Director/Sr. Director/Exec. Director Computational Chemistry, Advanced Molecular
SupportFinity™, San Francisco, CA, United States
Director/Sr. Director/Exec. Director Computational Chemistry, Advanced Molecular Design
Eli Lilly and Company | Posted Mar 13 | Full-time | Unknown
Overview At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. We focus on discovering, developing and delivering medicines that help people live longer, healthier, more active lives. Our Small Molecule Discovery group is purpose-built to create molecules that make life better for people, using cutting edge science to unlock new approaches that can treat diseases with poor treatment options. We continually challenge ourselves to deliver breakthrough efficacy with the highest safety margins, using a culture that empowers innovative problem solving through open collaboration.
Position Summary Lilly’s Advanced Molecular Design (AMD) team is responsible for small molecule lead optimization with rapid progress toward new clinical candidates. We seek experienced drug discovery experts who will apply modern computational chemistry tools in close collaboration with medicinal chemistry and structural biology teams. The ideal candidate will be passionate about a holistic approach to drug discovery, studying all aspects of molecular design through to clinical trials. Interactive communication and collaboration are essential to fulfill this leadership role within Lilly Small Molecule Discovery.
Responsibilities
Structure-based design efforts for lead/late-stage optimization of small molecule therapeutics across various therapeutic areas.
Prioritize medicinal chemistry efforts through critical analysis and effective decision-making, leading to highly focused work and rapid progress.
Ensure timely delivery of data and results to project teams to enable rapid iterative design cycles.
Maintain critical timelines and set team expectations for efficient delivery of clinical candidates.
Contribute to decision-making at higher levels, including prioritization of the overall small-molecule discovery portfolio.
Work closely with other AMD and therapeutic area leaders to move the portfolio of molecules from leads to quality drug candidates with strong potential to become breakthrough drugs.
Contribute to ongoing evaluation of external technologies and related business development opportunities.
Basic Requirements
PhD in Chemistry, Biophysics, or related discipline with 6–15 years of drug discovery research experience.
Additional Preferences
A deep scientific background in computational chemistry technology to guide compound optimization for medicinal chemists.
Proven ability to collaborate across disciplines to achieve project goals and timelines.
Proactive and effective collaboration with medicinal chemists, structural biologists, and other disciplines to achieve project goals and timelines.
Commitment to mentoring early career computational chemists.
Strong core desire to help patients in need.
Proven track record of success in drug discovery.
Deep thinking that leads to creative hypotheses for the optimization of lead series across multiple projects.
Desire to establish a deeper understanding of all aspects of drug discovery, including small molecule–protein interactions, ADME, and toxicological considerations.
Highly engaged approach to solving challenging problems in discovery.
Desire to stay up to date with the latest industry developments and novel techniques, including AI and machine learning models.
Deep knowledge of lead optimization using structure-based design and other aspects of computational chemistry.
Agility and adaptability to change research priorities as necessary for success.
Physical Demands/Travel The physical demands of this job are consistent with an office environment. Travel may be required.
Work Environment This is an onsite position located in one of the established Lilly med chem sites in San Francisco, California or Louisville, Colorado.
Compensation & Benefits Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $193,500 – $338,800 per annum. Full‑time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). Lilly offers a comprehensive benefits program including a 401(k) plan, pension, vacation benefits, medical, dental, vision and prescription drug benefits, flexible benefits, life insurance, leave of absence benefits, and well‑being benefits such as employee assistance program, fitness benefits, and employee clubs and activities.
Equal Employment Opportunity Lilly is a proud EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
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Overview At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. We focus on discovering, developing and delivering medicines that help people live longer, healthier, more active lives. Our Small Molecule Discovery group is purpose-built to create molecules that make life better for people, using cutting edge science to unlock new approaches that can treat diseases with poor treatment options. We continually challenge ourselves to deliver breakthrough efficacy with the highest safety margins, using a culture that empowers innovative problem solving through open collaboration.
Position Summary Lilly’s Advanced Molecular Design (AMD) team is responsible for small molecule lead optimization with rapid progress toward new clinical candidates. We seek experienced drug discovery experts who will apply modern computational chemistry tools in close collaboration with medicinal chemistry and structural biology teams. The ideal candidate will be passionate about a holistic approach to drug discovery, studying all aspects of molecular design through to clinical trials. Interactive communication and collaboration are essential to fulfill this leadership role within Lilly Small Molecule Discovery.
Responsibilities
Structure-based design efforts for lead/late-stage optimization of small molecule therapeutics across various therapeutic areas.
Prioritize medicinal chemistry efforts through critical analysis and effective decision-making, leading to highly focused work and rapid progress.
Ensure timely delivery of data and results to project teams to enable rapid iterative design cycles.
Maintain critical timelines and set team expectations for efficient delivery of clinical candidates.
Contribute to decision-making at higher levels, including prioritization of the overall small-molecule discovery portfolio.
Work closely with other AMD and therapeutic area leaders to move the portfolio of molecules from leads to quality drug candidates with strong potential to become breakthrough drugs.
Contribute to ongoing evaluation of external technologies and related business development opportunities.
Basic Requirements
PhD in Chemistry, Biophysics, or related discipline with 6–15 years of drug discovery research experience.
Additional Preferences
A deep scientific background in computational chemistry technology to guide compound optimization for medicinal chemists.
Proven ability to collaborate across disciplines to achieve project goals and timelines.
Proactive and effective collaboration with medicinal chemists, structural biologists, and other disciplines to achieve project goals and timelines.
Commitment to mentoring early career computational chemists.
Strong core desire to help patients in need.
Proven track record of success in drug discovery.
Deep thinking that leads to creative hypotheses for the optimization of lead series across multiple projects.
Desire to establish a deeper understanding of all aspects of drug discovery, including small molecule–protein interactions, ADME, and toxicological considerations.
Highly engaged approach to solving challenging problems in discovery.
Desire to stay up to date with the latest industry developments and novel techniques, including AI and machine learning models.
Deep knowledge of lead optimization using structure-based design and other aspects of computational chemistry.
Agility and adaptability to change research priorities as necessary for success.
Physical Demands/Travel The physical demands of this job are consistent with an office environment. Travel may be required.
Work Environment This is an onsite position located in one of the established Lilly med chem sites in San Francisco, California or Louisville, Colorado.
Compensation & Benefits Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $193,500 – $338,800 per annum. Full‑time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). Lilly offers a comprehensive benefits program including a 401(k) plan, pension, vacation benefits, medical, dental, vision and prescription drug benefits, flexible benefits, life insurance, leave of absence benefits, and well‑being benefits such as employee assistance program, fitness benefits, and employee clubs and activities.
Equal Employment Opportunity Lilly is a proud EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
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