Sr. Manager/Associate Director, Process Chemistry
Corvus Pharmaceuticals, Inc., San Francisco
Department/Group:Chemistry
Location:South San Francisco, CA
Position Type:Full time
Role and Responsibilities
- Independently design synthetic strategies and use those strategies to synthesize and characterize precursor compounds, starting materials, intermediates, reference compounds, and new chemical entities
- Scale up and process development of small molecules across early through late-stage phases
- Design and conduct control strategies for drug substance manufacturing including impurity identification and synthesis, and fate and purge experiments
- Purify and characterize molecules with standard analytical techniques (e.g. HPLC, LCMS, NMR)
- Collaborate with cross functional teams of product development, QA, analytical and formulations.
- Work with contract organizations and support technology transfer
- Perform research and/or development in collaboration with others in chemistry and biology; make detailed observations and analyze data.
- Prepare batch records, technical reports, summaries, protocols and quantitative analyses
- Write and review manuscripts for publication
- Provide support in corporate research and development of patent applications
- Develop strategies to ensure effective achievement of scientific objectives
- Uses skills to contribute to development of company objectives and principles and to achieve goals in creative and effective ways
- Exercises independent judgment in selecting methods, techniques and evaluation criteria for obtaining results
Qualifications and Education Requirements
- PhD in Chemistry plus 5+ years of related experience in pharmaceutical or biotechnology industry or equivalent.
- Demonstrated expertise and hands‑on experience in synthetic organic chemistry process development and manufacturing.
- Knowledge of regulatory (ICH, USP etc.) standards.
- Experience working with CRO/CDMO partners for drug substance manufacturing.
- Must possess expert knowledge of scientific principles and concepts.
- A solid understanding of modern analytical techniques (NMR, HPLC, MS)
- Excellent verbal and written communication skills and the ability to collaborate effectively within a multidisciplinary team
Preferred Skills
- Able to manage outside vendor collaborations
- Flexibility and willingness to solve problems that fall outside of immediate area of expertise
- Work independently in an interdisciplinary, fast‑paced, often changing environment.
- Committed to the values of integrity, accountability, transparency, and drive.