medicines for patients.
We create a place where people can grow, be their best, be safe, and feel welcome, valued and included.
We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, a pension plan membership, and shares and savings programme.
Responsibilities
Generate, validate, and integrate multimodal generative AI/ML models for the de‑novo design and multi‑objective optimisation of tool and therapeutic biologics, such as miniproteins, antibodies, antigens, peptides, ADCs, and oligonucleotides.
Build and exploit agent‑orchestrated, integrated Design‑Make‑Test‑Analyse cycles with automated experimental platforms, generating quality data at scale needed for project‑specific and foundational models.
Innovate, develop, and apply predictive models for protein design and developability engineering, utilising large‑scale NGS, patient‑derived, and other proprietary in‑house and external data sources.
Identify and advocate for the opportunities afforded by scientific computation and platform automation and drive therapeutic project plans with predictive technologies.
Collaborate with external groups to further develop protein engineering computational methods.
Predict and evaluate potential disease intervention points for their probability of success to be therapeutically modulated across any modality.
Qualifications Basic Qualifications & Skills
PhD or equivalent in Bioinformatics, Physics, Chemistry, Computer Science, Structural Biology, or related fields.
Experience in protein structural or sequence analysis.
Experience in one or more programming languages (e.g. Python).
Experience working as a team lead or member; ability to work/lead effectively in a matrix environment.
Experience working across scientific and technical disciplines to deliver impactful solutions that drive project progression.
Preferred Qualifications & Skills
Experience developing or applying modern ML architectures for protein design models (LLMs, diffusion models, flow‑matching, Bayesian optimisation, GNNs, etc.).
Experience with training or applying multimodal input (sequence, structure, small and large molecular representations, etc.) and output (imaging, omics, etc.) foundational models.
Experience designing de‑novo binders for specified targets and epitopes to answer biological questions.
Experience with cloud engineering production‑ready robust and scalable scientific workflows.
Experience building and deploying agentic workflows.
Experience analysing NGS‑derived antibody repertoires for sequence‑ and structure‑based design.
Experience predicting structures of RNA or nucleic acid‑protein complexes.
Experience with molecular simulation and conformational analysis techniques.
Demonstrated learning agility, scientific curiosity, and focus on driving greater impact in the face of uncertainty and change.
Ability to generate conclusion reports, present data in team meetings, and participate in writing of abstracts and publications for the scientific community.
Why GSK? Uniting science, technology and talent to get ahead of disease together – we aim to positively impact the health of 2.5 billion people by the end of the decade.
GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together.
We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.
Salary range: $121,275 – $202,125 (U.S.).
This position offers an annual bonus and eligibility to participate in our share‑based long‑term incentive program.
GSK is an Equal Opportunity Employer.
This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information, military service or any basis prohibited under federal, state or local law.
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