Mount Sinai Health System
Job Overview
Department:
Division of Gastroenterology
Location:
1425 Madison Ave, New York, NY 10029
PI / Supervisor:
Saurabh Mehandru
Administrative Contact:
Erica Krasny
Qualifications
PhD or MD (PhD preferred)
Expected Outcomes Ultimately, the expectations we may have from this project are to
support the development of tailored therapeutic strategies
that best suit immunocompromised individuals, based on a clear understanding of the immune pathways dysregulated. This work may also
unravel new knowledge on how B cells, T cells and myeloid cells control gut homeostasis.
Responsibilities The main objective of my PhD project will be to identify dysregulated immune networks triggering and sustaining inflammation in CVID patients with GI tract disorders. My work will focus on the study of human gastrointestinal biopsies. I will use a
combination of single cell RNA sequencing (scRNA-seq), high dimensional flow cytometry, and whole slide, high-resolution multiplex imagery approaches , to identify the functional alterations of immune cells within the CVID inflamed gut and/or stomach mucosa.
The project will be structured around three specific aims:
Investigating the cellular and molecular organizations of gut inflammatory lesions in CVID.
Addressing the role of B cells and autoantibodies in the pathogenesis of CVID gut inflammatory lesions.
Dissecting altered molecular trajectory of myeloid cells in CVID.
This PhD project will be co-supervised by Prof. Saurabh Mehandru (MD-PhD, Icahn School of Medicine at Mount Sinai, New-York, USA) and Prof. Jérôme Martin (PhD, Nantes University, France). It will be part of an international, pre-existing collaboration between Nantes University and the Icahn School of Medicine at Mount Sinai, contributing to a translational research effort ultimately aimed at benefiting patients.
Equal Opportunity Employer The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported. Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization.
Compensation Statement Mount Sinai Health System (MSHS) provides a salary range to comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $72,500 - $80,000 Annually. Actual salaries depend on a variety of factors, including experience, education, and hospital need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.
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Division of Gastroenterology
Location:
1425 Madison Ave, New York, NY 10029
PI / Supervisor:
Saurabh Mehandru
Administrative Contact:
Erica Krasny
Qualifications
PhD or MD (PhD preferred)
Expected Outcomes Ultimately, the expectations we may have from this project are to
support the development of tailored therapeutic strategies
that best suit immunocompromised individuals, based on a clear understanding of the immune pathways dysregulated. This work may also
unravel new knowledge on how B cells, T cells and myeloid cells control gut homeostasis.
Responsibilities The main objective of my PhD project will be to identify dysregulated immune networks triggering and sustaining inflammation in CVID patients with GI tract disorders. My work will focus on the study of human gastrointestinal biopsies. I will use a
combination of single cell RNA sequencing (scRNA-seq), high dimensional flow cytometry, and whole slide, high-resolution multiplex imagery approaches , to identify the functional alterations of immune cells within the CVID inflamed gut and/or stomach mucosa.
The project will be structured around three specific aims:
Investigating the cellular and molecular organizations of gut inflammatory lesions in CVID.
Addressing the role of B cells and autoantibodies in the pathogenesis of CVID gut inflammatory lesions.
Dissecting altered molecular trajectory of myeloid cells in CVID.
This PhD project will be co-supervised by Prof. Saurabh Mehandru (MD-PhD, Icahn School of Medicine at Mount Sinai, New-York, USA) and Prof. Jérôme Martin (PhD, Nantes University, France). It will be part of an international, pre-existing collaboration between Nantes University and the Icahn School of Medicine at Mount Sinai, contributing to a translational research effort ultimately aimed at benefiting patients.
Equal Opportunity Employer The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported. Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization.
Compensation Statement Mount Sinai Health System (MSHS) provides a salary range to comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $72,500 - $80,000 Annually. Actual salaries depend on a variety of factors, including experience, education, and hospital need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.
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