Scientist/Sr. Scientist - Large Molecule Biology
Eli Lilly and, Alexandria Bay, New York, United States
Overview
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We put people first and are looking for people determined to make life better for others. As a scientist in the Large Molecule Biology group, you will join a large and dynamic team focused on executing cutting-edge experiments in pharmaceutical sciences. You will execute experiments to support various research programs for identified targets, oversee portfolio programs with minimal direct oversight, and demonstrate laboratory expertise with biologic assays for drug development (mAb, ADC, and CD3 platforms). Assay development for specialized portfolio-related assays is also required. You will be encouraged to develop your own ideas and contribute them to the broader group, driving your own experiments and research while collaborating across the organization. Job Responsibilities
Design and implement studies to identify, evaluate, and advance therapeutic candidates through the drug development pipeline. Demonstrate laboratory expertise with biologic assays for drug development, specifically monoclonal antibodies (mAb), antibody-drug conjugates (ADC), and CD3 platforms. Manage the maintenance, culture, and passaging of multiple cell lines to support experimental objectives. Perform comprehensive functional assays and high-throughput screenings, including tumor cell signaling, internalization, cytotoxicity, effector function, and cytokine release assays to assess cellular responses. Conduct multi-parameter flow cytometry assays to determine binding interactions and accurately quantify receptor density across diverse cell populations. Conduct candidate evaluation in vitro (PK/PD, receptor occupancy, density, cytokine release) and in ex vivo assays (tumor isolation, analysis of blood cells). Develop, validate, and perform bioanalytical assays—including ELISA—to quantify proteins and antibodies relevant to experimental outcomes. Critically assess and monitor experimental procedures performed by third-party collaborators and vendors to ensure compliance with study protocols and quality standards. Work with the project leader and senior leaders to design and execute assays for molecule development. Present work to internal teams and summarize findings in preclinical reports; communicate results at project team meetings and assist in the preparation of presentations. Discuss results with both technical and non-technical personnel and collaborate across functional areas. Basic Requirements
Bachelor's degree in biological sciences or related field with 5+ years of experience, or Master’s degree with 2+ years of experience. Additional Skills/Preferences
Experience with mammalian cell culture Extensive expertise performing in vitro and ex vivo assays Strong data analysis skills with attention to detail Ability to design comprehensive experimental plans and execute them timely Deep expertise in cancer disease states (indications, mutational status, tumor cell drivers) Demonstrated experience collaborating across scientific disciplines to meet business goals Excellent communication and interpersonal skills Ability to succeed in a fast-paced environment, managing multiple projects with changing priorities and deadlines Lilly is dedicated to helping individuals with disabilities actively engage in the workforce and ensure equal opportunities when applying. If accommodation is needed to submit a resume for a Lilly position, please complete the accommodation request form at careers.lilly.com/us/en/workplace-accommodation for further assistance. This is for individuals requesting accommodation as part of the application process; other correspondence will not receive a response. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks and are open to all employees. Groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups. Actual compensation will depend on education, experience, skills, and geographic location. The anticipated wage for this position is $71,250 - $187,000. Full-time employees will be eligible for a company bonus (dependent, in part, on company and individual performance). Lilly offers a comprehensive benefits package, including eligibility for a 401(k) plan, pension, vacation benefits, medical/dental/vision and prescription drug benefits, flexible benefits, life insurance, leave benefits, and well-being programs. Lilly reserves the right to amend or modify compensation and benefit programs as needed. #WeAreLilly
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At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We put people first and are looking for people determined to make life better for others. As a scientist in the Large Molecule Biology group, you will join a large and dynamic team focused on executing cutting-edge experiments in pharmaceutical sciences. You will execute experiments to support various research programs for identified targets, oversee portfolio programs with minimal direct oversight, and demonstrate laboratory expertise with biologic assays for drug development (mAb, ADC, and CD3 platforms). Assay development for specialized portfolio-related assays is also required. You will be encouraged to develop your own ideas and contribute them to the broader group, driving your own experiments and research while collaborating across the organization. Job Responsibilities
Design and implement studies to identify, evaluate, and advance therapeutic candidates through the drug development pipeline. Demonstrate laboratory expertise with biologic assays for drug development, specifically monoclonal antibodies (mAb), antibody-drug conjugates (ADC), and CD3 platforms. Manage the maintenance, culture, and passaging of multiple cell lines to support experimental objectives. Perform comprehensive functional assays and high-throughput screenings, including tumor cell signaling, internalization, cytotoxicity, effector function, and cytokine release assays to assess cellular responses. Conduct multi-parameter flow cytometry assays to determine binding interactions and accurately quantify receptor density across diverse cell populations. Conduct candidate evaluation in vitro (PK/PD, receptor occupancy, density, cytokine release) and in ex vivo assays (tumor isolation, analysis of blood cells). Develop, validate, and perform bioanalytical assays—including ELISA—to quantify proteins and antibodies relevant to experimental outcomes. Critically assess and monitor experimental procedures performed by third-party collaborators and vendors to ensure compliance with study protocols and quality standards. Work with the project leader and senior leaders to design and execute assays for molecule development. Present work to internal teams and summarize findings in preclinical reports; communicate results at project team meetings and assist in the preparation of presentations. Discuss results with both technical and non-technical personnel and collaborate across functional areas. Basic Requirements
Bachelor's degree in biological sciences or related field with 5+ years of experience, or Master’s degree with 2+ years of experience. Additional Skills/Preferences
Experience with mammalian cell culture Extensive expertise performing in vitro and ex vivo assays Strong data analysis skills with attention to detail Ability to design comprehensive experimental plans and execute them timely Deep expertise in cancer disease states (indications, mutational status, tumor cell drivers) Demonstrated experience collaborating across scientific disciplines to meet business goals Excellent communication and interpersonal skills Ability to succeed in a fast-paced environment, managing multiple projects with changing priorities and deadlines Lilly is dedicated to helping individuals with disabilities actively engage in the workforce and ensure equal opportunities when applying. If accommodation is needed to submit a resume for a Lilly position, please complete the accommodation request form at careers.lilly.com/us/en/workplace-accommodation for further assistance. This is for individuals requesting accommodation as part of the application process; other correspondence will not receive a response. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks and are open to all employees. Groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups. Actual compensation will depend on education, experience, skills, and geographic location. The anticipated wage for this position is $71,250 - $187,000. Full-time employees will be eligible for a company bonus (dependent, in part, on company and individual performance). Lilly offers a comprehensive benefits package, including eligibility for a 401(k) plan, pension, vacation benefits, medical/dental/vision and prescription drug benefits, flexible benefits, life insurance, leave benefits, and well-being programs. Lilly reserves the right to amend or modify compensation and benefit programs as needed. #WeAreLilly
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