Chemist - Process Translation and Execution Lilly Medicine Foundry
BioSpace, Lebanon, IN, United States
We are seeking passionate and agile chemists to join the Process Translation and Execution (PTE) team and help bring the Lilly Medicine Foundry’s vision to life.
Responsibilities
Actively involved in receiving chemistry from early phase process research and development labs and evaluating the safety of the incoming procedures in collaboration with the safety group and process engineering.
Ordering and staging chemicals.
Obtain reference materials and participate in setting up analytical methods.
Reprocess and analyze analytical data to make fact‑based decisions.
Efficiently summarize and present chemistry results and challenges.
Perform familiarization reactions to ensure plant readiness of process steps including chemical reactions, distillations, extractions, and crystallization/isolations at the Lilly Medicine Foundry.
Perform use‑tests of key raw materials and document Definitive Lab Trials of processes to confirm plant readiness.
Maintain a well‑organized and detailed lab notebook with accurate descriptions of the chemistry, observations, and organized analytical data to enable the preparation of technical packages/technical transfers and accurate replication in receiving labs.
Documentation: author, review technical documents, including tech transfer plan, standard operating procedures (SOPs), batch records, campaign summary reports, and deviation reports.
Process improvement: apply scientific knowledge to identify areas for improvement and implement new technologies or procedures.
Contribute to process troubleshooting and investigations by supporting process deviations, quality events, and non‑conformances. Collaborate with teams to perform root cause analysis (RCA) and develop effective corrective and preventive actions (CAPAs).
Basic Requirements
B.S. or M.S. in chemistry, chemical engineering, or related field.
2+ years of experience in manufacturing environments involving synthetic small molecule API or drug substance, or fine chemical synthesis is preferred.
Qualified applicants must be authorized to work in the United States on a full‑time basis. This role does not sponsor visas or work authorization (including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1).
Additional Skills and Preferences
Working knowledge of organic chemistry and mechanisms and application to reaction improvement and optimization.
Experience with synthetic chemistry techniques used for developing and scaling‑up chemical reactions. Experience using process chemistry concepts is a plus.
Proficiency with the purification of chemicals via extraction, crystallization, chromatography, and distillation.
Comfortable working with larger sized glass equipment.
Highly motivated, able to learn rapidly, and demonstrates strong attention to detail.
Has experience creating batch records and conducting scale‑up experiments according to those records.
Ability to prioritize multiple activities and manage ambiguity.
Experience with a variety of analytical techniques: HPLC/UPLC, LC-MS, GC, NMR, IR, KF, XRPD, etc.
Process quantification and acquiring mass balance for products and by‑products.
Demonstrated ability to drive projects and accept change.
Communication skills: Excellent written and verbal communication skills for technical report writing, presentations, and effective collaboration across teams.
Familiarity with crystallization and understanding of polymorphism and particle size control, and safe handling of solids/dry end processing.
Problem‑solving skills: Proven ability to analyze data, perform root cause analysis, and resolve complex technical challenges.
Ability to work cross‑functionally across disciplines and levels with engineers, analytical chemists, chemical technicians, safety and quality representatives.
Other Information
Initial location: Lilly Technology Center, Indianapolis.
Permanent location: New Lilly Medicines Foundry, Lebanon, Indiana.
Limited domestic and international travel ( Role requires ability to work in manufacturing and laboratory environments.
Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $66,000 - $171,600. Full‑time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance).
Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company‑sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day‑care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well‑being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities). Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs at its sole discretion.
We are dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form for further assistance.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
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Responsibilities
Actively involved in receiving chemistry from early phase process research and development labs and evaluating the safety of the incoming procedures in collaboration with the safety group and process engineering.
Ordering and staging chemicals.
Obtain reference materials and participate in setting up analytical methods.
Reprocess and analyze analytical data to make fact‑based decisions.
Efficiently summarize and present chemistry results and challenges.
Perform familiarization reactions to ensure plant readiness of process steps including chemical reactions, distillations, extractions, and crystallization/isolations at the Lilly Medicine Foundry.
Perform use‑tests of key raw materials and document Definitive Lab Trials of processes to confirm plant readiness.
Maintain a well‑organized and detailed lab notebook with accurate descriptions of the chemistry, observations, and organized analytical data to enable the preparation of technical packages/technical transfers and accurate replication in receiving labs.
Documentation: author, review technical documents, including tech transfer plan, standard operating procedures (SOPs), batch records, campaign summary reports, and deviation reports.
Process improvement: apply scientific knowledge to identify areas for improvement and implement new technologies or procedures.
Contribute to process troubleshooting and investigations by supporting process deviations, quality events, and non‑conformances. Collaborate with teams to perform root cause analysis (RCA) and develop effective corrective and preventive actions (CAPAs).
Basic Requirements
B.S. or M.S. in chemistry, chemical engineering, or related field.
2+ years of experience in manufacturing environments involving synthetic small molecule API or drug substance, or fine chemical synthesis is preferred.
Qualified applicants must be authorized to work in the United States on a full‑time basis. This role does not sponsor visas or work authorization (including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1).
Additional Skills and Preferences
Working knowledge of organic chemistry and mechanisms and application to reaction improvement and optimization.
Experience with synthetic chemistry techniques used for developing and scaling‑up chemical reactions. Experience using process chemistry concepts is a plus.
Proficiency with the purification of chemicals via extraction, crystallization, chromatography, and distillation.
Comfortable working with larger sized glass equipment.
Highly motivated, able to learn rapidly, and demonstrates strong attention to detail.
Has experience creating batch records and conducting scale‑up experiments according to those records.
Ability to prioritize multiple activities and manage ambiguity.
Experience with a variety of analytical techniques: HPLC/UPLC, LC-MS, GC, NMR, IR, KF, XRPD, etc.
Process quantification and acquiring mass balance for products and by‑products.
Demonstrated ability to drive projects and accept change.
Communication skills: Excellent written and verbal communication skills for technical report writing, presentations, and effective collaboration across teams.
Familiarity with crystallization and understanding of polymorphism and particle size control, and safe handling of solids/dry end processing.
Problem‑solving skills: Proven ability to analyze data, perform root cause analysis, and resolve complex technical challenges.
Ability to work cross‑functionally across disciplines and levels with engineers, analytical chemists, chemical technicians, safety and quality representatives.
Other Information
Initial location: Lilly Technology Center, Indianapolis.
Permanent location: New Lilly Medicines Foundry, Lebanon, Indiana.
Limited domestic and international travel ( Role requires ability to work in manufacturing and laboratory environments.
Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $66,000 - $171,600. Full‑time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance).
Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company‑sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day‑care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well‑being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities). Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs at its sole discretion.
We are dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form for further assistance.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
#J-18808-Ljbffr