Sr. Director, US Team Lead Sigvotatug Vedotin

Locations

• United States - Massachusetts - Cambridge
• United States - Washington – Bothell
• United States - Pennsylvania - Collegeville
• United States - New York - New York City

We’re in relentless pursuit of breakthroughs that change patients’ lives. We innovate every day to make the world a healthier place.

Overview

To fully realize Pfizer’s purpose – Breakthroughs that change patients’ lives – we have established a clear set of expectations regarding “what” we need to achieve for patients and “how” we will go about achieving those goals.

Pfizer offers competitive compensation and benefits programs designed to meet the diverse needs of our colleagues.

At Pfizer Oncology, our purpose is to Outdo Cancer by delivering transformative medicines that have the potential to meaningfully change outcomes for patients. Pfizer Oncology’s industry‑leading pipeline spans breast, genitourinary (GU), hematology, gastroenterology, and thoracic therapeutic areas, reflecting both scientific depth and sustained investment in areas of high unmet need.

The US Precision Medicine/Thoracic Franchise is positioned for significant growth, supported by a differentiated thoracic portfolio that includes Sigvotatug Vedotin (SGN‑B6A / IB6), an investigational antibody‑drug conjugate (ADC) under development for the treatment of non‑small cell lung cancer (NSCLC). Sigvotatug Vedotin represents a potential next‑generation approach within thoracic oncology, reinforcing Pfizer’s commitment to advancing precision‑based strategies and expanding therapeutic options in a highly competitive and evolving landscape. This asset, alongside a strong future thoracic pipeline, underscores the franchise’s long‑term strategic importance to Pfizer Oncology.

Role Summary

The role is ideally suited for an experienced, enterprise‑minded leader with deep US commercial marketing expertise and a strong track record of operating at scale. The successful candidate will lead and develop a high‑performing team of marketers while partnering closely with Global Marketing, Medical, Market Access, and the broader US Precision Medicine/Lung portfolio team to deliver a fully integrated, insight‑driven go‑to‑market strategy that advances patient outcomes and drives sustainable franchise growth.

Role Responsibilities

• Provide direct leadership and mentorship to a team of director and senior manager‑level marketers, cultivating a high‑performance culture and unlocking the full potential of the brand.
• Take comprehensive responsibility for all U.S. pre‑launch and launch initiatives for Sigvotatug Vedotin, ensuring thorough preparation and seamless execution.
• Shape and implement the U.S. go‑to‑market strategy collaboratively, working closely with Global Marketing and Market Access teams to optimize impact.
• Guide the co‑development of best‑in‑class launch materials for healthcare professionals (HCPs) with Global Marketing, ensuring Sigvotatug Vedotin is optimally positioned for success amid competitive dynamics.
• Identify, assess, and execute strategic growth opportunities for the brand through detailed planning and data‑informed decisions.
• Lead the creation and delivery of annual strategic and tactical plans designed to support both immediate and long‑term HCP and patient objectives, grounded in key customer insights.
• Continuously measure and enhance the effectiveness of HCP marketing activities, generating actionable insights to fuel ongoing brand improvement.
• Oversee all processes related to the brand’s annual operating plan and latest estimates, maintaining strong alignment with overall business objectives.
• Collaborate with Medical, Market Analytics, Field Force, and prescribers to extract essential customer insights and translate them into robust commercial strategies.
• Manage the brand’s advertising and promotion (A&P) budget and direct agency partnerships to guarantee operational excellence and financial stewardship.

Basic Qualifications

• Educational Background: Bachelor’s degree with at least 12+ years of progressive pharmaceutical industry experience, or a Master’s degree with a minimum of 10+ years’ experience, or a Ph.D./PharmD with at least 7+ years of relevant experience.
• Leadership Experience: Minimum of 5 years leading and managing marketing teams across all levels, from Manager to Director. Proven commitment to fostering team engagement, cultivating a positive and collaborative culture, and mentoring and developing talent.
• Product Launch Expertise: Demonstrated track record of success in U.S. product launches and lifecycle management. Prior experience with both U.S. and/or global product launches and lifecycle strategies is highly valued.
• Cross‑Functional Collaboration: Extensive experience collaborating and interfacing with field sales, medical affairs, regulatory, and supply chain teams, ensuring seamless execution across all stages of the product lifecycle.
• Strategic and Analytical Skills: Outstanding strategic thinking and problem‑solving abilities, including the capacity to evaluate complex business opportunities, make informed trade‑off decisions, and build compelling business cases to drive growth.
• Stakeholder Management: Ability to work autonomously and effectively engage senior‑level stakeholders, exercising sound judgment on escalation and ensuring strong alignment with organizational objectives.
• Communication and Presentation: Superior oral and written communication skills with a proven ability to deliver clear, persuasive presentations and influence diverse audiences.
• Project and Team Leadership: Exceptional project management capabilities with a history of successfully leading large, diverse, cross‑functional teams to deliver results on multiple, high‑priority initiatives in fast‑paced, deadline‑driven settings.
• Leadership Impact: Demonstrates a breadth of diverse leadership experience, including influencing and collaborating with peers, coaching and developing others, and effectively overseeing and guiding the work of colleagues to achieve meaningful business outcomes.
• Results Orientation: Proven ability to manage and deliver on multiple, complex, and competing projects simultaneously. Highly self‑motivated, driven by achieving results, and adept at organizing and prioritizing numerous projects over time.

Preferred Qualifications

• MBA or other advanced degrees are desirable.
• Previous US Marketing experience preferred.
• Oncology experience preferred but not required.

Non‑Standard Work Schedule, Travel or Environment Requirements

• Ability to travel domestically and internationally as needed for congresses and customer engagements. Expected domestic travel 20%.

Other Job Details

• Last Date to Apply for Job: March 22nd, 2026
• Additional Location Information: New York, NY; Collegeville, PA; Cambridge, MA; Bothell, WA; Lake Forest, IL
• Eligible for Relocation Package: No
• Relocation assistance may be available based on business needs and/or eligibility.

The annual base salary for this position ranges from $230,900.00 to $366,400.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 25.0% of the base salary and eligibility to participate in our share‑based long‑term incentive program.

We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E‑Verify employer. This position requires permanent work authorization in the United States.

Accessibility

Pfizer endeavors to make accessible to all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process and/or interviewing, please email This is to be used solely for accommodation requests with respect to the accessibility of our website, online application process and/or interviewing. Requests for any other reason will not be returned.

Breakthroughs that change patients’ lives

Research confirms what intuition tells us: that purpose-driven companies perform better, are more innovative, attract and retain the best people, and know how to unleash the power of those people.

Pfizer’s purpose—Breakthroughs that change patients' lives—fuels everything we do and reflects our passion for building on our legacy as one of the greatest contributors of good to the world.

Each word in our purpose has meaning and reflects the value we strive to bring to patients and society:

“Breakthroughs” - These are the innovations, scientific and commercial, that we seek to deliver every day. All colleagues, regardless of role, level or location, strive for breakthroughs every day.

“Change” - We want to do more than simply improve patients’ medical conditions; we want to dramatically change their lives for the better.

“Patients’ lives” - We consider not only patients, but everyone they touch—including their families, caregivers, and friends—and everything they love to do. It’s an intentionally holistic view.

Our purpose ensures that patients remain at the center of all we do. We live our purpose by sourcing the best science in the world; partnering with others in the healthcare system to improve access to our medicines; using digital technologies to enhance our drug discovery and development, as well as patient outcomes; and leading the conversation to advocate for pro-innovation/pro-patient policies.

Every decision we make and every action we take is done with the patient in mind—and to nurture an environment where breakthroughs can thrive.

Our Values

To fully realize Pfizer’s purpose, we have established a clear set of expectations regarding “what” we need to achieve for patients and “how” we will go about achieving those goals.

The “how” is represented by four simple, powerful values—courage, excellence, equity, and joy—that define our company and our culture.

Courage: Breakthroughs start by challenging convention, especially in the face of uncertainty or adversity. This happens when we think big, speak up, and are decisive.

Excellence: We can only change patients’ lives when we perform at our best together. This happens when we focus on what matters, agree who does what, and measure our outcomes.

Equity: We believe that every person deserves to be seen, heard, and cared for. This happens when we are inclusive, act with integrity, and reduce healthcare disparities.

Joy: We give ourselves to our work, but it also gives to us. We find joy when we take pride, recognize one another, and have fun.

Benefits at Pfizer

Pfizer offers competitive compensation and benefits programs designed to meet the diverse needs of our colleagues. Our Pay for Performance Philosophy and Practices reward colleagues based on the contributions they make to our business.

Our Competitive Benefits Programs help our colleagues by:

• Promoting Health and Wellness to help colleagues maintain and improve their physical and mental wellbeing. Pfizer offerings include health and disability insurance, preventative health programs, medical screenings, free or reduced‑cost vaccinations, discounts on Pfizer products, mental health support, nutrition and fitness counseling and more.
• Strengthening Colleagues’ Financial Security by providing company contributions to retirement plans, life insurance and financial planning education to help colleagues achieve their financial goals.
• Providing Benefits and Time off for the Moments that Matter to ensure Pfizer colleagues have the time away from the office to recharge, recover and return to work as the best version of themselves. Vacation, Holiday time and Sick time are just the beginning, with a 12 week parental leave policy for both parents of a new born, 10 day of caregiver leave for those times when your family needs you whether it’s a child, spouse or parent, bereavement leave, and additional country‑specific programs.
• And so much more , depending on your country and site, Pfizer offers childcare facilities or discount programs, on‑site health and/or fitness centers , movement and mindfulness solutions, “Log in for your Day” work flexibility and so much more.

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