Senior Director/Vice President, Preclinical Pharmacology & Toxicology

Benefits

• 401(k) matching
• Competitive salary
• Dental insurance
• Free food & snacks
• Health insurance
• Paid time off

Position Overview

Salubris Biotherapeutics is seeking a visionary and experienced leader to join our team as Senior Director or Vice President, Preclinical Pharmacology & Toxicology .

This foundational leadership role offers the opportunity to further establish and lead the Preclinical Pharmacology, Pharmacometrics, and Toxicology function, driving research programs from lead optimization through IND submission.

The SD/VP will be responsible for integrating nonclinical pharmacology, toxicology, and pharmacokinetics into the company’s R&D strategy, ensuring alignment with regulatory and scientific standards. This strategic leadership role guides non‑clinical assessments from late research development through IND/CTA submissions and will have a significant and lasting impact on the company’s scientific direction and future success.

Key Responsibilities

• Strategic Program Leadership: Serve as a key strategic leader, partnering with the CSO to shape preclinical development strategy across the portfolio. Drive the strategic vision for advancing programs from late‑stage discovery through IND/CTA submission, ensuring alignment with corporate objectives and competitive positioning. Anticipate regulatory and scientific challenges, and proactively develop risk mitigation strategies to accelerate program timelines.
• Preclinical Study Oversight: Design, manage, and interpret pharmacology, PK/PD, and toxicology studies (GLP/non‑GLP) to support program advancement. Oversee CRO partnerships, protocol development, study monitoring, and regulatory documentation to deliver high‑quality nonclinical data packages.
• Cross‑Functional Integration: Lead cross‑functional collaboration with Bioanalytical, CMC, and Clinical teams to develop integrated nonclinical safety, translational science and CMC development strategies. Ensure seamless translation of preclinical findings into clinical development plans.
• Scientific Excellence & Team Development: Mentor and develop internal team members, building organizational capabilities in disease‑ and target‑relevant efficacy studies, PK/PD/biomarker strategies, and translational approaches across cardiovascular/metabolic and oncology therapeutic areas.

Required Qualifications

• PhD in Biology, Biochemistry, Biomedical Sciences, Pharmacology, Toxicology, Pharmaceutical Sciences, or related scientific discipline.
• 10+ years of relevant pharmaceutical/biotechnology industry experience, including 5+ years in a leadership capacity within preclinical pharmacology, toxicology, and/or DMPK.
• Demonstrated ability as program lead to advance programs from lead optimization to IND with complex biologics, such as antibodies, and/or antibody conjugates (ADCs, AOCs).
• Deep understanding of in vivo pharmacology and toxicology.
• Solid working knowledge in bioanalysis, PK/PD, and DMPK. Relevant experience with both biologics and small molecules is a strong plus.
• Experience delivering high‑quality preclinical/nonclinical data packages for drug candidate selection and IND‑enabling studies.
• Experience with cardiovascular/metabolic therapeutic area or oncology preferred.

Skills & Competencies

• Strong strategic thinking and scientific judgment with excellent problem‑solving capabilities.
• Excellent communication skills with the ability to distill complex scientific analyses into clear, actionable recommendations for diverse audiences.
• Strong interpersonal skills with the ability to motivate, influence, and lead cross‑functional teams in a matrixed environment.
• Demonstrated ability to work collaboratively and influence at all levels of the organization.
• Independent, self‑motivated leader with the ability to work in a fast‑paced, team‑based drug discovery and development environment.

About Salubris Biotherapeutics

Salubris Biotherapeutics, Inc. (or SalubrisBio) is a clinical‑stage biotechnology company dedicated to the discovery and global development of novel biologic therapeutics for the treatment of cancer, cardiovascular, and metabolic diseases. We are advancing a robust complex biologics pipeline including antibody‑drug‑conjugate and antibody‑fusion programs, with a commitment to transforming patient outcomes through scientific excellence and innovation.

We offer a competitive compensation package including base salary, performance bonus, equity participation, and comprehensive benefits.

SalubrisBio is an equal opportunity employer committed to diversity and inclusion in the workplace.

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