Mount Sinai Medical Center
Description
Title:
Postdoctoral Fellow TR05 (partially ISMMS funded)
Salary:
$74,692 total ($36,000 external funding)
Department:
Medicine/Nephrology
Physical work location:
1468 Madison Avenue, Annenberg 23-16, New York, NY 10029
Name PI or Supervisor:
John Cijiang He
Web link to Lab:
https://labs.icahn.mssm.edu/helab/meet-the-team/
Web link to Department:
https://icahn.mssm.edu/about/departments/medicine/nephrology
Administrative Contact:
Irene Beaulieu, email: Irene.Beaulieu@mssm.edu
Responsibilities Background and Description of Research Project:
Diabetic kidney disease is the number one cause of kidney failure in the USA as well as in the world.
Its underlined pathogenesis remains unclear and the treatment is limited.
We have been using systems biology approach to study its pathogenesis in order to identify potential new drug targets to treat this disease.
Recently, we identified LRG1 as a key molecule involving in renal endothelial cell and tubular cell injury in diabetic kidney disease.
The current project will focus on the role of LRG1 in the pathogenesis of diabetic kidney disease.
We will use in vitro assays and in vivo animal models to confirm the critical role of LRG1 in kidney cell injury in diabetic kidney disease.
Technical Duties (include any protocols):
Perform in vitro cell cultures of glomerular endothelial cells, tubular endothelial cells, and tubular epithelial cells and test whether overexpression or knockdown of LRG1 affects cell function and downstream signaling pathways.
We have generated transgenic mouse models with overexpression or knockdown of LRG1 in endothelial cells and tubular cells.
We will test whether these mice develop more or less kidney injury.
Techniques include cell culture, western blot, qPCR, genotyping of mice, mouse breeding, kidney histology analysis, immunostaining, determination of urine albumin and renal function.
Qualifications Educational and other Requirements for the position:
Postdoc should have medical training (MD equivalent) or basic science training and is familiar with kidney disease pathogenesis (Nephrology training).
Experience Required:
Candidate should have basic training in medical research and know how to perform basic benchwork and animal studies.
Equal Opportunity Employer The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws.
We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law.
We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported.
Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization.
Compensation The Mount Sinai Health System (MSHS) provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements.
The salary range for the role is $72,500 - $80,000 Annually.
Actual salaries depend on a variety of factors, including experience, education, and operational need.
The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.
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Postdoctoral Fellow TR05 (partially ISMMS funded)
Salary:
$74,692 total ($36,000 external funding)
Department:
Medicine/Nephrology
Physical work location:
1468 Madison Avenue, Annenberg 23-16, New York, NY 10029
Name PI or Supervisor:
John Cijiang He
Web link to Lab:
https://labs.icahn.mssm.edu/helab/meet-the-team/
Web link to Department:
https://icahn.mssm.edu/about/departments/medicine/nephrology
Administrative Contact:
Irene Beaulieu, email: Irene.Beaulieu@mssm.edu
Responsibilities Background and Description of Research Project:
Diabetic kidney disease is the number one cause of kidney failure in the USA as well as in the world.
Its underlined pathogenesis remains unclear and the treatment is limited.
We have been using systems biology approach to study its pathogenesis in order to identify potential new drug targets to treat this disease.
Recently, we identified LRG1 as a key molecule involving in renal endothelial cell and tubular cell injury in diabetic kidney disease.
The current project will focus on the role of LRG1 in the pathogenesis of diabetic kidney disease.
We will use in vitro assays and in vivo animal models to confirm the critical role of LRG1 in kidney cell injury in diabetic kidney disease.
Technical Duties (include any protocols):
Perform in vitro cell cultures of glomerular endothelial cells, tubular endothelial cells, and tubular epithelial cells and test whether overexpression or knockdown of LRG1 affects cell function and downstream signaling pathways.
We have generated transgenic mouse models with overexpression or knockdown of LRG1 in endothelial cells and tubular cells.
We will test whether these mice develop more or less kidney injury.
Techniques include cell culture, western blot, qPCR, genotyping of mice, mouse breeding, kidney histology analysis, immunostaining, determination of urine albumin and renal function.
Qualifications Educational and other Requirements for the position:
Postdoc should have medical training (MD equivalent) or basic science training and is familiar with kidney disease pathogenesis (Nephrology training).
Experience Required:
Candidate should have basic training in medical research and know how to perform basic benchwork and animal studies.
Equal Opportunity Employer The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws.
We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law.
We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported.
Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization.
Compensation The Mount Sinai Health System (MSHS) provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements.
The salary range for the role is $72,500 - $80,000 Annually.
Actual salaries depend on a variety of factors, including experience, education, and operational need.
The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.
#J-18808-Ljbffr