Director, ADC Chemistry

Our client is a publicly traded oncology biotech with multiple approved products and a growing pipeline.

The Director, ADC Chemistry will play a key role in leading the efforts for advancing the discovery and development of antibody drug conjugates (ADCs) for our client by leveraging his/her knowledge of medicinal chemistry. They will support efforts in discovery research and early process development activities of ongoing and new ADC projects.

Key Responsibilities:

• Lead, build and execute antibody on ADC pipeline programs.
• Provides ADC chemistry expertise in state-of-the-art ADC technologies including linkers, payloads, novel conjugation methods, analytical assessments and testing and bring novel ideas to POC.
• Technical expert from Biotherapeutics group on ADC-related internal projects.
• Interacts and collaborates with internal departments and external colleagues to discuss and resolve project needs and issues in research and early development of ADCs.
• Provides support in evaluation of ADC research platforms and preclinical licensing candidates as needed.
• Provides critical scientific/technical data analysis, interpretation of experiments and report writing.
• Design, implement and oversee the execution of in vitro bio-functional assays such as efficacy/bystander/metabolite assessments/bioanalysis/mechanism of action studies/etc. for bioconjugate candidate screening and selection as needed from discovery to lead selection.
• Effectively communicates scientific concepts, study findings and interpretations to multi-disciplinary teams.
• Interacts and collaborates with internal departments to deliver quality and timely findings in support of drug candidate advancement.
• Lead scientific efforts in cancer target identification/validation.
• Manage, supervise, plan and prioritize workflow for laboratory-based scientific staff.
• Follows company intellectual property and compliance policies and practices.
• Complies with company health and safety policies and general laboratory practices.

Key Requirements:

• Bachelor’s degree in chemistry, biochemistry, biology or a related discipline and a minimum of thirteen years of related experience; or,
• Master’s degree in chemistry, biochemistry, biology or a related discipline and a minimum of eleven years of related experience; or,
• PhD degree in chemistry, biochemistry, biology or a related discipline and a minimum of eight years of related experience; or,
• Equivalent combination of education and experience.
• Knowledge of state-of-the-art in different aspects of ADC research including conjugation technologies, linkers and payloads.
• Extensive knowledge of ADC platforms, applications and development. Comprehensive understanding of current approaches and emerging technologies in ADCs.
• Strong background in chemistry and/or biochemistry.
• Knowledge of intellectual property matters, and issues related to ADCs.
• The knowledge to apply advanced scientific and technical principles, theories and concepts, and contribute to the development of new principles and concepts.
• Ability to work independently, excellent time management and organization skills to manage multiple projects simultaneously.
• Excellent written, oral and interpersonal communication skills.

Location: Bay Area (onsite)

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