Mount Sinai Health System
About the Position
The candidate will conduct research that integrates
experimental immunology
with
computational analyses of omics data . The position requires designing, executing, and analyzing both
wet lab assays
and
computational pipelines , with the goal of advancing translational approaches to immunology and transplantation biology. The fellow will prepare manuscripts, present findings at conferences, and collaborate closely with clinicians and scientists.
Specific Research Project The fellow will lead a funded project focused on developing and applying a novel dynamic fluorescent biosensor (FJ375) to evaluate redox homeostasis in T lymphocytes as a biomarker for acute cellular rejection (ACR) in heart transplant recipients.
Project Activities
Characterize the redox metabolic profile of T cell subsets (effector T cells and regulatory T cells) in transplant recipients.
Assess the diagnostic performance of FJ375 for detecting acute cellular rejection, compared with current standards (donor-derived cell-free DNA and gene expression profiling).
Determine the prognostic capacity of redox signatures for predicting persistent rejection.
Explore the influence of immunosuppressive therapy on T cell redox balance through ex vivo assays.
Integrate clinical, immunological, and computational analyses to identify molecular correlates of immune tolerance and risk of rejection.
This project involves both laboratory experiments (flow cytometry, cell culture, redox profiling) and computational modeling of clinical and omics data. The ultimate goal is to develop new biomarkers that improve rejection surveillance and guide personalized immunosuppression strategies in cardiac transplantation.
Qualifications
PhD, MD, or MD/PhD in Immunology, Computational Biology, Bioinformatics, Molecular Biology, or a related field.
Demonstrated expertise in wet lab immunology techniques (e.g., flow cytometry, cell culture, molecular assays).
Experience with computational methods and programming (R, Python, or similar) applied to biological datasets.
Strong initiative, independence, and ability to integrate clinical and basic science questions.
Excellent communication and collaborative skills.
Equal Opportunity Employer The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported.
Compensation The salary range for the role is $72,500 – $80,000 annually. Actual salaries depend on a variety of factors, including experience, education, and operational need. The range listed does not include bonuses, incentives, differential pay, or other forms of compensation or benefits.
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experimental immunology
with
computational analyses of omics data . The position requires designing, executing, and analyzing both
wet lab assays
and
computational pipelines , with the goal of advancing translational approaches to immunology and transplantation biology. The fellow will prepare manuscripts, present findings at conferences, and collaborate closely with clinicians and scientists.
Specific Research Project The fellow will lead a funded project focused on developing and applying a novel dynamic fluorescent biosensor (FJ375) to evaluate redox homeostasis in T lymphocytes as a biomarker for acute cellular rejection (ACR) in heart transplant recipients.
Project Activities
Characterize the redox metabolic profile of T cell subsets (effector T cells and regulatory T cells) in transplant recipients.
Assess the diagnostic performance of FJ375 for detecting acute cellular rejection, compared with current standards (donor-derived cell-free DNA and gene expression profiling).
Determine the prognostic capacity of redox signatures for predicting persistent rejection.
Explore the influence of immunosuppressive therapy on T cell redox balance through ex vivo assays.
Integrate clinical, immunological, and computational analyses to identify molecular correlates of immune tolerance and risk of rejection.
This project involves both laboratory experiments (flow cytometry, cell culture, redox profiling) and computational modeling of clinical and omics data. The ultimate goal is to develop new biomarkers that improve rejection surveillance and guide personalized immunosuppression strategies in cardiac transplantation.
Qualifications
PhD, MD, or MD/PhD in Immunology, Computational Biology, Bioinformatics, Molecular Biology, or a related field.
Demonstrated expertise in wet lab immunology techniques (e.g., flow cytometry, cell culture, molecular assays).
Experience with computational methods and programming (R, Python, or similar) applied to biological datasets.
Strong initiative, independence, and ability to integrate clinical and basic science questions.
Excellent communication and collaborative skills.
Equal Opportunity Employer The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported.
Compensation The salary range for the role is $72,500 – $80,000 annually. Actual salaries depend on a variety of factors, including experience, education, and operational need. The range listed does not include bonuses, incentives, differential pay, or other forms of compensation or benefits.
#J-18808-Ljbffr