Senior Director, Oncology Therapeutic Area Lead (TAL), Drug Metabolism, Pharmaco
Takeda, Boston, MA, United States
Job Description
This position is required for the Oncology (ONC) Therapeutic Area Lead in DMPK&M at Takeda. The role oversees the DMPK&M strategy for the ONC portfolio, leading a team and ensuring execution of project plans, regulatory submissions, and strategic alignment with cross‑functional stakeholders.
Objectives / Purpose
Supervise and lead a team of DMPK&M project representatives and Modeling & Simulation (M&S) scientists to deliver on Takeda’s research pipeline in the ONC therapeutic area.
Oversee the DMPK&M strategy of the ONC portfolio, ensuring execution of project plans, translation, dose‑optimization strategies and review of regulatory filings.
Participate in therapeutic‑area driven discussions and partner with cross‑functional stakeholders to align on Takeda’s strategic framework; contribute to portfolio strategy and global business operations within DMPK&M.
Demonstrate leadership experience in guiding talented teams; key member of the Global DMPK&M leadership team that drives department strategy and strengthens partnerships across R&D.
Lead a team of DMPK project representatives and modeling scientists providing key scientific and strategic input to research projects.
Accountable for strategic planning and scientific oversight of the discovery and development portfolio for the ONC therapeutic area.
Support DMPK&M Head in strategic execution of the DMPK&M Vision and Mission.
Drive the development of organizational culture and capabilities by building alliances across R&D.
Scientific Responsibilities
Provide scientific leadership and strategic guidance on stage‑appropriate questions related to DMPK&M to ensure the selection and development of clinical candidates with optimal drug development characteristics.
Build and enhance an external network to monitor scientific developments, novel strategies, partnership opportunities, and the competitive & regulatory landscape in ONC therapeutic areas.
Advise, review, and approve milestone presentations and PRC narratives; oversee and participate in regulatory activities, including review and approval of submission packages in the ONC therapeutic area.
Strategic Responsibilities
Act as the DMPK&M functional representative in governance committees and discussions on prioritization, strategy, resources, timelines, and decision‑making criteria.
Facilitate alignment of DMPK&M strategy with DDU and TAU portfolio goals as the ONC Therapeutic Area Lead.
Collaborate with DDU and TAU senior leaders, communicating needs, strategy and execution plans, and consult with DMPK leadership to ensure alignment of resources and goals.
Accountable for appropriate resourcing of project support by collaborating with the Global DMPK&M leadership team.
Resources and review in‑licensing evaluations for the therapeutic area.
Management Responsibilities
Actively attract, develop and retain talent.
Dimensions and Aspects Technical / Functional (Line) Expertise
Comprehensive understanding of drug discovery and development, the pharmaceutical industry, and DMPK&M science.
Leadership
Collaboratively work with partners across the organization.
Work across functions, regions, and cultures.
Inspire, motivate and drive results; excellent communicator.
Team player engendering credibility and confidence.
Distill complex issues to simple terms.
Demonstrate leadership presence and confidence; embrace diversity and inclusion.
Build cross‑functional and geographic teams with the right skills.
Invest time in enhancing others’ skills.
Decision‑Making & Autonomy
Provide input on highly complex decisions impacting the functional area.
Accountable for decision‑making for the designated function.
Seek diverse input from stakeholders to drive innovative solutions.
Incorporate feedback and implement vision and strategy swiftly.
Interaction
Navigate external and internal changes, leading others through change.
Build a broad network of relationships within Takeda and external partners.
Represent the function in negotiations and resolve conflict constructively.
Collaborate effectively with interfacing Takeda functions.
Innovation
Forward‑thinking, recommending and implementing continuous innovation.
Challenge the status‑quo and propose innovative solutions.
Take risks to accelerate time to market.
Complexity
Work in a global ecosystem with high complexity.
Understand and see the enterprise‑level perspective.
Education, Behavioural Competencies and Skills
PhD (15+ yrs), MS (21+ yrs), or BS (23+ yrs) with at least 9 yrs of industry experience in pharmaceutical DMPK and modelling.
Good understanding of the (NS, ONC or ONC) DDU/TAU portfolio, disease indications, and typical DMPK&M considerations.
Deep drug discovery and development experience and profound DMPK&M expertise.
Experience managing pre‑clinical scientists and preparing INDs, CTDs, NDAs and MAAs.
Proactive, innovative, strong problem‑solving.
Exceptional leadership, coaching, and employee‑development skills.
Strategically work in cross‑functional and matrix environments.
In‑depth knowledge of the functional area, business strategies and company goals.
Excellent written, presentation and verbal communication skills.
Track record of sustained scientific contributions in DMPK and modelling, demonstrated by publications and presentations.
Position Classification Hybrid – in accordance with Takeda’s Hybrid and Remote Work policy.
Location Boston, MA
Salary and Benefits U.S. Base Salary Range:
$212,000.00 – $333,190.00
Eligibility for short‑term and/or long‑term incentives, medical, dental, vision insurance, 401(k) plan with company match, disability coverage, life insurance, tuition reimbursement, paid volunteer time off, company holidays, well‑being benefits, sick time, and paid vacation as applicable.
EEO Statement Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran or any other protected veteran in accordance with applicable federal, state and local laws and any other characteristic protected by law.
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Objectives / Purpose
Supervise and lead a team of DMPK&M project representatives and Modeling & Simulation (M&S) scientists to deliver on Takeda’s research pipeline in the ONC therapeutic area.
Oversee the DMPK&M strategy of the ONC portfolio, ensuring execution of project plans, translation, dose‑optimization strategies and review of regulatory filings.
Participate in therapeutic‑area driven discussions and partner with cross‑functional stakeholders to align on Takeda’s strategic framework; contribute to portfolio strategy and global business operations within DMPK&M.
Demonstrate leadership experience in guiding talented teams; key member of the Global DMPK&M leadership team that drives department strategy and strengthens partnerships across R&D.
Lead a team of DMPK project representatives and modeling scientists providing key scientific and strategic input to research projects.
Accountable for strategic planning and scientific oversight of the discovery and development portfolio for the ONC therapeutic area.
Support DMPK&M Head in strategic execution of the DMPK&M Vision and Mission.
Drive the development of organizational culture and capabilities by building alliances across R&D.
Scientific Responsibilities
Provide scientific leadership and strategic guidance on stage‑appropriate questions related to DMPK&M to ensure the selection and development of clinical candidates with optimal drug development characteristics.
Build and enhance an external network to monitor scientific developments, novel strategies, partnership opportunities, and the competitive & regulatory landscape in ONC therapeutic areas.
Advise, review, and approve milestone presentations and PRC narratives; oversee and participate in regulatory activities, including review and approval of submission packages in the ONC therapeutic area.
Strategic Responsibilities
Act as the DMPK&M functional representative in governance committees and discussions on prioritization, strategy, resources, timelines, and decision‑making criteria.
Facilitate alignment of DMPK&M strategy with DDU and TAU portfolio goals as the ONC Therapeutic Area Lead.
Collaborate with DDU and TAU senior leaders, communicating needs, strategy and execution plans, and consult with DMPK leadership to ensure alignment of resources and goals.
Accountable for appropriate resourcing of project support by collaborating with the Global DMPK&M leadership team.
Resources and review in‑licensing evaluations for the therapeutic area.
Management Responsibilities
Actively attract, develop and retain talent.
Dimensions and Aspects Technical / Functional (Line) Expertise
Comprehensive understanding of drug discovery and development, the pharmaceutical industry, and DMPK&M science.
Leadership
Collaboratively work with partners across the organization.
Work across functions, regions, and cultures.
Inspire, motivate and drive results; excellent communicator.
Team player engendering credibility and confidence.
Distill complex issues to simple terms.
Demonstrate leadership presence and confidence; embrace diversity and inclusion.
Build cross‑functional and geographic teams with the right skills.
Invest time in enhancing others’ skills.
Decision‑Making & Autonomy
Provide input on highly complex decisions impacting the functional area.
Accountable for decision‑making for the designated function.
Seek diverse input from stakeholders to drive innovative solutions.
Incorporate feedback and implement vision and strategy swiftly.
Interaction
Navigate external and internal changes, leading others through change.
Build a broad network of relationships within Takeda and external partners.
Represent the function in negotiations and resolve conflict constructively.
Collaborate effectively with interfacing Takeda functions.
Innovation
Forward‑thinking, recommending and implementing continuous innovation.
Challenge the status‑quo and propose innovative solutions.
Take risks to accelerate time to market.
Complexity
Work in a global ecosystem with high complexity.
Understand and see the enterprise‑level perspective.
Education, Behavioural Competencies and Skills
PhD (15+ yrs), MS (21+ yrs), or BS (23+ yrs) with at least 9 yrs of industry experience in pharmaceutical DMPK and modelling.
Good understanding of the (NS, ONC or ONC) DDU/TAU portfolio, disease indications, and typical DMPK&M considerations.
Deep drug discovery and development experience and profound DMPK&M expertise.
Experience managing pre‑clinical scientists and preparing INDs, CTDs, NDAs and MAAs.
Proactive, innovative, strong problem‑solving.
Exceptional leadership, coaching, and employee‑development skills.
Strategically work in cross‑functional and matrix environments.
In‑depth knowledge of the functional area, business strategies and company goals.
Excellent written, presentation and verbal communication skills.
Track record of sustained scientific contributions in DMPK and modelling, demonstrated by publications and presentations.
Position Classification Hybrid – in accordance with Takeda’s Hybrid and Remote Work policy.
Location Boston, MA
Salary and Benefits U.S. Base Salary Range:
$212,000.00 – $333,190.00
Eligibility for short‑term and/or long‑term incentives, medical, dental, vision insurance, 401(k) plan with company match, disability coverage, life insurance, tuition reimbursement, paid volunteer time off, company holidays, well‑being benefits, sick time, and paid vacation as applicable.
EEO Statement Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran or any other protected veteran in accordance with applicable federal, state and local laws and any other characteristic protected by law.
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