Senior Specialist, Genetic Analysis
Memorial Sloan, New York, NY, United States
The people of Memorial Sloan Kettering Cancer Center (MSK) are united by a singular mission: ending cancer for life. Our specialized care teams provide personalized, compassionate, expert care to patients of all ages. Informed by basic research done at our Sloan Kettering Institute, scientists across MSK collaborate to conduct innovative translational and clinical research that is driving a revolution in our understanding of cancer as a disease and improving the ability to prevent, diagnose, and treat it. MSK is dedicated to training the next generation of scientists and clinicians, who go on to pursue our mission at MSK and around the globe.
Role Overview
Interpret and classify germline genetic variants identified through clinical next-generation sequencing (NGS) using AMP / ACMG guidelines with established genomic databases. Review NGS pipeline output for sample quality, accuracy, relevant genetic history, and sequencing artifacts; initiate confirmatory testing as needed. Collaborate closely with molecular pathologists, geneticists, genetic counselors, and bioinformatics analysts to draft and finalize clinical reports. Support laboratory operations under supervision by contributing to workflow optimization, SOP development, and NYSDOH validation submissions. Train, mentor, and assess competency of peer analysts, new, and rotating staff in germline variant interpretation. Participate in translational research initiatives, data sharing efforts (e.g., ClinVar), and quality improvement projects. Assist with evaluating, testing, and integrating new variant analytical tools and databases into clinical workflows. Support regulatory inspections, as needed, to ensure clinical laboratory compliance with data security, clinical documentation, and HIPAA standards. Key Qualifications
Master's degree in Human Genetics, Genetics, Genetic Counseling, Cancer Biology, or Molecular Biology (required). PhD in Human Genetics, Genetics, Cancer Biology, or Molecular Biology is preferred. Comprehensive knowledge and demonstrated proficiency in interpreting germline variants in a clinical laboratory and/or cancer genetics setting. Strong foundation in human genetics and the molecular biology of cancer susceptibility genes. Experience with germline genetic databases and cancer predisposition variant analysis tools. Demonstrated ability to critically evaluate scientific literature and apply findings to clinical variant interpretation. Core Skills
Advanced Analytical & Critical Thinking – Interprets complex genomic data and applies evidence-based reasoning to variant analysis. Molecular & Germline Genetics Knowledge – Experience with molecular lab workflows, germline cancer genetics, and clinical laboratory regulations. Genomic & Bioinformatics Knowledge – Experience with NGS, Sanger Sequencing, MLPA data interpretation, relevant clinical analysis tools, and bioinformatics software/databases. Expert Scientific Literacy – Ability to critically read, interpret, and apply findings from scientific literature to clinical practice and variant curation. Communication & Knowledge Sharing – Excellent written, verbal, and presentation skills; ability to train and collaborate effectively across multidisciplinary teams. Additional Information
Location: Schwartz Building, 1250 First Avenue, New York, NY Schedule: Monday – Friday, 9 am – 5 pm Reports to: Pathology and Laboratory Medicine Supervisor, Molecular Diagnostic Lab Helpful Links
Compensation Philosophy Benefits Pay Range: $83,800.00 – $134,000.00 FSLA Status: Exempt Closing: At MSK, we believe in fair, competitive pay that reflects your job, experience, and skills. MSK is an equal opportunity and affirmative action employer committed to diversity and inclusion in all aspects of recruiting and employment. All qualified individuals are encouraged to apply and will receive consideration without regard to race, color, gender, gender identity or expression, sexual orientation, national origin, age, religion, creed, disability, veteran status or any other factor which cannot lawfully be used as a basis for an employment decision. Federal law requires employers to provide reasonable accommodation to qualified individuals with disabilities. Please tell us if you require a reasonable accommodation to apply for a job or to perform your job. Examples of reasonable accommodation include making a change to the application process or work procedures, providing documents in an alternate format, using a sign language interpreter, or using specialized equipment.
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Interpret and classify germline genetic variants identified through clinical next-generation sequencing (NGS) using AMP / ACMG guidelines with established genomic databases. Review NGS pipeline output for sample quality, accuracy, relevant genetic history, and sequencing artifacts; initiate confirmatory testing as needed. Collaborate closely with molecular pathologists, geneticists, genetic counselors, and bioinformatics analysts to draft and finalize clinical reports. Support laboratory operations under supervision by contributing to workflow optimization, SOP development, and NYSDOH validation submissions. Train, mentor, and assess competency of peer analysts, new, and rotating staff in germline variant interpretation. Participate in translational research initiatives, data sharing efforts (e.g., ClinVar), and quality improvement projects. Assist with evaluating, testing, and integrating new variant analytical tools and databases into clinical workflows. Support regulatory inspections, as needed, to ensure clinical laboratory compliance with data security, clinical documentation, and HIPAA standards. Key Qualifications
Master's degree in Human Genetics, Genetics, Genetic Counseling, Cancer Biology, or Molecular Biology (required). PhD in Human Genetics, Genetics, Cancer Biology, or Molecular Biology is preferred. Comprehensive knowledge and demonstrated proficiency in interpreting germline variants in a clinical laboratory and/or cancer genetics setting. Strong foundation in human genetics and the molecular biology of cancer susceptibility genes. Experience with germline genetic databases and cancer predisposition variant analysis tools. Demonstrated ability to critically evaluate scientific literature and apply findings to clinical variant interpretation. Core Skills
Advanced Analytical & Critical Thinking – Interprets complex genomic data and applies evidence-based reasoning to variant analysis. Molecular & Germline Genetics Knowledge – Experience with molecular lab workflows, germline cancer genetics, and clinical laboratory regulations. Genomic & Bioinformatics Knowledge – Experience with NGS, Sanger Sequencing, MLPA data interpretation, relevant clinical analysis tools, and bioinformatics software/databases. Expert Scientific Literacy – Ability to critically read, interpret, and apply findings from scientific literature to clinical practice and variant curation. Communication & Knowledge Sharing – Excellent written, verbal, and presentation skills; ability to train and collaborate effectively across multidisciplinary teams. Additional Information
Location: Schwartz Building, 1250 First Avenue, New York, NY Schedule: Monday – Friday, 9 am – 5 pm Reports to: Pathology and Laboratory Medicine Supervisor, Molecular Diagnostic Lab Helpful Links
Compensation Philosophy Benefits Pay Range: $83,800.00 – $134,000.00 FSLA Status: Exempt Closing: At MSK, we believe in fair, competitive pay that reflects your job, experience, and skills. MSK is an equal opportunity and affirmative action employer committed to diversity and inclusion in all aspects of recruiting and employment. All qualified individuals are encouraged to apply and will receive consideration without regard to race, color, gender, gender identity or expression, sexual orientation, national origin, age, religion, creed, disability, veteran status or any other factor which cannot lawfully be used as a basis for an employment decision. Federal law requires employers to provide reasonable accommodation to qualified individuals with disabilities. Please tell us if you require a reasonable accommodation to apply for a job or to perform your job. Examples of reasonable accommodation include making a change to the application process or work procedures, providing documents in an alternate format, using a sign language interpreter, or using specialized equipment.
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