Post Doctoral Scholar- Microbial Infection and Immunity
The Ohio State University Wexner Medical Center, Columbus, OH, United States
Overview
The research project is centered on the metabolic reprogramming that regulates tumor-infiltrating myeloid cells and their interplay with T cells in mouse models and in humans. The Post Doctoral Researcher will pursue specialized research training under the guidance of a scientific mentor; conduct research to characterize the immunologic and genetic basis of human cancers; develop, adopt and implement new experimental methods to characterize various human immune cell types and their developmental pathways; delineate mechanisms of tumor resistance to immunotherapy, such as immune checkpoint inhibitors (ICI); identify novel genes and examine their role in immunologic approaches to disease treatment; analyze changes in mRNA or protein expression, flow cytometric data, gene cloning and mutation detection; integrate cutting-edge single-cell RNA sequencing and multi-parameter flow cytometry with traditional molecular biology approaches; participate in data analysis for reports for grant submissions; design and conduct pre-clinical studies using mouse disease models; train staff and contribute to understanding resistance to ICI, identify new targets for therapeutics, and explore biomarkers for novel treatments/combinations.
Experience with high-dimensional data analysis (e.g., single-cell RNA-Seq) is highly desirable. Prior experience working with research animals (mice), DNA/RNA/Protein isolation and purification, PCR/qPCR, Western and Northern blot techniques, and training others in molecular biology techniques such as cloning and real-time PCR is preferred.
Responsibilities
Design and conduct research to characterize immunologic and genetic aspects of human cancers.
Develop and implement new experimental methods to characterize immune cell types and developmental pathways.
Delineate mechanisms of tumor resistance to immunotherapy and identify novel gene roles in immunologic therapies.
Analyze changes in mRNA/protein expression and perform flow cytometry, gene cloning and mutation detection.
Integrate single-cell RNA sequencing and multi-parameter flow cytometry with traditional molecular biology approaches.
Participate in data analysis for grant submissions and prepare reports.
Design and conduct pre-clinical studies using mouse disease models.
Train staff and contribute to the understanding of resistance to ICI and development of novel therapeutics and biomarkers.
Use multi-color flow cytometry, cell isolation, and primary cell/tissue culture techniques.
Qualifications
Doctoral degree in an appropriate discipline required.
Experience with mice, DNA/RNA/Protein isolation and purification, PCR/qPCR, Western blot techniques, molecular cloning, mammalian cell culture, and flow cytometric data collection and analysis preferred.
Application Instructions
Applicants should submit their current curriculum vitae with a publication list and the name and email contact information of three references with their application in Workday.
The Ohio State University Wexner Medical Center in Columbus, Ohio is the only academic medical center in Central Ohio and ranked among “America’s Best Hospitals” by U.S. News and World Report for 20 consecutive years. We are committed to comprehensive patient care, high-caliber research and innovative medical education for medical students, post-doctoral trainees and professional colleagues.
The OSUCCC – James is the only cancer program in the United States that features an NCI-designated comprehensive cancer center aligned with a nationally ranked academic medical center and a freestanding cancer hospital on the campus of one of the nation’s largest public universities.
The Ohio State University offers a competitive salary, outstanding benefits, participation in workshops and conferences, high-quality Shared Resources, and many opportunities for continued professional development.
The Ohio State University is situated in Columbus, Ohio, a vibrant international city. Columbus offers diverse culture, sports, and activities and an affordable standard of living.
The Ohio State University is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation or identity, national origin, disability status, or protected veteran status.
Screen reader users may encounter difficulty with the online application. For assistance with applying, please contact hr-accessibleapplication@osu.edu. If you have questions while submitting an application, please review these frequently asked questions.
Final candidates are subject to successful completion of a background check. A drug screen or physical may be required during the post-offer process.
The university is an equal opportunity employer, including veterans and disability.
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The research project is centered on the metabolic reprogramming that regulates tumor-infiltrating myeloid cells and their interplay with T cells in mouse models and in humans. The Post Doctoral Researcher will pursue specialized research training under the guidance of a scientific mentor; conduct research to characterize the immunologic and genetic basis of human cancers; develop, adopt and implement new experimental methods to characterize various human immune cell types and their developmental pathways; delineate mechanisms of tumor resistance to immunotherapy, such as immune checkpoint inhibitors (ICI); identify novel genes and examine their role in immunologic approaches to disease treatment; analyze changes in mRNA or protein expression, flow cytometric data, gene cloning and mutation detection; integrate cutting-edge single-cell RNA sequencing and multi-parameter flow cytometry with traditional molecular biology approaches; participate in data analysis for reports for grant submissions; design and conduct pre-clinical studies using mouse disease models; train staff and contribute to understanding resistance to ICI, identify new targets for therapeutics, and explore biomarkers for novel treatments/combinations.
Experience with high-dimensional data analysis (e.g., single-cell RNA-Seq) is highly desirable. Prior experience working with research animals (mice), DNA/RNA/Protein isolation and purification, PCR/qPCR, Western and Northern blot techniques, and training others in molecular biology techniques such as cloning and real-time PCR is preferred.
Responsibilities
Design and conduct research to characterize immunologic and genetic aspects of human cancers.
Develop and implement new experimental methods to characterize immune cell types and developmental pathways.
Delineate mechanisms of tumor resistance to immunotherapy and identify novel gene roles in immunologic therapies.
Analyze changes in mRNA/protein expression and perform flow cytometry, gene cloning and mutation detection.
Integrate single-cell RNA sequencing and multi-parameter flow cytometry with traditional molecular biology approaches.
Participate in data analysis for grant submissions and prepare reports.
Design and conduct pre-clinical studies using mouse disease models.
Train staff and contribute to the understanding of resistance to ICI and development of novel therapeutics and biomarkers.
Use multi-color flow cytometry, cell isolation, and primary cell/tissue culture techniques.
Qualifications
Doctoral degree in an appropriate discipline required.
Experience with mice, DNA/RNA/Protein isolation and purification, PCR/qPCR, Western blot techniques, molecular cloning, mammalian cell culture, and flow cytometric data collection and analysis preferred.
Application Instructions
Applicants should submit their current curriculum vitae with a publication list and the name and email contact information of three references with their application in Workday.
The Ohio State University Wexner Medical Center in Columbus, Ohio is the only academic medical center in Central Ohio and ranked among “America’s Best Hospitals” by U.S. News and World Report for 20 consecutive years. We are committed to comprehensive patient care, high-caliber research and innovative medical education for medical students, post-doctoral trainees and professional colleagues.
The OSUCCC – James is the only cancer program in the United States that features an NCI-designated comprehensive cancer center aligned with a nationally ranked academic medical center and a freestanding cancer hospital on the campus of one of the nation’s largest public universities.
The Ohio State University offers a competitive salary, outstanding benefits, participation in workshops and conferences, high-quality Shared Resources, and many opportunities for continued professional development.
The Ohio State University is situated in Columbus, Ohio, a vibrant international city. Columbus offers diverse culture, sports, and activities and an affordable standard of living.
The Ohio State University is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation or identity, national origin, disability status, or protected veteran status.
Screen reader users may encounter difficulty with the online application. For assistance with applying, please contact hr-accessibleapplication@osu.edu. If you have questions while submitting an application, please review these frequently asked questions.
Final candidates are subject to successful completion of a background check. A drug screen or physical may be required during the post-offer process.
The university is an equal opportunity employer, including veterans and disability.
#J-18808-Ljbffr