Senior Research Associate, Tissue Culture
Skills Alliance Enterprise, San Francisco, CA, United States
As a Senior Research Associate at this Stealth‑mode startup, you will work on the Product Engineering team interfacing with Molecular Biology and Computational Biology groups. In this role, you will help translate AI predictions into experimental validation by executing the bench work needed for rapid iteration of gene editing designs.
Responsibilities
Conduct high‑throughput cell culture experiments, performing plasmid transfections to validate AI‑predicted gene editing designs in human cell models.
Work closely with computational scientists and molecular biologists to rapidly design, build and test novel gene editing systems in human cells.
Assist in the production of research‑scale AAV preparations for delivering gene editing systems to target cells.
Perform routine molecular biology techniques including plasmid miniprep, Gibson assembly, and other cloning methods.
Provide general lab support and maintenance.
Foster collaboration with cross‑functional teams to accelerate therapeutic development through iterative design‑build‑test cycles.
Requirements
A bachelor’s or master’s in Biology, Molecular Biology, Genetics or related life science discipline.
A minimum of two years of experience in industry or academic research.
Hands‑on experience with mammalian cell culture, including transfection techniques in human cell lines.
Proficiency in standard molecular biology techniques such as plasmid miniprep, Gibson assembly, restriction digest, and PCR.
Preferred Qualifications
Familiarity with high‑throughput experimental workflows and data‑driven design testing cycles.
Strong organizational skills and attention to detail in maintaining lab equipment, reagents, and documentation.
Demonstrated ability to collaborate effectively across interdisciplinary teams, including computational and wet lab scientists.
Adaptability in a fast‑paced research environment and enthusiasm for iterative, hypothesis‑driven experimentation.
Previous experience using CRISPR‑Cas or similar gene editing tools for therapeutic applications.
Previous experience using AAV as a therapeutic vector.
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Responsibilities
Conduct high‑throughput cell culture experiments, performing plasmid transfections to validate AI‑predicted gene editing designs in human cell models.
Work closely with computational scientists and molecular biologists to rapidly design, build and test novel gene editing systems in human cells.
Assist in the production of research‑scale AAV preparations for delivering gene editing systems to target cells.
Perform routine molecular biology techniques including plasmid miniprep, Gibson assembly, and other cloning methods.
Provide general lab support and maintenance.
Foster collaboration with cross‑functional teams to accelerate therapeutic development through iterative design‑build‑test cycles.
Requirements
A bachelor’s or master’s in Biology, Molecular Biology, Genetics or related life science discipline.
A minimum of two years of experience in industry or academic research.
Hands‑on experience with mammalian cell culture, including transfection techniques in human cell lines.
Proficiency in standard molecular biology techniques such as plasmid miniprep, Gibson assembly, restriction digest, and PCR.
Preferred Qualifications
Familiarity with high‑throughput experimental workflows and data‑driven design testing cycles.
Strong organizational skills and attention to detail in maintaining lab equipment, reagents, and documentation.
Demonstrated ability to collaborate effectively across interdisciplinary teams, including computational and wet lab scientists.
Adaptability in a fast‑paced research environment and enthusiasm for iterative, hypothesis‑driven experimentation.
Previous experience using CRISPR‑Cas or similar gene editing tools for therapeutic applications.
Previous experience using AAV as a therapeutic vector.
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