Director, Translational Medicine Lead, Hematology

Introduction to Role:

Within Hematology R&D, we are committed to advancing science to deliver life‑changing medicines to patients most in need. With a combination‑focused pipeline that exploits the power of six scientific platforms (Immuno‑Oncology, Tumor Drivers and Resistance, DNA Damage Response, Antibody‑drug Conjugates, Cell Therapy and Epigenetics) to help address unmet clinical needs in a host of hematological cancers, we are motivated by a dedication to the scientific discovery and collaboration that will one day help eliminate cancer as a cause of death. This unit has responsibility for the value chain from discovery through to late‑stage development, enabling rapid acceleration of promising early‑stage assets and life‑cycle management programmes.

The Hematology Research and Development (R&D) team is accountable for all drug development activities in hematology research from first‑in‑man studies, all the way to late‑stage trials leading to drug approval by regulatory agencies (Phase 1, 2, and 3 trials). The team strives to deliver compelling preclinical, clinical, and translational data packages providing confidence in the dosing strategy, tolerability profile, and therapeutic efficacy of our candidate drugs to support investment in late‑stage clinical development, leading to drug approval.

We are seeking a Director, Translational Medicine Lead in Haematology R&D to join a world class Haematology R&D unit. In this role you will be accountable for delivery of robust, scientifically‑driven biomarkers in drug discovery and development programmes for hematology programmes. You will have the opportunity to impact an industry‑leading portfolio of hematology programmes from inception through to life‑cycle management for marketed drugs.

Accountabilities:

• In partnership with the Translational Medicine team, lead the implementation of strategic vision that enables target identification, indication selection, early indication of biological activity and patient stratification/selection in Haematology.
• Deliver biomarkers for clinical studies based on the best available science and technologies.
• Generate biomarker data to guide indication selection and identification of targeted patient populations.
• Measure target engagement reliably and quantifiably to inform clinical decisions for selecting therapeutically relevant doses and schedules.
• Understand key cancer pathway interactions and feedback mechanisms in clinical samples to guide rational drug combinations.
• Define novel mechanisms of resistance targeted therapies by studying tumours at relapse.
• Collaborate with broader Oncology Research and product development teams to facilitate appropriate incorporation of Translational Medicine strategies for molecules in early phases of development in Oncology.
• Collaborate with clinical development and operations teams to implement translational strategy, sample collections and analyses in clinical studies related to Haematology.
• Collaborating with the clinical development team to design and execute appropriate phase 1/2a study(s) to generate FIH safety, PK, PD, PK/PD, biomarker or efficacy/PoC data to support continued clinical development or no‑go for programme.
• Manage internal and external research collaborations in areas of clinical technologies and oncology translational research.
• Ensure complex clinical assays developed and validated internally or externally are fit for purpose.
• Contribute to and ensure the quality of Translational Medicine clinical study reports, data reviews and interpretations, presentations, scientific publications and recommendations to development teams and management.

Minimum Qualifications:

• PhD and /or MD with experience in oncology drug development required.
• Oncology training is required, preferably board‑certified or board‑eligible in Oncology and/or Haematology.
• 5+ years of experience in drug development in pharmaceutical or biotech industries.
• In‑depth knowledge of Haematology disease‑area biology and translational science, ideally with expertise in myeloma, leukaemia and lymphoma.
• Experience with T cell engagers, antibody‑drug conjugates or cell therapy modalities is preferred.
• Proven communication, presentation and influencing skills.
• Highly developed problem‑solving and risk management skills.
• Ability to drive, manage, execute and deliver results for complex multi‑functional projects.
• Highly developed collaborative working skills.
• Ability to act as an external ambassador and to influence external organisations to enhance the image and reputation of AstraZeneca.
• Proven ability to motivate and develop others.

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small can be the start of something big. Delivering life‑changing medicines is about being ambitious – finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio‑pharmaceutical company can be. This means we’re opening new ways to work, groundbreaking methods, and bringing unexpected teams together. Interested? Come and join our journey.

So,what’snext?

Are you ready to bring new insights and fresh thinking to the table? Brilliant! We have one seat available, and we hope it’s yours.

The annual base pay for this position ranges from $175,498.40 – $263,247.60 USD. Hourly and salaried non‑exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualised factors, including market location, job‑related knowledge, skills and experience. In addition, our positions offer a short‑term incentive bonus opportunity; eligibility to participate in our equity‑based long‑term incentive programme (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered include a qualified retirement programme (401(k) plan); paid vacation and holidays; paid leaves; and health benefits including medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at‑will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation programme) at any time, including for reasons related to individual performance, company or individual department/team performance and market factors.

Date Posted 09‑Mar‑2026

Closing Date 22‑Mar‑2026

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.

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