Senior Director, US Commercial Strategy & Operations Planning

Senior Director, US Commercial Strategy and Operations Planning

Conshohocken, PA

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR‑β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

About Us

Madrigal is a biopharmaceutical company focused on developing novel therapeutics for non‑alcoholic steatohepatitis (NASH), also known as metabolic dysfunction-associated steatohepatitis (MASH). Our first therapy, Rezdiffra , has received accelerated approval from the U.S. Food and Drug Administration (FDA) for treating adults with NASH and moderate to advanced liver fibrosis (consistent with stages F2 to F3). Rezdiffra is also being evaluated in a Phase 3 trial for treating NASH with compensated cirrhosis.

Position Overview

We are seeking a dynamic and experienced Senior Director of US Commercial Strategy and Operations Planning to join our CS&O leadership team. This role combines strategic planning with operational oversight with cross‑functional leadership coordination to ensure the seamless execution of key US commercial initiatives. The successful candidate will act as a trusted advisor to the commercial team, driving strategic initiatives, aligning cross‑functional teams, and optimizing operational excellence at Madrigal. The role also focuses on fostering a culture of innovation and monitoring emerging trends to maintain competitive advantage.

Key Responsibilities

US Key Strategic Initiatives

• Collaborate with commercial leadership to develop and refine key strategic initiatives that support market expansion and revenue growth.
• Act as a trusted advisor to the Head of Commercial Strategy & Operations, providing thought leadership and operational support to align initiatives with business objectives.
• Analyze market trends, competitive landscapes, and customer needs to identify opportunities and mitigate risks.
• Monitor the execution of key initiatives, ensuring accountability, and provide regular updates to senior leadership.
• Prepare briefing materials, reports, and presentations for executive leadership and board meetings as needed.

US Operational Planning and Execution

• Consolidate and track operational plans to support strategic goals, ensuring alignment with sales, marketing, market access, and medical affairs.
• Oversee Commercial Strategy & Operations governance framework, including managing governance committees, cross‑functional pods, and the CS&O program management office.
• Partner with finance to develop and manage budgets and ensure resource optimization.
• Facilitate the execution of strategic priorities by coordinating across functional teams and removing barriers to success.
• Serve as a member of the Enterprise and Commercial Operations Councils to support optimal coordination, planning and execution across the organization.

Innovation and Continuous Improvement

• Champion knowledge‑sharing practices to bridge gaps and improve integration between commercial functions.
• Encourage and support innovative ideas and initiatives within teams to improve processes, strategies, and outcomes.
• Identify and address operational inefficiencies, driving continuous improvement across commercial functions.
• Stay ahead of industry trends, technologies, and regulatory changes to proactively adapt strategies and operations.
• Develop platforms and forums for knowledge sharing, creative problem‑solving, and fostering innovation across teams.
• Foster team culture and engagement through targeted initiatives including Town Halls, off‑sites and recognition programs.

Qualifications

• Education: Bachelor’s degree in Business, Life Sciences, or a related field required; MBA or advanced degree preferred.
• Experience:
  • Minimum of 12‑15 years of experience in commercial operations, commercial strategy & insights, commercial data and analytics, or a related field, with a significant portion in the pharmaceutical or biotechnology industry.
  • Proven track record of leading successful product launches or high growth products, high‑impact initiatives, and cross‑functional teams in a complex, regulated environment.
• Skills:
  • Strong analytical and strategic thinking skills with a results‑driven mindset.
  • Strong organizational and project management skills.
  • Exceptional leadership, communication, and influencing abilities.
  • Expertise in resource planning, performance management, and operational execution.
  • Familiarity with CRM systems, data analytics tools, and industry‑specific platforms.

Key Competencies

• Strategic vision and ability to translate complex concepts into actionable plans.
• Exceptional organizational and problem‑solving skills with the ability to manage ambiguity.
• High emotional intelligence and aptitude for building strong relationships across diverse teams.
• Proven ability to manage competing priorities while maintaining a focus on organizational goals.
• Strong collaborative mindset with the ability to integrate and align multiple commercial functions.
• Embraces innovation as a core value, encouraging teams to think creatively and explore transformative opportunities to drive growth and efficiency.
• Business Owner Mindset: Demonstrates accountability, ownership, and a proactive approach to achieving results, while consistently seeking ways to innovate and deliver value.

Benefits and Compensation

Madrigal’s Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. Base salary for this position is estimated at $250,000–$315,000 per year. As a full‑time employee you will receive equity and comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (traditional, Roth, and employer match) in accordance with applicable plans. Additional voluntary benefits include supplemental life insurance, legal services, and other offerings. Mental health benefits are provided through our Employee Assistance Program.

Equal Employment Opportunity

Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex, gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law.

Application Information

Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site.

We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact

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