Post doc in Structural Biology
Aretè & Cocchi Technology, Italy, NY, United States
Project: Development of novel small molecules that inhibit the growth of early stage melanoma tumors
Commitment & contract: co.co.co 12 months
At IIT, we are committed to advancing human-centered Science and Technology to address the most urgent societal challenges of our era. We foster excellence in both fundamental and applied research, spanning fields such as neuroscience and cognition, humanoid technologies and robotics, artificial intelligence, nanotechnology, and material sciences, offering a truly interdisciplinary scientific experience. Our approach integrates cutting‑edge tools and technology, empowering researchers to push the limits of knowledge and innovation.
We are dedicated to providing equal employment opportunities and fostering diversity in all its forms, creating an inclusive environment. We value the unique experiences, knowledge, backgrounds, cultures, and perspectives of our people. By embracing diversity, we believe science can achieve its fullest potential.
THE ROLE The Molecular Modeling and Drug Discovery research unit is coordinated by Dr. Marco De Vivo, who has extensive experience in small‑molecule drug discovery. The lab is a multicultural, multidisciplinary group where you will work closely with both computational and experimental researchers in medicinal chemistry and biochemistry for drug discovery. The research focuses on applying computational methods (primarily molecular dynamics simulations, docking, and binding free energy calculations) to dissect the mechanisms of molecular targets and design potent inhibitors and drug‑like molecules.
Within the team, your main responsibilities will include:
Enzyme‑based in vitro assay setup and characterization of the activity and mechanism of action of small molecules in vitro.
Protein crystallization and structure determination.
Mammalian cell culture techniques and characterization of the mechanism of action of small molecules in cell‑based assays using human cancer cell lines.
Characterization of protein‑protein and/or protein‑ligand interaction using biophysical methods such as ITC, MST or SPR.
Knowledge and hands‑on experience in molecular biology techniques, such as cloning, site‑directed mutagenesis, PCR, western blotting, etc.
Familiarity with imaging techniques and quantitative image analysis.
This open position/research is financed by AIRC – Foundation for Cancer Research in Italy within the AIRC IG 2024 – De Vivo – Rif. 30631: Design and characterization of RHOA interaction inhibitors to treat early‑stage melanoma tumors.
ESSENTIAL REQUIREMENTS
PhD degree in Biology, Biochemistry, Biophysics, Biotechnology or closely related fields, with a strong record of research productivity.
Strong publication record.
The ability to properly report, organize and publish research data.
Documented experience in coaching junior scientists.
Good command in spoken and written English.
ADDITIONAL SKILLS
Strong problem‑solving attitude.
High motivation to learn.
Spirit of innovation and creativity.
Good in time and priority management.
Ability to work in a challenging and international environment.
Ability to work independently and collaboratively in a highly interdisciplinary environment.
COMPENSATION & BENEFITS
Competitive salary package for international standards. It will reflect experience and expertise and will be determined after the interview.
Wide range of staff discounts.
Flexible working time.
Possibility to have fiscal benefits: two tax reliefs currently available – the fiscal benefit for Researchers and Teachers from abroad (Tremonti) and the one for Impatriate workers (Internationalization Decree).
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Commitment & contract: co.co.co 12 months
At IIT, we are committed to advancing human-centered Science and Technology to address the most urgent societal challenges of our era. We foster excellence in both fundamental and applied research, spanning fields such as neuroscience and cognition, humanoid technologies and robotics, artificial intelligence, nanotechnology, and material sciences, offering a truly interdisciplinary scientific experience. Our approach integrates cutting‑edge tools and technology, empowering researchers to push the limits of knowledge and innovation.
We are dedicated to providing equal employment opportunities and fostering diversity in all its forms, creating an inclusive environment. We value the unique experiences, knowledge, backgrounds, cultures, and perspectives of our people. By embracing diversity, we believe science can achieve its fullest potential.
THE ROLE The Molecular Modeling and Drug Discovery research unit is coordinated by Dr. Marco De Vivo, who has extensive experience in small‑molecule drug discovery. The lab is a multicultural, multidisciplinary group where you will work closely with both computational and experimental researchers in medicinal chemistry and biochemistry for drug discovery. The research focuses on applying computational methods (primarily molecular dynamics simulations, docking, and binding free energy calculations) to dissect the mechanisms of molecular targets and design potent inhibitors and drug‑like molecules.
Within the team, your main responsibilities will include:
Enzyme‑based in vitro assay setup and characterization of the activity and mechanism of action of small molecules in vitro.
Protein crystallization and structure determination.
Mammalian cell culture techniques and characterization of the mechanism of action of small molecules in cell‑based assays using human cancer cell lines.
Characterization of protein‑protein and/or protein‑ligand interaction using biophysical methods such as ITC, MST or SPR.
Knowledge and hands‑on experience in molecular biology techniques, such as cloning, site‑directed mutagenesis, PCR, western blotting, etc.
Familiarity with imaging techniques and quantitative image analysis.
This open position/research is financed by AIRC – Foundation for Cancer Research in Italy within the AIRC IG 2024 – De Vivo – Rif. 30631: Design and characterization of RHOA interaction inhibitors to treat early‑stage melanoma tumors.
ESSENTIAL REQUIREMENTS
PhD degree in Biology, Biochemistry, Biophysics, Biotechnology or closely related fields, with a strong record of research productivity.
Strong publication record.
The ability to properly report, organize and publish research data.
Documented experience in coaching junior scientists.
Good command in spoken and written English.
ADDITIONAL SKILLS
Strong problem‑solving attitude.
High motivation to learn.
Spirit of innovation and creativity.
Good in time and priority management.
Ability to work in a challenging and international environment.
Ability to work independently and collaboratively in a highly interdisciplinary environment.
COMPENSATION & BENEFITS
Competitive salary package for international standards. It will reflect experience and expertise and will be determined after the interview.
Wide range of staff discounts.
Flexible working time.
Possibility to have fiscal benefits: two tax reliefs currently available – the fiscal benefit for Researchers and Teachers from abroad (Tremonti) and the one for Impatriate workers (Internationalization Decree).
#J-18808-Ljbffr