Protein Purification Scientist
Sino Biological, Inc., Houston, TX, United States
About the Role
We are seeking a highly skilled Protein Purification Scientist to support downstream process development and purification of recombinant proteins and antibodies. This role will be responsible for executing purification workflows, performing analytical characterization, and ensuring high-quality deliverables in a fast-paced, client-driven environment.
Responsibilities
Downstream Processing & Chromatography
Operate and maintain AKTA Pure systems using UNICORN software for protein and antibody purification
Execute purification processes for proteins expressed in mammalian systems (HEK293, CHO)
Apply chromatography techniques including:
Affinity (IMAC, Protein A/G)
Ion Exchange (IEX)
Size Exclusion (SEC)
Hydrophobic Interaction (HIC)
Scale purification workflows from pilot to multi-liter production
Perform column packing, optimization, and troubleshooting
Quality Control & Analytical Characterization
Conduct protein analysis using SDS-PAGE and Western Blot
Perform HPLC-SEC for protein purity and aggregation assessment
Execute stability and binding assays including:
Differential Scanning Fluorimetry (DSF)
ELISA
BLI
Analyze and interpret data to support product quality and development
Documentation & Compliance
Maintain accurate laboratory notebooks and experimental records
Follow SOPs and ensure compliance with internal quality standards
Support documentation required for traceability in a CRO/client-facing environment
Requirements
Ph.D., Master’s, or Bachelor’s degree in Biochemistry, Molecular Biology, Biotechnology, or related field.
Hands-on experience with protein purification and downstream processing
Strong expertise in chromatography and analytical techniques listed above
Experience working with mammalian expression systems preferred
Prior experience in a CRO or fast-paced research environment is a plus
Strong problem-solving and troubleshooting skills
Ability to manage multiple projects and timelines
Detail-oriented with a focus on quality and accuracy
Effective communication and collaboration skills
Why Join Us at C4B?
Working at Sino Biological’s C4B facility isn’t just another lab job, it’s a chance to be part of something bigger. Here are just a few of the unique benefits of our Houston site:
Opportunity to work on cutting-edge protein and antibody development
Collaborative, high-impact scientific environment
Growth opportunities within both technical and client-facing career paths
World-class location: Be part of the Texas Medical Center, the largest medical complex in the world, where biotech innovation thrives.
Beautiful work environment: Enjoy a brand-new, state-of-the-art facility designed for collaboration and scientific excellence.
Free onsite parking: Skip the hassle and expense of parking in the Medical Center, we’ve got you covered.
Free onsite gym: Stay active and energized with convenient access to fitness facilities right at work.
Career growth opportunities: Learn directly from industry professionals while growing your career at a global biotech company.
Supportive team culture: A welcoming, team-first workplace that values diversity, collaboration, and professional development.
Join Us in Advancing Scientific Innovation
Be a part of Sino Biological and contribute to groundbreaking scientific advancements worldwide. Apply today to join our dynamic team!
Sino Biological is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.
#J-18808-Ljbffr
We are seeking a highly skilled Protein Purification Scientist to support downstream process development and purification of recombinant proteins and antibodies. This role will be responsible for executing purification workflows, performing analytical characterization, and ensuring high-quality deliverables in a fast-paced, client-driven environment.
Responsibilities
Downstream Processing & Chromatography
Operate and maintain AKTA Pure systems using UNICORN software for protein and antibody purification
Execute purification processes for proteins expressed in mammalian systems (HEK293, CHO)
Apply chromatography techniques including:
Affinity (IMAC, Protein A/G)
Ion Exchange (IEX)
Size Exclusion (SEC)
Hydrophobic Interaction (HIC)
Scale purification workflows from pilot to multi-liter production
Perform column packing, optimization, and troubleshooting
Quality Control & Analytical Characterization
Conduct protein analysis using SDS-PAGE and Western Blot
Perform HPLC-SEC for protein purity and aggregation assessment
Execute stability and binding assays including:
Differential Scanning Fluorimetry (DSF)
ELISA
BLI
Analyze and interpret data to support product quality and development
Documentation & Compliance
Maintain accurate laboratory notebooks and experimental records
Follow SOPs and ensure compliance with internal quality standards
Support documentation required for traceability in a CRO/client-facing environment
Requirements
Ph.D., Master’s, or Bachelor’s degree in Biochemistry, Molecular Biology, Biotechnology, or related field.
Hands-on experience with protein purification and downstream processing
Strong expertise in chromatography and analytical techniques listed above
Experience working with mammalian expression systems preferred
Prior experience in a CRO or fast-paced research environment is a plus
Strong problem-solving and troubleshooting skills
Ability to manage multiple projects and timelines
Detail-oriented with a focus on quality and accuracy
Effective communication and collaboration skills
Why Join Us at C4B?
Working at Sino Biological’s C4B facility isn’t just another lab job, it’s a chance to be part of something bigger. Here are just a few of the unique benefits of our Houston site:
Opportunity to work on cutting-edge protein and antibody development
Collaborative, high-impact scientific environment
Growth opportunities within both technical and client-facing career paths
World-class location: Be part of the Texas Medical Center, the largest medical complex in the world, where biotech innovation thrives.
Beautiful work environment: Enjoy a brand-new, state-of-the-art facility designed for collaboration and scientific excellence.
Free onsite parking: Skip the hassle and expense of parking in the Medical Center, we’ve got you covered.
Free onsite gym: Stay active and energized with convenient access to fitness facilities right at work.
Career growth opportunities: Learn directly from industry professionals while growing your career at a global biotech company.
Supportive team culture: A welcoming, team-first workplace that values diversity, collaboration, and professional development.
Join Us in Advancing Scientific Innovation
Be a part of Sino Biological and contribute to groundbreaking scientific advancements worldwide. Apply today to join our dynamic team!
Sino Biological is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.
#J-18808-Ljbffr