Scientist/Sr. Scientist - Large Molecule Biology
Eli Lilly and Company, New York, New York, us, 10261
Overview
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We put people first and strive to make life better for people around the world.
As a scientist in the Large Molecule Biology group, you will join a large and dynamic team focused on executing experiments on the cutting edge of pharmaceutical sciences. You will execute experiments to support various research programs for identified targets and oversee aspects of portfolio programs with minimal direct oversight. You will demonstrate laboratory expertise with biologic assays aimed at drug development (mAb, ADC and CD3 platforms) and develop specialized assays related to portfolio programs. You will be encouraged to develop your own ideas and contribute them to the broader group, driving your own experiments while collaborating extensively with the organization.
Job Responsibilities
Design and implement studies to identify, evaluate, and advance therapeutic candidates through the drug development pipeline.
Demonstrate laboratory expertise with biologic assays aimed at drug development, specifically utilizing monoclonal antibodies (mAb), antibody-drug conjugates (ADC), and CD3 platforms.
Manage the maintenance, culture, and passaging of multiple cell lines to support experimental objectives.
Perform comprehensive functional assays and high-throughput screenings, including tumor cell signaling, internalization, cytotoxicity, effector function and cytokine release assays, to assess cellular responses.
Conduct multi-parameter flow cytometry assays to determine binding interactions and accurately quantify receptor density across diverse cell populations.
Conduct candidate evaluation in both in vitro (PK/PD, receptor occupancy, density, cytokine release) and ex vivo assays (tumor isolation, analysis of blood cells).
Develop, validate, and perform bioanalytical assays—including ELISA—to precisely quantify proteins and antibodies relevant to experimental outcomes.
Critically assess and monitor experimental procedures performed by third-party collaborators and vendors to ensure compliance with study protocols and quality standards.
Work with the project leader and senior leader to design and execute assays for the development of the molecule.
Present work to internal teams and summarize findings in preclinical reports.
Communicate results at project team meetings and contribute to the coordination and preparation of presentations.
Discuss results with technical as well as non-technical personnel.
Work in cross-functional environments via extensive collaboration with other parts of the organization.
Basic Requirements
Bachelors degree in biological sciences or related scientific field with 5+ years of experience or Master’s in biological sciences or related scientific field with 2+ years of experience.
Additional Skills/Preferences
Experience with mammalian cell culture
Extensive expertise performing in vitro and ex vivo assays
Strong data analysis skills with attention to detail
Ability to design comprehensive experimental plans and carry out in a timely fashion
Deep expertise in cancer disease states (indications, mutational status, tumor cell drivers)
Demonstrated experience in working collaboratively across various scientific disciplines to meet end goals of business
Excellent communication and interpersonal skills
Demonstrated ability to succeed in a fast-paced environment, working on multiple projects with constantly changing priorities and deadlines
EEO and Accommodations Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( https://careers.lilly.com/us/en/workplace-accommodation ) for further assistance. This is for individuals to request an accommodation as part of the application process; any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.
Compensation and Benefits Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is
$71,250 - $187,000
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities). Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
#WeAreLilly
#J-18808-Ljbffr
As a scientist in the Large Molecule Biology group, you will join a large and dynamic team focused on executing experiments on the cutting edge of pharmaceutical sciences. You will execute experiments to support various research programs for identified targets and oversee aspects of portfolio programs with minimal direct oversight. You will demonstrate laboratory expertise with biologic assays aimed at drug development (mAb, ADC and CD3 platforms) and develop specialized assays related to portfolio programs. You will be encouraged to develop your own ideas and contribute them to the broader group, driving your own experiments while collaborating extensively with the organization.
Job Responsibilities
Design and implement studies to identify, evaluate, and advance therapeutic candidates through the drug development pipeline.
Demonstrate laboratory expertise with biologic assays aimed at drug development, specifically utilizing monoclonal antibodies (mAb), antibody-drug conjugates (ADC), and CD3 platforms.
Manage the maintenance, culture, and passaging of multiple cell lines to support experimental objectives.
Perform comprehensive functional assays and high-throughput screenings, including tumor cell signaling, internalization, cytotoxicity, effector function and cytokine release assays, to assess cellular responses.
Conduct multi-parameter flow cytometry assays to determine binding interactions and accurately quantify receptor density across diverse cell populations.
Conduct candidate evaluation in both in vitro (PK/PD, receptor occupancy, density, cytokine release) and ex vivo assays (tumor isolation, analysis of blood cells).
Develop, validate, and perform bioanalytical assays—including ELISA—to precisely quantify proteins and antibodies relevant to experimental outcomes.
Critically assess and monitor experimental procedures performed by third-party collaborators and vendors to ensure compliance with study protocols and quality standards.
Work with the project leader and senior leader to design and execute assays for the development of the molecule.
Present work to internal teams and summarize findings in preclinical reports.
Communicate results at project team meetings and contribute to the coordination and preparation of presentations.
Discuss results with technical as well as non-technical personnel.
Work in cross-functional environments via extensive collaboration with other parts of the organization.
Basic Requirements
Bachelors degree in biological sciences or related scientific field with 5+ years of experience or Master’s in biological sciences or related scientific field with 2+ years of experience.
Additional Skills/Preferences
Experience with mammalian cell culture
Extensive expertise performing in vitro and ex vivo assays
Strong data analysis skills with attention to detail
Ability to design comprehensive experimental plans and carry out in a timely fashion
Deep expertise in cancer disease states (indications, mutational status, tumor cell drivers)
Demonstrated experience in working collaboratively across various scientific disciplines to meet end goals of business
Excellent communication and interpersonal skills
Demonstrated ability to succeed in a fast-paced environment, working on multiple projects with constantly changing priorities and deadlines
EEO and Accommodations Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( https://careers.lilly.com/us/en/workplace-accommodation ) for further assistance. This is for individuals to request an accommodation as part of the application process; any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.
Compensation and Benefits Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is
$71,250 - $187,000
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities). Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
#WeAreLilly
#J-18808-Ljbffr