Executive Director, Data Management
Xencor, San Diego, CA, United States
Executive Director, Data Management
Introduction: Xencor is a public, clinical‑stage biopharmaceutical company located in the Los Angeles area (Pasadena) and San Diego. Our focus is developing high‑potential XmAb® bispecific T‑cell engagers and additional engineered drug candidates that leverage our differentiated technology platforms. We are advancing our pipeline toward clinical proof‑of‑concept decisions, aiming to create high‑impact therapeutics for patients with cancer and other serious diseases. More than 20 XmAb drug candidates are in clinical development, and three XmAb medicines have been marketed by partners. For more information, visit
www.xencor.com .
This position can be based out of our San Diego or Pasadena, CA sites. It is a hybrid position with a minimum of 2 days per week on‑site.
Position Overview
Responsible for leading the strategy, operations, and evolution of Xencor’s clinical data infrastructure, ensuring high‑quality data that supports rapid, informed development decisions.
Primary Responsibilities
Designs and executes a scalable Clinical Data Management (CDM) strategy that supports an expanding portfolio, including programs approaching Phase 3.
Provides strong leadership for the CDM function, including recruiting, training, mentoring, performance management, and growth of the CDM department.
Provides operational leadership for acquisition, integration, quality control, and delivery of clinical trial data.
Oversees vendor and technology strategy, including evaluation, selection, contracting, and performance oversight for CDM services from study start‑up through database lock and final reporting.
Partners with other Development functions (e.g., Clinical Operations, Clinical Development) to resolve issues and ensure that CRF designs, data transfers, extracts, and other CDM activities support high‑quality analyses and regulatory compliance.
Collaborates closely with Biostatistics and Statistical Programming to ensure clinical data structure supports efficient analysis, interim decision‑making, and regulatory submissions.
Leads implementation of risk‑based data management strategies, including centralized data review, dashboarding, and issue management workflows.
Serves as the functional expert accountable for CDM processes, including development and implementation of enterprise data standards and documentation.
Oversees the development of standards for data management documentation (e.g., Data Management Plans, eCRF completion guidelines, coding guidelines, Data Validation Specifications).
Other duties as assigned.
Education, Experience, and Skills
Position requires a BS degree in a related field and a minimum of 18 years of relevant experience, with at least 12 years in clinical data management within the pharmaceutical or biotechnology industry, and at least 6 years of people and team management. Prior clinical trial responsibility for the full data management lifecycle is also required.
Good working knowledge of ICH, FDA, and GCP regulations and guidelines.
Thorough knowledge of related industry standards including MedDRA, WHODrug, CDASH, SDTM, and other CDISC Foundational Standards.
Understanding of data management technology, software languages, and computer systems.
Sound knowledge of clinical trial processes and data management, clinical operations, biometrics, quality management, and systems applications to support operations.
Competency in multiple computer‑based tools, in addition to software programs such as Word, PowerPoint, Excel, etc.
A proven people leader with experience managing, mentoring, and developing team members to achieve strong performance and organizational goals.
Ability to work in and effectively contribute to cross‑functional teams in face‑to‑face conversation, by telephone, and by email.
Excellent verbal/written and interpersonal skills.
Ability to create strong, collaborative working relationships and encourage creative solutions by navigating conflicts.
Ability to demonstrate competencies applicable for the role based on Xencor’s Leadership Competency Model.
Ability to effectively manage others through coaching and supervision, ensuring employee performance meets the organization’s expectations for conduct, productivity, quality, continuous improvement, and goal accomplishment.
Travel and Work Environment
Occasional travel may be required, including travel between Xencor’s Pasadena and San Diego offices. Work for this position is generally performed at Xencor’s site and requires full‑time commitment.
Compensation and Benefits
Expected Base Salary Range: $263,000 - $315,000. The actual salary will be based on the selected candidate’s qualifications, including skills, competencies, education, and experience.
Xencor offers a competitive total rewards package including 401(k) match, healthcare coverage, ESPP, and a broad range of other benefits. This position is eligible for an annual bonus and equity grant. For more information, please see
our careers page .
Americans with Disabilities Act (ADA) Statement
The Company will provide reasonable accommodations (such as a qualified sign language interpreter or other personal assistance) with the application process upon request, as required by applicable law. Reasonable accommodations may be made to enable qualified individuals with disabilities to perform the essential functions of this role.
Equal Employment Opportunity Statement
The Company is an equal‑opportunity employer. All qualified applicants will receive consideration for employment without regard to age, race, color, religion, sex, sexual orientation, gender identity, national origin, disability status, protected veteran status, or any other characteristic protected by state or federal law. Xencor does not accept profiles or resumes from recruiting vendors without a binding written agreement. Any unsolicited submission of services or resumes does not create an obligation or duty by Xencor.
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Introduction: Xencor is a public, clinical‑stage biopharmaceutical company located in the Los Angeles area (Pasadena) and San Diego. Our focus is developing high‑potential XmAb® bispecific T‑cell engagers and additional engineered drug candidates that leverage our differentiated technology platforms. We are advancing our pipeline toward clinical proof‑of‑concept decisions, aiming to create high‑impact therapeutics for patients with cancer and other serious diseases. More than 20 XmAb drug candidates are in clinical development, and three XmAb medicines have been marketed by partners. For more information, visit
www.xencor.com .
This position can be based out of our San Diego or Pasadena, CA sites. It is a hybrid position with a minimum of 2 days per week on‑site.
Position Overview
Responsible for leading the strategy, operations, and evolution of Xencor’s clinical data infrastructure, ensuring high‑quality data that supports rapid, informed development decisions.
Primary Responsibilities
Designs and executes a scalable Clinical Data Management (CDM) strategy that supports an expanding portfolio, including programs approaching Phase 3.
Provides strong leadership for the CDM function, including recruiting, training, mentoring, performance management, and growth of the CDM department.
Provides operational leadership for acquisition, integration, quality control, and delivery of clinical trial data.
Oversees vendor and technology strategy, including evaluation, selection, contracting, and performance oversight for CDM services from study start‑up through database lock and final reporting.
Partners with other Development functions (e.g., Clinical Operations, Clinical Development) to resolve issues and ensure that CRF designs, data transfers, extracts, and other CDM activities support high‑quality analyses and regulatory compliance.
Collaborates closely with Biostatistics and Statistical Programming to ensure clinical data structure supports efficient analysis, interim decision‑making, and regulatory submissions.
Leads implementation of risk‑based data management strategies, including centralized data review, dashboarding, and issue management workflows.
Serves as the functional expert accountable for CDM processes, including development and implementation of enterprise data standards and documentation.
Oversees the development of standards for data management documentation (e.g., Data Management Plans, eCRF completion guidelines, coding guidelines, Data Validation Specifications).
Other duties as assigned.
Education, Experience, and Skills
Position requires a BS degree in a related field and a minimum of 18 years of relevant experience, with at least 12 years in clinical data management within the pharmaceutical or biotechnology industry, and at least 6 years of people and team management. Prior clinical trial responsibility for the full data management lifecycle is also required.
Good working knowledge of ICH, FDA, and GCP regulations and guidelines.
Thorough knowledge of related industry standards including MedDRA, WHODrug, CDASH, SDTM, and other CDISC Foundational Standards.
Understanding of data management technology, software languages, and computer systems.
Sound knowledge of clinical trial processes and data management, clinical operations, biometrics, quality management, and systems applications to support operations.
Competency in multiple computer‑based tools, in addition to software programs such as Word, PowerPoint, Excel, etc.
A proven people leader with experience managing, mentoring, and developing team members to achieve strong performance and organizational goals.
Ability to work in and effectively contribute to cross‑functional teams in face‑to‑face conversation, by telephone, and by email.
Excellent verbal/written and interpersonal skills.
Ability to create strong, collaborative working relationships and encourage creative solutions by navigating conflicts.
Ability to demonstrate competencies applicable for the role based on Xencor’s Leadership Competency Model.
Ability to effectively manage others through coaching and supervision, ensuring employee performance meets the organization’s expectations for conduct, productivity, quality, continuous improvement, and goal accomplishment.
Travel and Work Environment
Occasional travel may be required, including travel between Xencor’s Pasadena and San Diego offices. Work for this position is generally performed at Xencor’s site and requires full‑time commitment.
Compensation and Benefits
Expected Base Salary Range: $263,000 - $315,000. The actual salary will be based on the selected candidate’s qualifications, including skills, competencies, education, and experience.
Xencor offers a competitive total rewards package including 401(k) match, healthcare coverage, ESPP, and a broad range of other benefits. This position is eligible for an annual bonus and equity grant. For more information, please see
our careers page .
Americans with Disabilities Act (ADA) Statement
The Company will provide reasonable accommodations (such as a qualified sign language interpreter or other personal assistance) with the application process upon request, as required by applicable law. Reasonable accommodations may be made to enable qualified individuals with disabilities to perform the essential functions of this role.
Equal Employment Opportunity Statement
The Company is an equal‑opportunity employer. All qualified applicants will receive consideration for employment without regard to age, race, color, religion, sex, sexual orientation, gender identity, national origin, disability status, protected veteran status, or any other characteristic protected by state or federal law. Xencor does not accept profiles or resumes from recruiting vendors without a binding written agreement. Any unsolicited submission of services or resumes does not create an obligation or duty by Xencor.
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