Principal Scientist/Director, Translational Pharmacology
5AM Ventures, Emeryville, CA, United States
We areseekinga highly motivated, hands-on Director of Translational Pharmacology to lead and drive preclinical pharmacology efforts across our pipeline. This individual will play a central, decision-making role in translating innovative science intorigorous, invivo proof-of-concept and clinically actionable pharmacology strategies.
Responsibilities
Lead the design, execution, and interpretation of preclinical pharmacology studies supporting drug discovery and development programs
Develop and apply quantitative PK/PD models, integrating pharmacokinetics, pharmacodynamics, and chemical kinetics to guide compound optimization and dosing strategies
Design and oversee in vivo studies, including selection and development of appropriate animal models
Drive rigorous data analysis, including statistical evaluation and modeling to inform decision-making
Translate preclinical findings into clinically relevant hypotheses and development strategies
Collaborate closely with teams to optimize drug candidates and delivery systems
Contribute to regulatory documentation and strategy (IND-enabling studies, study reports, etc.)
Build and manage relationships with CROs and external collaborators
Qualifications
PhD, MD, or equivalent in pharmacology, biomedical sciences, or related field
Significant experience in preclinical pharmacology within biotech or pharmaceutical settings
Experience in choosing appropriate animal models
Deep expertise in PK/PD modeling, with strong grounding in chemical kinetics and quantitative biology
Proven experience designing studies to evaluate drug combinations and synergy, including application of factorial experimental design. Demonstrated experience designing and interpreting in vivo pharmacology studies
Experience in advancing preclinical candidates through IND-enabling studies and contributing meaningfully to IND submissions
Strong statistical and data analysis skills
Experience in metabolic diseases, particularly obesity and/or diabetes, strongly preferred
Compensation $180,000 - $230,000 a year. Final compensation will be based on a candidate’s qualifications, experience, and geographic location. Employees are also eligible for performance bonuses, equity participation and comprehensive health benefits.
Equal Opportunity We believe in building balanced teams. We are an equal opportunity employer. We do not discriminate in regard to race, color, religion, national origin, age, sex, sexual orientation, gender identity, marital status, ancestry, physical or mental disability, veteran status, or any other legally protected characteristics.
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Responsibilities
Lead the design, execution, and interpretation of preclinical pharmacology studies supporting drug discovery and development programs
Develop and apply quantitative PK/PD models, integrating pharmacokinetics, pharmacodynamics, and chemical kinetics to guide compound optimization and dosing strategies
Design and oversee in vivo studies, including selection and development of appropriate animal models
Drive rigorous data analysis, including statistical evaluation and modeling to inform decision-making
Translate preclinical findings into clinically relevant hypotheses and development strategies
Collaborate closely with teams to optimize drug candidates and delivery systems
Contribute to regulatory documentation and strategy (IND-enabling studies, study reports, etc.)
Build and manage relationships with CROs and external collaborators
Qualifications
PhD, MD, or equivalent in pharmacology, biomedical sciences, or related field
Significant experience in preclinical pharmacology within biotech or pharmaceutical settings
Experience in choosing appropriate animal models
Deep expertise in PK/PD modeling, with strong grounding in chemical kinetics and quantitative biology
Proven experience designing studies to evaluate drug combinations and synergy, including application of factorial experimental design. Demonstrated experience designing and interpreting in vivo pharmacology studies
Experience in advancing preclinical candidates through IND-enabling studies and contributing meaningfully to IND submissions
Strong statistical and data analysis skills
Experience in metabolic diseases, particularly obesity and/or diabetes, strongly preferred
Compensation $180,000 - $230,000 a year. Final compensation will be based on a candidate’s qualifications, experience, and geographic location. Employees are also eligible for performance bonuses, equity participation and comprehensive health benefits.
Equal Opportunity We believe in building balanced teams. We are an equal opportunity employer. We do not discriminate in regard to race, color, religion, national origin, age, sex, sexual orientation, gender identity, marital status, ancestry, physical or mental disability, veteran status, or any other legally protected characteristics.
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