Drug discovery / Synthetic chemistry role
ClinLab Solutions Group, Cambridge, MA, United States
We are seeking a skilled and highly motivated chemist to join our dynamic, interdisciplinary drug discovery team. In this lab-based role, you will contribute to the development of our discovery engine and support medicinal chemistry efforts across multiple programs. This position offers the opportunity to work flexibly across solution-phase small molecule synthesis and automated peptide synthesis, depending on project needs.
Ideal candidates will be passionate and energetic, with strong hands-on synthetic organic chemistry experience and a desire to contribute in a fast-paced discovery environment.
Specific responsibilities include:
Contributes to peptide library synthesis to optimize binding affinity, permeability, and other drug-like properties. Operate automated peptide synthesizers and conduct solid-supported and solution-phase reactions as required by project demands. Troubleshoot synthetic challenges and propose practical solutions to advance programs efficiently. Maintain accurate experimental records and communicate results clearly to project teams. Work collaboratively within project teams to address evolving chemistry needs across programs. What you’ll need to be successful:
BS or MS in Chemistry or a related field with 1-3+ years of industry or academic research experience in synthetic organic chemistry. Strong foundation in organic chemistry, reaction mechanisms, and modern synthetic methods. Hands-on laboratory experience, including reaction setup, purification, and characterization. Experience with LC-MS and standard analytical techniques is required. Experience with peptide synthesis (SPPS or automated platforms) is preferred but not required. Flexibility and willingness to transition between small molecule and peptide synthesis as project priorities evolve. Strong problem-solving skills, attention to detail, and ability to meet deadlines. Excellent written and oral communication skills and the ability to work effectively in a collaborative team environment. Ability to work on-site and attend in-person meetings.
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Contributes to peptide library synthesis to optimize binding affinity, permeability, and other drug-like properties. Operate automated peptide synthesizers and conduct solid-supported and solution-phase reactions as required by project demands. Troubleshoot synthetic challenges and propose practical solutions to advance programs efficiently. Maintain accurate experimental records and communicate results clearly to project teams. Work collaboratively within project teams to address evolving chemistry needs across programs. What you’ll need to be successful:
BS or MS in Chemistry or a related field with 1-3+ years of industry or academic research experience in synthetic organic chemistry. Strong foundation in organic chemistry, reaction mechanisms, and modern synthetic methods. Hands-on laboratory experience, including reaction setup, purification, and characterization. Experience with LC-MS and standard analytical techniques is required. Experience with peptide synthesis (SPPS or automated platforms) is preferred but not required. Flexibility and willingness to transition between small molecule and peptide synthesis as project priorities evolve. Strong problem-solving skills, attention to detail, and ability to meet deadlines. Excellent written and oral communication skills and the ability to work effectively in a collaborative team environment. Ability to work on-site and attend in-person meetings.
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