Downstream Associate
Sino Biological, Inc., Houston, TX, United States
Sino Biological is a world-renowned reagent supplier and contract research organization, listed on ChiNext of the Shenzhen Stock Exchange (301047 Sino Biological Inc.). Our core technology platform is an in-house-developed mammalian cell-based recombinant expression system that leverages proprietary reagents and processes for high-efficiency production of antigens and antibodies. We are headquartered in Beijing, China, with a U.S. base in the Greater Philadelphia area, an office and bioprocessing center in Houston, Texas, and subsidiaries in Frankfurt, Germany, and Kawasaki, Japan. Sino Biological is committed to providing high-quality recombinant protein and antibody reagents and to being a one-stop technical services shop for life science researchers worldwide. All of our products are independently developed and produced. In addition, we offer pharmaceutical companies and biotechnology firms pre-clinical production technology services for hundreds of monoclonal antibody drug candidates.
Job Description This entry-level, hands‑on role offers experience in both downstream bioprocessing and protein quality control (QC) for individuals looking to launch their industrial biotechnology career. As an Associate, Downstream, you’ll assist in recombinant protein and antibody expression using mammalian cell cultures, while also supporting QC testing to evaluate product quality. You’ll work closely with project scientists, contributing to aseptic cell culture, transfection, harvest, and analytical testing, all with an emphasis on accuracy, documentation, and collaboration across teams. Flexibility is key, including potential weekend work, early/late weekday shifts, and participation in essential lab maintenance or cross‑functional support tasks as needed.
Responsibilities
Maintaining HPLC and other quality control instruments to ensure ongoing operational
Training assigned associates and supporting quality systems as needed and
ensuring their readiness to work independently.
Analytical Testing & Characterization:
Perform in-depth analysis of purified proteins, including purity (SDS-PAGE, HPLC/SEC), structural integrity (CE-SDS, iCIEF), and functionality (BLI, ELISA, enzyme activity assays).
Method Development & Validation:
Develop, optimize, and validate new analytical methods to support the characterization of complex proteins, including developing stability‑indicating assays.
Documentation & Reporting:
Maintain detailed laboratory records in compliance with Good Laboratory Practices (GLP). Prepare certificates of analysis and technical reports.
Quality Control & Compliance:
Review QC documentation, investigate out-of-specification (OOS) or out-of-trend (OOT) results, and ensure adherence to standard operating procedures (SOPs).
Instrument Maintenance:
Maintain, calibrate, and troubleshoot high‑end analytical equipment (HPLC, Plate readers, Octet, etc.).
Collaboration & Support:
Work with protein purification teams to identify and resolve process-related issues, providing analytical feedback to optimize production workflows.
Requirements
Bachelor’s degree (BA or BS) in Biology, Cell Biology, Biochemistry, Biotechnology, or a related field.
0–3 years of lab experience with mammalian cell culture; HEK293 and CHO preferred.
Familiarity with suspension culture and aseptic techniques.
Basic experience with analytical assays such as SDS-PAGE, HPLC-SEC, UV-Vis, or endotoxin testing is a plus.
Strong attention to detail, documentation, and troubleshooting skills.
Flexible and adaptable to varying schedules or project demands.
Effective communication skills and the ability to work collaboratively in a team‑oriented environment.
Must be able to lift and move 25–50 lbs as needed.
Why Join Us at C4B? Working at Sino Biological’s C4B facility isn’t just another lab job, it’s a chance to be part of something bigger. Here are just a few of the unique benefits of our Houston site:
World‑class location: Be part of the Texas Medical Center, the largest medical complex in the world, where biotech innovation thrives.
Beautiful work environment: Enjoy a brand‑new, state‑of‑the‑art facility designed for collaboration and scientific excellence.
Free onsite parking: Skip the hassle and expense of parking in the Medical Center, we’ve got you covered.
Free onsite gym: Stay active and energized with convenient access to fitness facilities right at work.
Career growth opportunities: Learn directly from industry professionals while growing your career at a global biotech company.
Supportive team culture: A welcoming, team‑first workplace that values diversity, collaboration, and professional development.
Join Us in Advancing Scientific Innovation! Be a part of Sino Biological and contribute to groundbreaking scientific advancements worldwide. Apply today to join our dynamic team!
Sino Biological is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.
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Job Description This entry-level, hands‑on role offers experience in both downstream bioprocessing and protein quality control (QC) for individuals looking to launch their industrial biotechnology career. As an Associate, Downstream, you’ll assist in recombinant protein and antibody expression using mammalian cell cultures, while also supporting QC testing to evaluate product quality. You’ll work closely with project scientists, contributing to aseptic cell culture, transfection, harvest, and analytical testing, all with an emphasis on accuracy, documentation, and collaboration across teams. Flexibility is key, including potential weekend work, early/late weekday shifts, and participation in essential lab maintenance or cross‑functional support tasks as needed.
Responsibilities
Maintaining HPLC and other quality control instruments to ensure ongoing operational
Training assigned associates and supporting quality systems as needed and
ensuring their readiness to work independently.
Analytical Testing & Characterization:
Perform in-depth analysis of purified proteins, including purity (SDS-PAGE, HPLC/SEC), structural integrity (CE-SDS, iCIEF), and functionality (BLI, ELISA, enzyme activity assays).
Method Development & Validation:
Develop, optimize, and validate new analytical methods to support the characterization of complex proteins, including developing stability‑indicating assays.
Documentation & Reporting:
Maintain detailed laboratory records in compliance with Good Laboratory Practices (GLP). Prepare certificates of analysis and technical reports.
Quality Control & Compliance:
Review QC documentation, investigate out-of-specification (OOS) or out-of-trend (OOT) results, and ensure adherence to standard operating procedures (SOPs).
Instrument Maintenance:
Maintain, calibrate, and troubleshoot high‑end analytical equipment (HPLC, Plate readers, Octet, etc.).
Collaboration & Support:
Work with protein purification teams to identify and resolve process-related issues, providing analytical feedback to optimize production workflows.
Requirements
Bachelor’s degree (BA or BS) in Biology, Cell Biology, Biochemistry, Biotechnology, or a related field.
0–3 years of lab experience with mammalian cell culture; HEK293 and CHO preferred.
Familiarity with suspension culture and aseptic techniques.
Basic experience with analytical assays such as SDS-PAGE, HPLC-SEC, UV-Vis, or endotoxin testing is a plus.
Strong attention to detail, documentation, and troubleshooting skills.
Flexible and adaptable to varying schedules or project demands.
Effective communication skills and the ability to work collaboratively in a team‑oriented environment.
Must be able to lift and move 25–50 lbs as needed.
Why Join Us at C4B? Working at Sino Biological’s C4B facility isn’t just another lab job, it’s a chance to be part of something bigger. Here are just a few of the unique benefits of our Houston site:
World‑class location: Be part of the Texas Medical Center, the largest medical complex in the world, where biotech innovation thrives.
Beautiful work environment: Enjoy a brand‑new, state‑of‑the‑art facility designed for collaboration and scientific excellence.
Free onsite parking: Skip the hassle and expense of parking in the Medical Center, we’ve got you covered.
Free onsite gym: Stay active and energized with convenient access to fitness facilities right at work.
Career growth opportunities: Learn directly from industry professionals while growing your career at a global biotech company.
Supportive team culture: A welcoming, team‑first workplace that values diversity, collaboration, and professional development.
Join Us in Advancing Scientific Innovation! Be a part of Sino Biological and contribute to groundbreaking scientific advancements worldwide. Apply today to join our dynamic team!
Sino Biological is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.
#J-18808-Ljbffr